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Gene: PPP2R3A |
Gene summary for PPP2R3A |
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Gene information | Species | Human | Gene symbol | PPP2R3A | Gene ID | 5523 |
Gene name | protein phosphatase 2 regulatory subunit B''alpha | |
Gene Alias | PPP2R3 | |
Cytomap | 3q22.2-q22.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q06190 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5523 | PPP2R3A | CCI_1 | Human | Cervix | CC | 9.68e-08 | 8.40e-01 | 0.528 |
5523 | PPP2R3A | CCI_2 | Human | Cervix | CC | 5.43e-04 | 1.44e+00 | 0.5249 |
5523 | PPP2R3A | CCI_3 | Human | Cervix | CC | 3.57e-30 | 1.51e+00 | 0.516 |
5523 | PPP2R3A | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.79e-25 | -7.04e-01 | 0.0155 |
5523 | PPP2R3A | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.09e-05 | -5.09e-01 | -0.1808 |
5523 | PPP2R3A | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.97e-05 | -8.59e-01 | 0.0216 |
5523 | PPP2R3A | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.23e-02 | -6.83e-01 | -0.2196 |
5523 | PPP2R3A | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.29e-07 | -5.97e-01 | -0.1207 |
5523 | PPP2R3A | HTA11_696_2000001011 | Human | Colorectum | AD | 1.45e-08 | -4.34e-01 | -0.1464 |
5523 | PPP2R3A | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.03e-05 | -4.08e-01 | -0.059 |
5523 | PPP2R3A | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.45e-02 | -6.16e-01 | -0.1706 |
5523 | PPP2R3A | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.55e-03 | -6.46e-01 | -0.2061 |
5523 | PPP2R3A | HTA11_866_3004761011 | Human | Colorectum | AD | 4.08e-23 | -7.73e-01 | 0.096 |
5523 | PPP2R3A | HTA11_9408_2000001011 | Human | Colorectum | AD | 6.13e-04 | -8.85e-01 | 0.0451 |
5523 | PPP2R3A | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.30e-05 | -7.65e-01 | 0.0528 |
5523 | PPP2R3A | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.08e-11 | -6.87e-01 | 0.0338 |
5523 | PPP2R3A | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.15e-20 | -6.68e-01 | 0.0674 |
5523 | PPP2R3A | HTA11_6818_2000001021 | Human | Colorectum | AD | 5.94e-03 | -5.19e-01 | 0.0588 |
5523 | PPP2R3A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.12e-30 | -7.52e-01 | 0.294 |
5523 | PPP2R3A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.34e-06 | -5.97e-01 | 0.281 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064708 | Cervix | CC | protein dephosphorylation | 60/2311 | 281/18723 | 1.33e-05 | 2.68e-04 | 60 |
GO:00163117 | Cervix | CC | dephosphorylation | 73/2311 | 417/18723 | 1.23e-03 | 9.87e-03 | 73 |
GO:0016311 | Colorectum | AD | dephosphorylation | 123/3918 | 417/18723 | 1.84e-05 | 3.82e-04 | 123 |
GO:0006470 | Colorectum | AD | protein dephosphorylation | 88/3918 | 281/18723 | 2.56e-05 | 4.89e-04 | 88 |
GO:00064701 | Colorectum | SER | protein dephosphorylation | 65/2897 | 281/18723 | 4.44e-04 | 6.51e-03 | 65 |
GO:00163111 | Colorectum | SER | dephosphorylation | 86/2897 | 417/18723 | 2.73e-03 | 2.46e-02 | 86 |
GO:00064702 | Colorectum | MSS | protein dephosphorylation | 73/3467 | 281/18723 | 1.15e-03 | 1.12e-02 | 73 |
GO:00163112 | Colorectum | MSS | dephosphorylation | 101/3467 | 417/18723 | 1.98e-03 | 1.70e-02 | 101 |
GO:00163113 | Colorectum | FAP | dephosphorylation | 95/2622 | 417/18723 | 7.07e-07 | 3.32e-05 | 95 |
GO:00064704 | Colorectum | FAP | protein dephosphorylation | 69/2622 | 281/18723 | 1.47e-06 | 6.39e-05 | 69 |
GO:00163114 | Colorectum | CRC | dephosphorylation | 79/2078 | 417/18723 | 1.27e-06 | 7.21e-05 | 79 |
GO:00064705 | Colorectum | CRC | protein dephosphorylation | 57/2078 | 281/18723 | 4.49e-06 | 1.87e-04 | 57 |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:000647018 | Esophagus | ESCC | protein dephosphorylation | 177/8552 | 281/18723 | 3.13e-09 | 6.72e-08 | 177 |
GO:00064707 | Lung | IAC | protein dephosphorylation | 60/2061 | 281/18723 | 3.24e-07 | 2.48e-05 | 60 |
GO:00163116 | Lung | IAC | dephosphorylation | 75/2061 | 417/18723 | 1.21e-05 | 3.64e-04 | 75 |
GO:000647012 | Lung | AIS | protein dephosphorylation | 56/1849 | 281/18723 | 2.47e-07 | 2.24e-05 | 56 |
GO:001631112 | Lung | AIS | dephosphorylation | 69/1849 | 417/18723 | 1.27e-05 | 4.78e-04 | 69 |
GO:000647015 | Oral cavity | OSCC | protein dephosphorylation | 162/7305 | 281/18723 | 1.56e-10 | 4.56e-09 | 162 |
