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Gene: PRKACB |
Gene summary for PRKACB |
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Gene information | Species | Human | Gene symbol | PRKACB | Gene ID | 5567 |
Gene name | protein kinase cAMP-activated catalytic subunit beta | |
Gene Alias | CAFD2 | |
Cytomap | 1p31.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P22694 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5567 | PRKACB | GSM4909301 | Human | Breast | IDC | 5.38e-24 | 5.90e-01 | 0.1577 |
5567 | PRKACB | M1 | Human | Breast | IDC | 3.69e-02 | 1.62e-01 | 0.1577 |
5567 | PRKACB | NCCBC14 | Human | Breast | DCIS | 5.45e-05 | 3.60e-01 | 0.2021 |
5567 | PRKACB | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.38e-14 | -5.77e-01 | 0.0155 |
5567 | PRKACB | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.17e-02 | -4.29e-01 | -0.1808 |
5567 | PRKACB | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.42e-04 | -5.19e-01 | -0.1207 |
5567 | PRKACB | HTA11_696_2000001011 | Human | Colorectum | AD | 1.79e-04 | -3.41e-01 | -0.1464 |
5567 | PRKACB | HTA11_866_2000001011 | Human | Colorectum | AD | 8.70e-03 | -3.23e-01 | -0.1001 |
5567 | PRKACB | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.66e-05 | -4.40e-01 | -0.059 |
5567 | PRKACB | HTA11_866_3004761011 | Human | Colorectum | AD | 6.29e-08 | -4.82e-01 | 0.096 |
5567 | PRKACB | HTA11_10711_2000001011 | Human | Colorectum | AD | 9.49e-04 | -4.89e-01 | 0.0338 |
5567 | PRKACB | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.02e-15 | -5.17e-01 | 0.0674 |
5567 | PRKACB | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.27e-02 | -4.96e-01 | 0.0588 |
5567 | PRKACB | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.53e-13 | -4.76e-01 | 0.294 |
5567 | PRKACB | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.35e-02 | -4.29e-01 | 0.281 |
5567 | PRKACB | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.30e-22 | -6.06e-01 | 0.3859 |
5567 | PRKACB | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.04e-04 | -5.89e-01 | 0.2585 |
5567 | PRKACB | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.24e-27 | -6.13e-01 | 0.3005 |
5567 | PRKACB | F007 | Human | Colorectum | FAP | 1.10e-03 | -4.24e-01 | 0.1176 |
5567 | PRKACB | A001-C-207 | Human | Colorectum | FAP | 1.12e-02 | -2.87e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005087813 | Breast | IDC | regulation of body fluid levels | 50/1434 | 379/18723 | 1.12e-04 | 2.10e-03 | 50 |
GO:006056212 | Breast | IDC | epithelial tube morphogenesis | 44/1434 | 325/18723 | 1.58e-04 | 2.73e-03 | 44 |
GO:003514812 | Breast | IDC | tube formation | 23/1434 | 148/18723 | 8.79e-04 | 1.02e-02 | 23 |
GO:000183812 | Breast | IDC | embryonic epithelial tube formation | 19/1434 | 121/18723 | 2.10e-03 | 1.97e-02 | 19 |
GO:00721756 | Breast | IDC | epithelial tube formation | 19/1434 | 132/18723 | 5.63e-03 | 4.08e-02 | 19 |
GO:005160413 | Breast | IDC | protein maturation | 35/1434 | 294/18723 | 6.18e-03 | 4.40e-02 | 35 |
GO:005087823 | Breast | DCIS | regulation of body fluid levels | 50/1390 | 379/18723 | 5.17e-05 | 1.06e-03 | 50 |
GO:006056221 | Breast | DCIS | epithelial tube morphogenesis | 41/1390 | 325/18723 | 5.98e-04 | 7.60e-03 | 41 |
GO:003514821 | Breast | DCIS | tube formation | 21/1390 | 148/18723 | 3.08e-03 | 2.62e-02 | 21 |
GO:000183821 | Breast | DCIS | embryonic epithelial tube formation | 18/1390 | 121/18723 | 3.54e-03 | 2.92e-02 | 18 |
GO:005160422 | Breast | DCIS | protein maturation | 34/1390 | 294/18723 | 6.72e-03 | 4.66e-02 | 34 |
GO:00030144 | Breast | DCIS | renal system process | 16/1390 | 110/18723 | 7.16e-03 | 4.85e-02 | 16 |
GO:0050878 | Colorectum | AD | regulation of body fluid levels | 108/3918 | 379/18723 | 2.54e-04 | 3.20e-03 | 108 |
GO:0060562 | Colorectum | AD | epithelial tube morphogenesis | 93/3918 | 325/18723 | 5.65e-04 | 6.00e-03 | 93 |
GO:0051604 | Colorectum | AD | protein maturation | 85/3918 | 294/18723 | 6.73e-04 | 6.91e-03 | 85 |
GO:0014020 | Colorectum | AD | primary neural tube formation | 33/3918 | 94/18723 | 1.02e-03 | 9.50e-03 | 33 |
GO:0001841 | Colorectum | AD | neural tube formation | 35/3918 | 102/18723 | 1.16e-03 | 1.05e-02 | 35 |
GO:0001843 | Colorectum | AD | neural tube closure | 30/3918 | 88/18723 | 2.83e-03 | 2.12e-02 | 30 |
GO:0060606 | Colorectum | AD | tube closure | 30/3918 | 89/18723 | 3.42e-03 | 2.49e-02 | 30 |
GO:0035148 | Colorectum | AD | tube formation | 45/3918 | 148/18723 | 4.13e-03 | 2.87e-02 | 45 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501224 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0502023 | Breast | IDC | Prion disease | 102/867 | 273/8465 | 3.70e-34 | 4.01e-32 | 3.00e-32 | 102 |
