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Gene: PTGFRN |
Gene summary for PTGFRN |
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Gene information | Species | Human | Gene symbol | PTGFRN | Gene ID | 5738 |
Gene name | prostaglandin F2 receptor inhibitor | |
Gene Alias | CD315 | |
Cytomap | 1p13.1 | |
Gene Type | protein-coding | GO ID | GO:0000768 | UniProtAcc | Q9P2B2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5738 | PTGFRN | CCI_1 | Human | Cervix | CC | 3.64e-04 | 5.99e-01 | 0.528 |
5738 | PTGFRN | CCI_3 | Human | Cervix | CC | 5.21e-06 | 5.79e-01 | 0.516 |
5738 | PTGFRN | Tumor | Human | Cervix | CC | 1.20e-08 | 3.21e-01 | 0.1241 |
5738 | PTGFRN | sample3 | Human | Cervix | CC | 1.45e-06 | 2.83e-01 | 0.1387 |
5738 | PTGFRN | T3 | Human | Cervix | CC | 1.17e-09 | 2.71e-01 | 0.1389 |
5738 | PTGFRN | LZE4T | Human | Esophagus | ESCC | 1.15e-13 | 1.63e-01 | 0.0811 |
5738 | PTGFRN | LZE7T | Human | Esophagus | ESCC | 3.50e-05 | 1.18e-01 | 0.0667 |
5738 | PTGFRN | LZE8T | Human | Esophagus | ESCC | 5.85e-04 | -4.42e-02 | 0.067 |
5738 | PTGFRN | LZE22T | Human | Esophagus | ESCC | 5.38e-04 | 1.63e-01 | 0.068 |
5738 | PTGFRN | LZE24T | Human | Esophagus | ESCC | 5.47e-12 | 6.57e-02 | 0.0596 |
5738 | PTGFRN | LZE21T | Human | Esophagus | ESCC | 2.48e-03 | 5.38e-02 | 0.0655 |
5738 | PTGFRN | P2T-E | Human | Esophagus | ESCC | 2.33e-21 | 2.79e-01 | 0.1177 |
5738 | PTGFRN | P4T-E | Human | Esophagus | ESCC | 5.66e-09 | 2.37e-01 | 0.1323 |
5738 | PTGFRN | P5T-E | Human | Esophagus | ESCC | 6.00e-23 | 2.77e-01 | 0.1327 |
5738 | PTGFRN | P8T-E | Human | Esophagus | ESCC | 6.33e-22 | 1.67e-01 | 0.0889 |
5738 | PTGFRN | P9T-E | Human | Esophagus | ESCC | 2.95e-15 | 1.79e-01 | 0.1131 |
5738 | PTGFRN | P10T-E | Human | Esophagus | ESCC | 3.23e-28 | 6.11e-01 | 0.116 |
5738 | PTGFRN | P11T-E | Human | Esophagus | ESCC | 4.79e-04 | 2.41e-01 | 0.1426 |
5738 | PTGFRN | P12T-E | Human | Esophagus | ESCC | 2.10e-21 | 5.62e-01 | 0.1122 |
5738 | PTGFRN | P15T-E | Human | Esophagus | ESCC | 1.74e-16 | 2.72e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00310996 | Cervix | CC | regeneration | 46/2311 | 198/18723 | 1.43e-05 | 2.84e-04 | 46 |
GO:00426924 | Cervix | CC | muscle cell differentiation | 69/2311 | 384/18723 | 8.12e-04 | 7.09e-03 | 69 |
GO:0042246 | Cervix | CC | tissue regeneration | 19/2311 | 72/18723 | 9.11e-04 | 7.81e-03 | 19 |
GO:00434032 | Cervix | CC | skeletal muscle tissue regeneration | 12/2311 | 37/18723 | 1.15e-03 | 9.39e-03 | 12 |
GO:0000768 | Cervix | CC | syncytium formation by plasma membrane fusion | 15/2311 | 55/18723 | 2.14e-03 | 1.54e-02 | 15 |
GO:0140253 | Cervix | CC | cell-cell fusion | 15/2311 | 55/18723 | 2.14e-03 | 1.54e-02 | 15 |
GO:00069491 | Cervix | CC | syncytium formation | 15/2311 | 57/18723 | 3.13e-03 | 2.05e-02 | 15 |
GO:00511464 | Cervix | CC | striated muscle cell differentiation | 50/2311 | 283/18723 | 5.53e-03 | 3.19e-02 | 50 |
GO:003109910 | Esophagus | ESCC | regeneration | 122/8552 | 198/18723 | 4.26e-06 | 4.57e-05 | 122 |