GO:00163119 | Oral cavity | OSCC | dephosphorylation | 220/7305 | 417/18723 | 6.33e-09 | 1.34e-07 | 220 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0407110 | Cervix | CC | Sphingolipid signaling pathway | 35/1267 | 121/8465 | 5.70e-05 | 3.93e-04 | 2.32e-04 | 35 |
hsa051657 | Cervix | CC | Human papillomavirus infection | 74/1267 | 331/8465 | 1.70e-04 | 1.02e-03 | 6.03e-04 | 74 |
hsa0407113 | Cervix | CC | Sphingolipid signaling pathway | 35/1267 | 121/8465 | 5.70e-05 | 3.93e-04 | 2.32e-04 | 35 |
hsa0516512 | Cervix | CC | Human papillomavirus infection | 74/1267 | 331/8465 | 1.70e-04 | 1.02e-03 | 6.03e-04 | 74 |
hsa04152 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa04071 | Colorectum | AD | Sphingolipid signaling pathway | 43/2092 | 121/8465 | 4.83e-03 | 2.28e-02 | 1.45e-02 | 43 |
hsa04728 | Colorectum | AD | Dopaminergic synapse | 46/2092 | 132/8465 | 5.55e-03 | 2.48e-02 | 1.58e-02 | 46 |
hsa03015 | Colorectum | AD | mRNA surveillance pathway | 35/2092 | 97/8465 | 7.95e-03 | 3.13e-02 | 2.00e-02 | 35 |
hsa041521 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa040711 | Colorectum | AD | Sphingolipid signaling pathway | 43/2092 | 121/8465 | 4.83e-03 | 2.28e-02 | 1.45e-02 | 43 |
hsa047281 | Colorectum | AD | Dopaminergic synapse | 46/2092 | 132/8465 | 5.55e-03 | 2.48e-02 | 1.58e-02 | 46 |
hsa030151 | Colorectum | AD | mRNA surveillance pathway | 35/2092 | 97/8465 | 7.95e-03 | 3.13e-02 | 2.00e-02 | 35 |
hsa047282 | Colorectum | SER | Dopaminergic synapse | 37/1580 | 132/8465 | 5.27e-03 | 3.28e-02 | 2.38e-02 | 37 |
hsa047283 | Colorectum | SER | Dopaminergic synapse | 37/1580 | 132/8465 | 5.27e-03 | 3.28e-02 | 2.38e-02 | 37 |
hsa047284 | Colorectum | MSS | Dopaminergic synapse | 45/1875 | 132/8465 | 1.02e-03 | 5.94e-03 | 3.64e-03 | 45 |
hsa041522 | Colorectum | MSS | AMPK signaling pathway | 41/1875 | 121/8465 | 1.91e-03 | 9.83e-03 | 6.03e-03 | 41 |
hsa040712 | Colorectum | MSS | Sphingolipid signaling pathway | 40/1875 | 121/8465 | 3.56e-03 | 1.64e-02 | 1.01e-02 | 40 |
hsa047285 | Colorectum | MSS | Dopaminergic synapse | 45/1875 | 132/8465 | 1.02e-03 | 5.94e-03 | 3.64e-03 | 45 |
hsa041523 | Colorectum | MSS | AMPK signaling pathway | 41/1875 | 121/8465 | 1.91e-03 | 9.83e-03 | 6.03e-03 | 41 |
hsa040713 | Colorectum | MSS | Sphingolipid signaling pathway | 40/1875 | 121/8465 | 3.56e-03 | 1.64e-02 | 1.01e-02 | 40 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPP2R3A | SNV | Missense_Mutation | rs147986508 | c.2600N>T | p.Ser867Leu | p.S867L | Q06190 | protein_coding | tolerated(1) | benign(0) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PPP2R3A | SNV | Missense_Mutation | c.2795N>T | p.Ser932Leu | p.S932L | Q06190 | protein_coding | deleterious(0) | probably_damaging(0.934) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PPP2R3A | SNV | Missense_Mutation | novel | c.1220N>A | p.Ser407Tyr | p.S407Y | Q06190 | protein_coding | deleterious_low_confidence(0.01) | benign(0.254) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
PPP2R3A | SNV | Missense_Mutation | novel | c.569N>T | p.Arg190Ile | p.R190I | Q06190 | protein_coding | tolerated_low_confidence(0.22) | benign(0.009) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PPP2R3A | SNV | Missense_Mutation | c.1588N>G | p.Pro530Ala | p.P530A | Q06190 | protein_coding | deleterious_low_confidence(0) | benign(0.388) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PPP2R3A | SNV | Missense_Mutation | novel | c.1948N>T | p.Asp650Tyr | p.D650Y | Q06190 | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PPP2R3A | deletion | Frame_Shift_Del | novel | c.735delA | p.Lys245AsnfsTer6 | p.K245Nfs*6 | Q06190 | protein_coding | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
PPP2R3A | insertion | In_Frame_Ins | novel | c.893_894insTTGTTTTATGAT | p.Gln298delinsHisCysPheMetMet | p.Q298delinsHCFMM | Q06190 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PPP2R3A | deletion | Frame_Shift_Del | novel | c.1816_1823delNNNNNNNN | p.Val606GlnfsTer33 | p.V606Qfs*33 | Q06190 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PPP2R3A | insertion | Frame_Shift_Ins | novel | c.90_91insTG | p.Thr32AlafsTer38 | p.T32Afs*38 | Q06190 | protein_coding | TCGA-AG-A014-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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