hsa0453024 | Breast | IDC | Tight junction | 38/867 | 169/8465 | 2.07e-06 | 3.20e-05 | 2.39e-05 | 38 |
hsa0520523 | Breast | IDC | Proteoglycans in cancer | 42/867 | 205/8465 | 7.69e-06 | 9.99e-05 | 7.48e-05 | 42 |
hsa0520322 | Breast | IDC | Viral carcinogenesis | 34/867 | 204/8465 | 2.82e-03 | 1.86e-02 | 1.39e-02 | 34 |
hsa049704 | Breast | IDC | Salivary secretion | 18/867 | 93/8465 | 5.69e-03 | 3.13e-02 | 2.34e-02 | 18 |
hsa0501234 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0502033 | Breast | IDC | Prion disease | 102/867 | 273/8465 | 3.70e-34 | 4.01e-32 | 3.00e-32 | 102 |
hsa0453034 | Breast | IDC | Tight junction | 38/867 | 169/8465 | 2.07e-06 | 3.20e-05 | 2.39e-05 | 38 |
hsa0520533 | Breast | IDC | Proteoglycans in cancer | 42/867 | 205/8465 | 7.69e-06 | 9.99e-05 | 7.48e-05 | 42 |
hsa0520332 | Breast | IDC | Viral carcinogenesis | 34/867 | 204/8465 | 2.82e-03 | 1.86e-02 | 1.39e-02 | 34 |
hsa0497011 | Breast | IDC | Salivary secretion | 18/867 | 93/8465 | 5.69e-03 | 3.13e-02 | 2.34e-02 | 18 |
hsa0501243 | Breast | DCIS | Parkinson disease | 106/846 | 266/8465 | 1.64e-39 | 5.29e-37 | 3.90e-37 | 106 |
hsa0502043 | Breast | DCIS | Prion disease | 100/846 | 273/8465 | 1.44e-33 | 1.55e-31 | 1.14e-31 | 100 |
hsa0471443 | Breast | DCIS | Thermogenesis | 74/846 | 232/8465 | 8.72e-21 | 3.13e-19 | 2.30e-19 | 74 |
hsa0491542 | Breast | DCIS | Estrogen signaling pathway | 35/846 | 138/8465 | 1.40e-07 | 2.51e-06 | 1.85e-06 | 35 |
hsa0453044 | Breast | DCIS | Tight junction | 37/846 | 169/8465 | 3.07e-06 | 4.20e-05 | 3.09e-05 | 37 |
hsa0511041 | Breast | DCIS | Vibrio cholerae infection | 17/846 | 50/8465 | 3.45e-06 | 4.45e-05 | 3.28e-05 | 17 |
hsa0520542 | Breast | DCIS | Proteoglycans in cancer | 39/846 | 205/8465 | 5.36e-05 | 5.58e-04 | 4.11e-04 | 39 |
hsa0516642 | Breast | DCIS | Human T-cell leukemia virus 1 infection | 41/846 | 222/8465 | 7.03e-05 | 6.88e-04 | 5.07e-04 | 41 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRKACB | SNV | Missense_Mutation | novel | c.685N>A | p.Gln229Lys | p.Q229K | P22694 | protein_coding | tolerated(1) | benign(0.007) | TCGA-78-7148-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PRKACB | SNV | Missense_Mutation | novel | c.1082C>A | p.Pro361Gln | p.P361Q | P22694 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-78-7536-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
PRKACB | SNV | Missense_Mutation | c.1138N>C | p.Glu380Gln | p.E380Q | P22694 | protein_coding | deleterious(0.01) | benign(0.269) | TCGA-78-7539-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
PRKACB | SNV | Missense_Mutation | novel | c.1133A>C | p.Tyr378Ser | p.Y378S | P22694 | protein_coding | deleterious(0.01) | benign(0.411) | TCGA-95-A4VN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRKACB | SNV | Missense_Mutation | novel | c.799N>T | p.Val267Leu | p.V267L | P22694 | protein_coding | deleterious(0) | probably_damaging(0.926) | TCGA-97-A4LX-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PRKACB | SNV | Missense_Mutation | c.701N>T | p.Gly234Val | p.G234V | P22694 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-18-3414-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PRKACB | SNV | Missense_Mutation | rs757439493 | c.953G>A | p.Arg318Gln | p.R318Q | P22694 | protein_coding | tolerated(0.17) | benign(0.017) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PRKACB | SNV | Missense_Mutation | novel | c.797C>T | p.Ala266Val | p.A266V | P22694 | protein_coding | deleterious(0) | possibly_damaging(0.571) | TCGA-92-7340-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
PRKACB | SNV | Missense_Mutation | c.542G>A | p.Arg181Lys | p.R181K | P22694 | protein_coding | deleterious(0.02) | benign(0.048) | TCGA-CR-6481-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD | |
PRKACB | SNV | Missense_Mutation | novel | c.850C>T | p.Pro284Ser | p.P284S | P22694 | protein_coding | tolerated(0.06) | possibly_damaging(0.545) | TCGA-CR-7398-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5567 | PRKACB | ENZYME, KINASE, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | 178101884 | GSK-690693 | |
5567 | PRKACB | ENZYME, KINASE, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, SERINE THREONINE KINASE | FASUDIL | FASUDIL | 22257127 | |
5567 | PRKACB | ENZYME, KINASE, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | 135652717 | STAUROSPORINE | |
5567 | PRKACB | ENZYME, KINASE, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | CHEMBL494089 | GSK-690693 |
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