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Gene: RARRES1 |
Gene summary for RARRES1 |
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Gene information | Species | Human | Gene symbol | RARRES1 | Gene ID | 5918 |
Gene name | retinoic acid receptor responder 1 | |
Gene Alias | LXNL | |
Cytomap | 3q25.32 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | P49788 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5918 | RARRES1 | GSM4909281 | Human | Breast | IDC | 7.62e-08 | -5.93e-01 | 0.21 |
5918 | RARRES1 | GSM4909282 | Human | Breast | IDC | 9.83e-25 | 3.46e-01 | -0.0288 |
5918 | RARRES1 | GSM4909285 | Human | Breast | IDC | 2.28e-15 | 5.47e-02 | 0.21 |
5918 | RARRES1 | GSM4909286 | Human | Breast | IDC | 1.87e-24 | -7.69e-01 | 0.1081 |
5918 | RARRES1 | GSM4909290 | Human | Breast | IDC | 1.16e-04 | -5.88e-01 | 0.2096 |
5918 | RARRES1 | GSM4909291 | Human | Breast | IDC | 3.79e-10 | -7.55e-01 | 0.1753 |
5918 | RARRES1 | GSM4909293 | Human | Breast | IDC | 1.83e-08 | -6.02e-01 | 0.1581 |
5918 | RARRES1 | GSM4909294 | Human | Breast | IDC | 2.45e-14 | -6.93e-01 | 0.2022 |
5918 | RARRES1 | GSM4909295 | Human | Breast | IDC | 1.85e-02 | 4.85e-02 | 0.0898 |
5918 | RARRES1 | GSM4909296 | Human | Breast | IDC | 5.04e-20 | -7.61e-01 | 0.1524 |
5918 | RARRES1 | GSM4909297 | Human | Breast | IDC | 1.29e-07 | -6.06e-01 | 0.1517 |
5918 | RARRES1 | GSM4909298 | Human | Breast | IDC | 2.16e-09 | -6.48e-01 | 0.1551 |
5918 | RARRES1 | GSM4909299 | Human | Breast | IDC | 6.37e-21 | 5.78e-01 | 0.035 |
5918 | RARRES1 | GSM4909300 | Human | Breast | IDC | 1.60e-04 | 2.89e-01 | 0.0334 |
5918 | RARRES1 | GSM4909301 | Human | Breast | IDC | 1.11e-22 | -7.73e-01 | 0.1577 |
5918 | RARRES1 | GSM4909302 | Human | Breast | IDC | 1.19e-17 | -7.48e-01 | 0.1545 |
5918 | RARRES1 | GSM4909303 | Human | Breast | IDC | 1.94e-03 | -7.40e-01 | 0.0438 |
5918 | RARRES1 | GSM4909304 | Human | Breast | IDC | 3.27e-25 | -7.73e-01 | 0.1636 |
5918 | RARRES1 | GSM4909305 | Human | Breast | IDC | 4.59e-05 | -2.65e-02 | 0.0436 |
5918 | RARRES1 | GSM4909306 | Human | Breast | IDC | 1.48e-04 | -5.33e-01 | 0.1564 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00525479 | Breast | Precancer | regulation of peptidase activity | 71/1080 | 461/18723 | 2.72e-14 | 6.94e-12 | 71 |
GO:00525489 | Breast | Precancer | regulation of endopeptidase activity | 67/1080 | 432/18723 | 1.06e-13 | 2.36e-11 | 67 |
GO:00458619 | Breast | Precancer | negative regulation of proteolysis | 50/1080 | 351/18723 | 2.99e-09 | 2.39e-07 | 50 |
GO:00513468 | Breast | Precancer | negative regulation of hydrolase activity | 50/1080 | 379/18723 | 3.85e-08 | 2.34e-06 | 50 |
GO:00104668 | Breast | Precancer | negative regulation of peptidase activity | 38/1080 | 262/18723 | 1.46e-07 | 7.82e-06 | 38 |
GO:00109519 | Breast | Precancer | negative regulation of endopeptidase activity | 37/1080 | 252/18723 | 1.55e-07 | 8.05e-06 | 37 |
GO:005254714 | Breast | IDC | regulation of peptidase activity | 96/1434 | 461/18723 | 7.58e-20 | 6.15e-17 | 96 |
GO:005254814 | Breast | IDC | regulation of endopeptidase activity | 88/1434 | 432/18723 | 1.20e-17 | 4.85e-15 | 88 |
GO:004586114 | Breast | IDC | negative regulation of proteolysis | 70/1434 | 351/18723 | 8.21e-14 | 2.22e-11 | 70 |
