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Gene: RASSF8 |
Gene summary for RASSF8 |
Gene summary. |
Gene information | Species | Human | Gene symbol | RASSF8 | Gene ID | 11228 |
Gene name | Ras association domain family member 8 | |
Gene Alias | C12orf2 | |
Cytomap | 12p12.1 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | A0A024RB12 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11228 | RASSF8 | HCC1_Meng | Human | Liver | HCC | 2.46e-16 | -1.35e-01 | 0.0246 |
11228 | RASSF8 | HCC2_Meng | Human | Liver | HCC | 4.91e-02 | -1.20e-01 | 0.0107 |
11228 | RASSF8 | HCC1 | Human | Liver | HCC | 1.69e-03 | 2.21e+00 | 0.5336 |
11228 | RASSF8 | HCC2 | Human | Liver | HCC | 1.04e-03 | 9.71e-01 | 0.5341 |
11228 | RASSF8 | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 3.00e-05 | 8.85e-01 | -0.1408 |
11228 | RASSF8 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 2.53e-03 | 7.65e-01 | -0.138 |
11228 | RASSF8 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 2.50e-09 | 5.70e-01 | -0.2116 |
11228 | RASSF8 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 2.02e-02 | 5.22e-01 | -0.1941 |
11228 | RASSF8 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 9.47e-08 | 7.03e-01 | -0.2107 |
11228 | RASSF8 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 9.22e-13 | 7.15e-01 | -0.2119 |
11228 | RASSF8 | RNA-P6T1-P6T1-2 | Human | Lung | MIAC | 4.36e-02 | 8.04e-01 | -0.0186 |
11228 | RASSF8 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 2.65e-09 | 4.03e-01 | -0.0166 |
11228 | RASSF8 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.01e-10 | 3.65e-01 | -0.0132 |
11228 | RASSF8 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 2.01e-08 | 2.94e-01 | -0.013 |
11228 | RASSF8 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 5.94e-08 | 3.66e-01 | -0.0121 |
11228 | RASSF8 | RNA-P8T2-P8T2-3 | Human | Lung | AIS | 1.70e-02 | 6.75e-01 | -0.1284 |
11228 | RASSF8 | GSM5252132_BPH389PrGF | Human | Prostate | BPH | 1.14e-15 | 9.98e-01 | -0.2247 |
11228 | RASSF8 | 047563_1562-all-cells | Human | Prostate | BPH | 5.25e-11 | 4.37e-01 | 0.0791 |
11228 | RASSF8 | 048752_1579-all-cells | Human | Prostate | BPH | 6.82e-27 | 7.40e-01 | 0.1008 |
11228 | RASSF8 | 052095_1628-all-cells | Human | Prostate | BPH | 5.46e-05 | 3.59e-01 | 0.1032 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RASSF8 | SNV | Missense_Mutation | novel | c.107N>C | p.Arg36Pro | p.R36P | Q8NHQ8 | protein_coding | deleterious(0.01) | probably_damaging(0.965) | TCGA-44-2668-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
RASSF8 | SNV | Missense_Mutation | rs746967473 | c.985N>T | p.Arg329Cys | p.R329C | Q8NHQ8 | protein_coding | deleterious(0.01) | possibly_damaging(0.818) | TCGA-78-7159-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RASSF8 | SNV | Missense_Mutation | c.868G>C | p.Glu290Gln | p.E290Q | Q8NHQ8 | protein_coding | tolerated(0.07) | benign(0.005) | TCGA-95-7944-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RASSF8 | SNV | Missense_Mutation | novel | c.19N>T | p.Val7Leu | p.V7L | Q8NHQ8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-37-4132-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RASSF8 | SNV | Missense_Mutation | novel | c.661N>A | p.Glu221Lys | p.E221K | Q8NHQ8 | protein_coding | tolerated(0.67) | benign(0.038) | TCGA-56-A5DR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RASSF8 | SNV | Missense_Mutation | c.403N>A | p.Gly135Ser | p.G135S | Q8NHQ8 | protein_coding | deleterious(0.02) | probably_damaging(0.92) | TCGA-63-5128-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unknown | Unknown | PD | |
RASSF8 | SNV | Missense_Mutation | c.404N>C | p.Gly135Ala | p.G135A | Q8NHQ8 | protein_coding | tolerated(0.14) | possibly_damaging(0.834) | TCGA-63-5128-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unknown | Unknown | PD | |
RASSF8 | SNV | Missense_Mutation | rs756607785 | c.1033N>T | p.Arg345Trp | p.R345W | Q8NHQ8 | protein_coding | deleterious(0) | probably_damaging(0.948) | TCGA-66-2792-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR |
RASSF8 | SNV | Missense_Mutation | rs146204306 | c.511N>T | p.Arg171Cys | p.R171C | Q8NHQ8 | protein_coding | deleterious(0.02) | benign(0.084) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RASSF8 | SNV | Missense_Mutation | c.319N>T | p.Pro107Ser | p.P107S | Q8NHQ8 | protein_coding | deleterious(0) | benign(0.063) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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