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Gene: PLAGL2 |
Gene summary for PLAGL2 |
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Gene information | Species | Human | Gene symbol | PLAGL2 | Gene ID | 5326 |
Gene name | PLAG1 like zinc finger 2 | |
Gene Alias | ZNF900 | |
Cytomap | 20q11.21 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9UPG8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5326 | PLAGL2 | LZE24T | Human | Esophagus | ESCC | 1.54e-18 | 5.16e-01 | 0.0596 |
5326 | PLAGL2 | P1T-E | Human | Esophagus | ESCC | 1.64e-02 | 1.67e-01 | 0.0875 |
5326 | PLAGL2 | P2T-E | Human | Esophagus | ESCC | 2.04e-13 | 2.57e-01 | 0.1177 |
5326 | PLAGL2 | P4T-E | Human | Esophagus | ESCC | 1.85e-08 | 2.72e-01 | 0.1323 |
5326 | PLAGL2 | P5T-E | Human | Esophagus | ESCC | 5.08e-11 | 1.87e-01 | 0.1327 |
5326 | PLAGL2 | P8T-E | Human | Esophagus | ESCC | 7.38e-24 | 6.21e-01 | 0.0889 |
5326 | PLAGL2 | P9T-E | Human | Esophagus | ESCC | 3.90e-02 | 1.20e-01 | 0.1131 |
5326 | PLAGL2 | P10T-E | Human | Esophagus | ESCC | 5.06e-18 | 2.54e-01 | 0.116 |
5326 | PLAGL2 | P11T-E | Human | Esophagus | ESCC | 3.69e-02 | 1.81e-01 | 0.1426 |
5326 | PLAGL2 | P12T-E | Human | Esophagus | ESCC | 4.14e-20 | 3.90e-01 | 0.1122 |
5326 | PLAGL2 | P15T-E | Human | Esophagus | ESCC | 5.26e-18 | 2.90e-01 | 0.1149 |
5326 | PLAGL2 | P16T-E | Human | Esophagus | ESCC | 1.93e-17 | 1.79e-01 | 0.1153 |
5326 | PLAGL2 | P20T-E | Human | Esophagus | ESCC | 2.07e-06 | 1.71e-01 | 0.1124 |
5326 | PLAGL2 | P21T-E | Human | Esophagus | ESCC | 3.76e-14 | 2.94e-01 | 0.1617 |
5326 | PLAGL2 | P22T-E | Human | Esophagus | ESCC | 5.55e-10 | 1.05e-01 | 0.1236 |
5326 | PLAGL2 | P23T-E | Human | Esophagus | ESCC | 4.97e-14 | 3.63e-01 | 0.108 |
5326 | PLAGL2 | P24T-E | Human | Esophagus | ESCC | 8.90e-06 | 7.03e-02 | 0.1287 |
5326 | PLAGL2 | P26T-E | Human | Esophagus | ESCC | 8.03e-32 | 5.84e-01 | 0.1276 |
5326 | PLAGL2 | P27T-E | Human | Esophagus | ESCC | 1.88e-14 | 1.64e-01 | 0.1055 |
5326 | PLAGL2 | P28T-E | Human | Esophagus | ESCC | 6.61e-35 | 7.55e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0097193111 | Esophagus | ESCC | intrinsic apoptotic signaling pathway | 222/8552 | 288/18723 | 5.87e-28 | 2.02e-25 | 222 |
GO:2001233111 | Esophagus | ESCC | regulation of apoptotic signaling pathway | 256/8552 | 356/18723 | 4.11e-24 | 1.04e-21 | 256 |
GO:2001242111 | Esophagus | ESCC | regulation of intrinsic apoptotic signaling pathway | 128/8552 | 164/18723 | 1.75e-17 | 1.50e-15 | 128 |
GO:2001235110 | Esophagus | ESCC | positive regulation of apoptotic signaling pathway | 92/8552 | 126/18723 | 3.91e-10 | 1.05e-08 | 92 |
GO:00097919 | Esophagus | ESCC | post-embryonic development | 56/8552 | 80/18723 | 9.08e-06 | 8.71e-05 | 56 |
GO:200124417 | Esophagus | ESCC | positive regulation of intrinsic apoptotic signaling pathway | 43/8552 | 58/18723 | 9.86e-06 | 9.37e-05 | 43 |
GO:200123320 | Oral cavity | OSCC | regulation of apoptotic signaling pathway | 242/7305 | 356/18723 | 6.66e-29 | 3.24e-26 | 242 |
GO:009719320 | Oral cavity | OSCC | intrinsic apoptotic signaling pathway | 202/7305 | 288/18723 | 4.64e-27 | 1.73e-24 | 202 |
GO:200124220 | Oral cavity | OSCC | regulation of intrinsic apoptotic signaling pathway | 123/7305 | 164/18723 | 5.71e-21 | 9.77e-19 | 123 |
GO:200123510 | Oral cavity | OSCC | positive regulation of apoptotic signaling pathway | 92/7305 | 126/18723 | 8.45e-15 | 5.19e-13 | 92 |
GO:20012449 | Oral cavity | OSCC | positive regulation of intrinsic apoptotic signaling pathway | 44/7305 | 58/18723 | 1.22e-08 | 2.48e-07 | 44 |
GO:00097918 | Oral cavity | OSCC | post-embryonic development | 51/7305 | 80/18723 | 6.43e-06 | 7.13e-05 | 51 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLAGL2 | SNV | Missense_Mutation | c.1186C>T | p.Leu396Phe | p.L396F | Q9UPG8 | protein_coding | deleterious(0.01) | possibly_damaging(0.672) | TCGA-44-A4SU-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PLAGL2 | SNV | Missense_Mutation | c.716N>G | p.Lys239Arg | p.K239R | Q9UPG8 | protein_coding | tolerated(0.17) | probably_damaging(0.999) | TCGA-50-6594-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
PLAGL2 | SNV | Missense_Mutation | c.511N>A | p.Leu171Met | p.L171M | Q9UPG8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-1595-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PLAGL2 | SNV | Missense_Mutation | c.969N>C | p.Met323Ile | p.M323I | Q9UPG8 | protein_coding | tolerated(0.47) | benign(0.119) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PLAGL2 | SNV | Missense_Mutation | novel | c.787A>T | p.Ser263Cys | p.S263C | Q9UPG8 | protein_coding | tolerated(0.18) | possibly_damaging(0.765) | TCGA-97-8172-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLAGL2 | SNV | Missense_Mutation | c.716A>G | p.Lys239Arg | p.K239R | Q9UPG8 | protein_coding | tolerated(0.17) | probably_damaging(0.999) | TCGA-18-3417-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | SD | |
PLAGL2 | SNV | Missense_Mutation | c.1370N>A | p.Pro457His | p.P457H | Q9UPG8 | protein_coding | tolerated(0.09) | possibly_damaging(0.907) | TCGA-22-5482-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PLAGL2 | SNV | Missense_Mutation | novel | c.772N>T | p.Gly258Cys | p.G258C | Q9UPG8 | protein_coding | deleterious(0.01) | possibly_damaging(0.873) | TCGA-34-2604-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLAGL2 | SNV | Missense_Mutation | novel | c.1469G>A | p.Arg490His | p.R490H | Q9UPG8 | protein_coding | tolerated(0.42) | probably_damaging(0.991) | TCGA-CR-5243-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
PLAGL2 | SNV | Missense_Mutation | novel | c.853N>T | p.Gly285Trp | p.G285W | Q9UPG8 | protein_coding | deleterious(0.04) | possibly_damaging(0.682) | TCGA-CR-7388-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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