GO:005134613 | Breast | IDC | negative regulation of hydrolase activity | 71/1434 | 379/18723 | 1.33e-12 | 2.90e-10 | 71 |
GO:001046613 | Breast | IDC | negative regulation of peptidase activity | 56/1434 | 262/18723 | 1.39e-12 | 2.92e-10 | 56 |
GO:001095112 | Breast | IDC | negative regulation of endopeptidase activity | 52/1434 | 252/18723 | 3.53e-11 | 5.57e-09 | 52 |
GO:005254723 | Breast | DCIS | regulation of peptidase activity | 88/1390 | 461/18723 | 1.18e-16 | 4.78e-14 | 88 |
GO:005254823 | Breast | DCIS | regulation of endopeptidase activity | 83/1390 | 432/18723 | 6.07e-16 | 2.15e-13 | 83 |
GO:004586123 | Breast | DCIS | negative regulation of proteolysis | 63/1390 | 351/18723 | 4.39e-11 | 6.06e-09 | 63 |
GO:005134623 | Breast | DCIS | negative regulation of hydrolase activity | 64/1390 | 379/18723 | 4.32e-10 | 4.80e-08 | 64 |
GO:001046622 | Breast | DCIS | negative regulation of peptidase activity | 49/1390 | 262/18723 | 1.54e-09 | 1.43e-07 | 49 |
GO:001095122 | Breast | DCIS | negative regulation of endopeptidase activity | 47/1390 | 252/18723 | 3.63e-09 | 3.11e-07 | 47 |
GO:005254710 | Cervix | CC | regulation of peptidase activity | 112/2311 | 461/18723 | 6.70e-13 | 3.08e-10 | 112 |
GO:005254810 | Cervix | CC | regulation of endopeptidase activity | 103/2311 | 432/18723 | 1.89e-11 | 5.14e-09 | 103 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RARRES1 | SNV | Missense_Mutation | novel | c.580N>G | p.Leu194Val | p.L194V | P49788 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
RARRES1 | SNV | Missense_Mutation | rs544435542 | c.307N>A | p.Val103Met | p.V103M | P49788 | protein_coding | deleterious(0) | possibly_damaging(0.875) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RARRES1 | SNV | Missense_Mutation | rs759534219 | c.752G>A | p.Arg251His | p.R251H | P49788 | protein_coding | tolerated(0.99) | benign(0.02) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
RARRES1 | SNV | Missense_Mutation | novel | c.280A>G | p.Asn94Asp | p.N94D | P49788 | protein_coding | tolerated(0.49) | benign(0.028) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
RARRES1 | SNV | Missense_Mutation | novel | c.741N>G | p.Ile247Met | p.I247M | P49788 | protein_coding | tolerated(0.31) | benign(0.378) | TCGA-SJ-A6ZI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RARRES1 | SNV | Missense_Mutation | rs759534219 | c.752N>A | p.Arg251His | p.R251H | P49788 | protein_coding | tolerated(0.99) | benign(0.02) | TCGA-DD-AAEA-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RARRES1 | SNV | Missense_Mutation | novel | c.386G>C | p.Arg129Pro | p.R129P | P49788 | protein_coding | tolerated(0.08) | possibly_damaging(0.642) | TCGA-KK-A8IC-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Hormone Therapy | leuprolide | SD |
RARRES1 | SNV | Missense_Mutation | rs777701079 | c.448N>A | p.Glu150Lys | p.E150K | P49788 | protein_coding | tolerated(0.12) | benign(0.075) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RARRES1 | SNV | Missense_Mutation | c.772N>T | p.Pro258Ser | p.P258S | P49788 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-FP-A4BE-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5918 | RARRES1 | NA | TRETINOIN | TRETINOIN |
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