GO:003109911 | Liver | Cirrhotic | regeneration | 71/4634 | 198/18723 | 3.02e-04 | 2.65e-03 | 71 |
GO:00310992 | Liver | HCC | regeneration | 107/7958 | 198/18723 | 6.67e-04 | 4.12e-03 | 107 |
GO:00310999 | Oral cavity | OSCC | regeneration | 114/7305 | 198/18723 | 8.54e-08 | 1.50e-06 | 114 |
GO:00422464 | Oral cavity | OSCC | tissue regeneration | 42/7305 | 72/18723 | 6.89e-04 | 3.84e-03 | 42 |
GO:00434034 | Oral cavity | OSCC | skeletal muscle tissue regeneration | 23/7305 | 37/18723 | 3.66e-03 | 1.51e-02 | 23 |
GO:00426927 | Oral cavity | OSCC | muscle cell differentiation | 175/7305 | 384/18723 | 4.79e-03 | 1.92e-02 | 175 |
GO:003109916 | Oral cavity | LP | regeneration | 76/4623 | 198/18723 | 1.25e-05 | 2.24e-04 | 76 |
GO:00422461 | Oral cavity | LP | tissue regeneration | 30/4623 | 72/18723 | 1.13e-03 | 9.27e-03 | 30 |
GO:004340311 | Oral cavity | LP | skeletal muscle tissue regeneration | 18/4623 | 37/18723 | 1.36e-03 | 1.08e-02 | 18 |
GO:003109915 | Prostate | Tumor | regeneration | 54/3246 | 198/18723 | 3.07e-04 | 2.47e-03 | 54 |
GO:004269213 | Prostate | Tumor | muscle cell differentiation | 93/3246 | 384/18723 | 3.45e-04 | 2.73e-03 | 93 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTGFRN | SNV | Missense_Mutation | c.445C>T | p.Pro149Ser | p.P149S | Q9P2B2 | protein_coding | tolerated(0.49) | benign(0.011) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PTGFRN | SNV | Missense_Mutation | c.1661C>T | p.Ala554Val | p.A554V | Q9P2B2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PTGFRN | SNV | Missense_Mutation | c.2482N>A | p.Ala828Thr | p.A828T | Q9P2B2 | protein_coding | deleterious(0.01) | possibly_damaging(0.645) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PTGFRN | SNV | Missense_Mutation | c.2387N>T | p.Thr796Ile | p.T796I | Q9P2B2 | protein_coding | deleterious(0.03) | benign(0.152) | TCGA-D5-6929-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatinum+ | SD | |
PTGFRN | SNV | Missense_Mutation | c.2067A>G | p.Ile689Met | p.I689M | Q9P2B2 | protein_coding | tolerated(0.07) | benign(0.129) | TCGA-D5-6931-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PTGFRN | SNV | Missense_Mutation | c.1379C>T | p.Thr460Ile | p.T460I | Q9P2B2 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | |
PTGFRN | SNV | Missense_Mutation | rs372487027 | c.1301N>T | p.Thr434Met | p.T434M | Q9P2B2 | protein_coding | tolerated(0.41) | benign(0.006) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTGFRN | SNV | Missense_Mutation | c.691N>T | p.Arg231Cys | p.R231C | Q9P2B2 | protein_coding | deleterious(0.01) | probably_damaging(0.912) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PTGFRN | SNV | Missense_Mutation | c.1672A>C | p.Lys558Gln | p.K558Q | Q9P2B2 | protein_coding | tolerated(0.06) | possibly_damaging(0.479) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PTGFRN | SNV | Missense_Mutation | novel | c.134T>C | p.Val45Ala | p.V45A | Q9P2B2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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