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Gene: PQLC2 |
Gene summary for PQLC2 |
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Gene information | Species | Human | Gene symbol | PQLC2 | Gene ID | 54896 |
Gene name | solute carrier family 66 member 1 | |
Gene Alias | LAAT-1 | |
Cytomap | 1p36.13 | |
Gene Type | protein-coding | GO ID | GO:0003333 | UniProtAcc | A0A024RA97 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54896 | PQLC2 | P1T-E | Human | Esophagus | ESCC | 4.62e-03 | 1.54e-01 | 0.0875 |
54896 | PQLC2 | P2T-E | Human | Esophagus | ESCC | 1.69e-16 | 2.75e-01 | 0.1177 |
54896 | PQLC2 | P4T-E | Human | Esophagus | ESCC | 6.14e-11 | 2.24e-01 | 0.1323 |
54896 | PQLC2 | P5T-E | Human | Esophagus | ESCC | 3.97e-04 | 9.61e-02 | 0.1327 |
54896 | PQLC2 | P8T-E | Human | Esophagus | ESCC | 9.35e-10 | 1.71e-01 | 0.0889 |
54896 | PQLC2 | P9T-E | Human | Esophagus | ESCC | 2.41e-06 | 1.58e-01 | 0.1131 |
54896 | PQLC2 | P10T-E | Human | Esophagus | ESCC | 7.31e-14 | 2.80e-01 | 0.116 |
54896 | PQLC2 | P11T-E | Human | Esophagus | ESCC | 1.13e-06 | 2.55e-01 | 0.1426 |
54896 | PQLC2 | P12T-E | Human | Esophagus | ESCC | 7.31e-14 | 2.61e-01 | 0.1122 |
54896 | PQLC2 | P15T-E | Human | Esophagus | ESCC | 2.31e-15 | 2.79e-01 | 0.1149 |
54896 | PQLC2 | P16T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.20e-01 | 0.1153 |
54896 | PQLC2 | P17T-E | Human | Esophagus | ESCC | 1.49e-05 | 2.27e-01 | 0.1278 |
54896 | PQLC2 | P19T-E | Human | Esophagus | ESCC | 2.24e-09 | 5.35e-01 | 0.1662 |
54896 | PQLC2 | P20T-E | Human | Esophagus | ESCC | 4.83e-12 | 2.69e-01 | 0.1124 |
54896 | PQLC2 | P21T-E | Human | Esophagus | ESCC | 2.25e-22 | 4.35e-01 | 0.1617 |
54896 | PQLC2 | P22T-E | Human | Esophagus | ESCC | 9.02e-11 | 2.07e-01 | 0.1236 |
54896 | PQLC2 | P23T-E | Human | Esophagus | ESCC | 6.47e-17 | 3.58e-01 | 0.108 |
54896 | PQLC2 | P24T-E | Human | Esophagus | ESCC | 4.12e-11 | 2.19e-01 | 0.1287 |
54896 | PQLC2 | P26T-E | Human | Esophagus | ESCC | 5.79e-16 | 2.17e-01 | 0.1276 |
54896 | PQLC2 | P27T-E | Human | Esophagus | ESCC | 7.30e-09 | 2.33e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PQLC2 | SNV | Missense_Mutation | rs199786682 | c.493N>T | p.Arg165Trp | p.R165W | Q6ZP29 | protein_coding | deleterious(0.02) | benign(0.059) | TCGA-BR-8081-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PQLC2 | SNV | Missense_Mutation | rs763092892 | c.428N>T | p.Ala143Val | p.A143V | Q6ZP29 | protein_coding | tolerated(1) | benign(0) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PQLC2 | SNV | Missense_Mutation | c.731N>T | p.Ser244Ile | p.S244I | Q6ZP29 | protein_coding | tolerated(0.18) | benign(0.065) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PQLC2 | SNV | Missense_Mutation | c.596N>T | p.Arg199Leu | p.R199L | Q6ZP29 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CG-4437-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PQLC2 | SNV | Missense_Mutation | rs756272440 | c.683N>T | p.Thr228Met | p.T228M | Q6ZP29 | protein_coding | tolerated(0.15) | benign(0.067) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
PQLC2 | SNV | Missense_Mutation | c.661N>A | p.Ala221Thr | p.A221T | Q6ZP29 | protein_coding | deleterious(0.01) | benign(0.322) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
PQLC2 | SNV | Missense_Mutation | rs771330075 | c.497N>T | p.Ala166Val | p.A166V | Q6ZP29 | protein_coding | tolerated(0.28) | benign(0.007) | TCGA-VQ-A8PX-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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