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Gene: PRRC2A |
Gene summary for PRRC2A |
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Gene information | Species | Human | Gene symbol | PRRC2A | Gene ID | 7916 |
Gene name | proline rich coiled-coil 2A | |
Gene Alias | BAT2 | |
Cytomap | 6p21.33 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A1U9X974 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7916 | PRRC2A | HTA11_347_2000001011 | Human | Colorectum | AD | 4.06e-06 | 2.64e-01 | -0.1954 |
7916 | PRRC2A | HTA11_83_2000001011 | Human | Colorectum | SER | 6.53e-03 | 2.48e-01 | -0.1526 |
7916 | PRRC2A | HTA11_696_2000001011 | Human | Colorectum | AD | 3.43e-08 | 3.90e-01 | -0.1464 |
7916 | PRRC2A | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.74e-06 | 4.53e-01 | -0.059 |
7916 | PRRC2A | HTA11_866_3004761011 | Human | Colorectum | AD | 3.73e-05 | 3.40e-01 | 0.096 |
7916 | PRRC2A | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.98e-04 | 3.61e-01 | 0.0674 |
7916 | PRRC2A | HTA11_11156_2000001011 | Human | Colorectum | AD | 3.83e-03 | 6.30e-01 | 0.0397 |
7916 | PRRC2A | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.60e-07 | 4.69e-01 | 0.0588 |
7916 | PRRC2A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.60e-12 | 5.96e-01 | 0.3859 |
7916 | PRRC2A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.17e-03 | 3.39e-01 | 0.3005 |
7916 | PRRC2A | A015-C-203 | Human | Colorectum | FAP | 2.12e-03 | -8.91e-03 | -0.1294 |
7916 | PRRC2A | A015-C-104 | Human | Colorectum | FAP | 4.94e-04 | -9.28e-02 | -0.1899 |
7916 | PRRC2A | A002-C-116 | Human | Colorectum | FAP | 2.54e-04 | -1.26e-01 | -0.0452 |
7916 | PRRC2A | LZE4T | Human | Esophagus | ESCC | 5.31e-15 | 4.63e-01 | 0.0811 |
7916 | PRRC2A | LZE5T | Human | Esophagus | ESCC | 5.32e-03 | 1.90e-01 | 0.0514 |
7916 | PRRC2A | LZE7T | Human | Esophagus | ESCC | 2.08e-18 | 1.13e+00 | 0.0667 |
7916 | PRRC2A | LZE8T | Human | Esophagus | ESCC | 2.02e-08 | 3.51e-01 | 0.067 |
7916 | PRRC2A | LZE20T | Human | Esophagus | ESCC | 9.79e-09 | 4.72e-01 | 0.0662 |
7916 | PRRC2A | LZE22D1 | Human | Esophagus | HGIN | 1.27e-03 | 1.01e-01 | 0.0595 |
7916 | PRRC2A | LZE22T | Human | Esophagus | ESCC | 4.80e-03 | 3.37e-01 | 0.068 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRRC2A | SNV | Missense_Mutation | rs781324096 | c.3239N>A | p.Arg1080Gln | p.R1080Q | P48634 | protein_coding | deleterious(0) | possibly_damaging(0.799) | TCGA-AA-3855-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PRRC2A | SNV | Missense_Mutation | rs771084827 | c.2338N>T | p.Arg780Trp | p.R780W | P48634 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PRRC2A | SNV | Missense_Mutation | rs745990135 | c.3245N>A | p.Arg1082His | p.R1082H | P48634 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PRRC2A | SNV | Missense_Mutation | rs551639342 | c.3899N>A | p.Arg1300His | p.R1300H | P48634 | protein_coding | tolerated(0.11) | probably_damaging(0.972) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PRRC2A | SNV | Missense_Mutation | c.1763C>T | p.Pro588Leu | p.P588L | P48634 | protein_coding | tolerated(0.1) | benign(0.043) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PRRC2A | SNV | Missense_Mutation | c.1445G>A | p.Arg482His | p.R482H | P48634 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-A02W-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PRRC2A | SNV | Missense_Mutation | rs547605497 | c.5594G>A | p.Arg1865His | p.R1865H | P48634 | protein_coding | deleterious_low_confidence(0) | benign(0.038) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PRRC2A | SNV | Missense_Mutation | c.1178N>A | p.Ala393Glu | p.A393E | P48634 | protein_coding | deleterious(0.01) | benign(0.071) | TCGA-CK-6747-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PRRC2A | SNV | Missense_Mutation | rs748817785 | c.851N>A | p.Arg284His | p.R284H | P48634 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PRRC2A | SNV | Missense_Mutation | c.6170N>T | p.Pro2057Leu | p.P2057L | P48634 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.997) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7916 | PRRC2A | NA | carbamazepine | CARBAMAZEPINE | 16538176 | |
7916 | PRRC2A | NA | carboplatin | CARBOPLATIN | 31616045 | |
7916 | PRRC2A | NA | gemcitabine | GEMCITABINE | 31616045 |
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