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Gene: PLAG1 |
Gene summary for PLAG1 |
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Gene information | Species | Human | Gene symbol | PLAG1 | Gene ID | 5324 |
Gene name | PLAG1 zinc finger | |
Gene Alias | PSA | |
Cytomap | 8q12.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R7Z0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5324 | PLAG1 | LZE2T | Human | Esophagus | ESCC | 1.52e-08 | 5.56e-01 | 0.082 |
5324 | PLAG1 | LZE20T | Human | Esophagus | ESCC | 5.57e-10 | 2.76e-01 | 0.0662 |
5324 | PLAG1 | LZE22T | Human | Esophagus | ESCC | 1.57e-03 | 2.17e-01 | 0.068 |
5324 | PLAG1 | LZE24T | Human | Esophagus | ESCC | 7.60e-20 | 4.50e-01 | 0.0596 |
5324 | PLAG1 | P1T-E | Human | Esophagus | ESCC | 2.44e-06 | 2.72e-01 | 0.0875 |
5324 | PLAG1 | P2T-E | Human | Esophagus | ESCC | 6.62e-20 | 3.20e-01 | 0.1177 |
5324 | PLAG1 | P4T-E | Human | Esophagus | ESCC | 4.13e-17 | 3.34e-01 | 0.1323 |
5324 | PLAG1 | P8T-E | Human | Esophagus | ESCC | 9.67e-18 | 2.95e-01 | 0.0889 |
5324 | PLAG1 | P10T-E | Human | Esophagus | ESCC | 1.23e-20 | 3.86e-01 | 0.116 |
5324 | PLAG1 | P12T-E | Human | Esophagus | ESCC | 1.76e-12 | 2.28e-01 | 0.1122 |
5324 | PLAG1 | P15T-E | Human | Esophagus | ESCC | 2.13e-05 | 1.40e-01 | 0.1149 |
5324 | PLAG1 | P16T-E | Human | Esophagus | ESCC | 4.16e-22 | 3.54e-01 | 0.1153 |
5324 | PLAG1 | P17T-E | Human | Esophagus | ESCC | 1.49e-02 | 1.68e-01 | 0.1278 |
5324 | PLAG1 | P20T-E | Human | Esophagus | ESCC | 6.15e-13 | 2.79e-01 | 0.1124 |
5324 | PLAG1 | P22T-E | Human | Esophagus | ESCC | 1.62e-13 | 2.47e-01 | 0.1236 |
5324 | PLAG1 | P23T-E | Human | Esophagus | ESCC | 6.91e-16 | 3.57e-01 | 0.108 |
5324 | PLAG1 | P24T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.73e-01 | 0.1287 |
5324 | PLAG1 | P26T-E | Human | Esophagus | ESCC | 2.39e-24 | 4.72e-01 | 0.1276 |
5324 | PLAG1 | P27T-E | Human | Esophagus | ESCC | 3.02e-26 | 4.26e-01 | 0.1055 |
5324 | PLAG1 | P30T-E | Human | Esophagus | ESCC | 1.56e-07 | 3.50e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048732111 | Esophagus | ESCC | gland development | 269/8552 | 436/18723 | 7.81e-12 | 2.95e-10 | 269 |
GO:0061458110 | Esophagus | ESCC | reproductive system development | 247/8552 | 427/18723 | 2.24e-07 | 3.42e-06 | 247 |
GO:004860818 | Esophagus | ESCC | reproductive structure development | 245/8552 | 424/18723 | 2.82e-07 | 4.14e-06 | 245 |
GO:002261216 | Esophagus | ESCC | gland morphogenesis | 78/8552 | 118/18723 | 5.83e-06 | 6.03e-05 | 78 |
GO:001072010 | Esophagus | ESCC | positive regulation of cell development | 172/8552 | 298/18723 | 1.74e-05 | 1.55e-04 | 172 |
GO:00420636 | Esophagus | ESCC | gliogenesis | 172/8552 | 301/18723 | 3.75e-05 | 3.04e-04 | 172 |
GO:005076710 | Esophagus | ESCC | regulation of neurogenesis | 203/8552 | 364/18723 | 6.10e-05 | 4.68e-04 | 203 |
GO:00140091 | Esophagus | ESCC | glial cell proliferation | 37/8552 | 51/18723 | 9.01e-05 | 6.50e-04 | 37 |
GO:00507697 | Esophagus | ESCC | positive regulation of neurogenesis | 131/8552 | 225/18723 | 9.71e-05 | 6.90e-04 | 131 |
GO:00352647 | Esophagus | ESCC | multicellular organism growth | 80/8552 | 132/18723 | 3.84e-04 | 2.22e-03 | 80 |
GO:00308506 | Esophagus | ESCC | prostate gland development | 32/8552 | 45/18723 | 4.87e-04 | 2.70e-03 | 32 |
GO:00519606 | Esophagus | ESCC | regulation of nervous system development | 237/8552 | 443/18723 | 5.02e-04 | 2.78e-03 | 237 |
GO:00519625 | Esophagus | ESCC | positive regulation of nervous system development | 149/8552 | 272/18723 | 1.50e-03 | 7.06e-03 | 149 |
GO:00602511 | Esophagus | ESCC | regulation of glial cell proliferation | 25/8552 | 36/18723 | 3.39e-03 | 1.39e-02 | 25 |
GO:00140151 | Esophagus | ESCC | positive regulation of gliogenesis | 41/8552 | 66/18723 | 5.22e-03 | 1.97e-02 | 41 |
GO:00016559 | Esophagus | ESCC | urogenital system development | 177/8552 | 338/18723 | 7.51e-03 | 2.69e-02 | 177 |
GO:00602521 | Esophagus | ESCC | positive regulation of glial cell proliferation | 15/8552 | 20/18723 | 7.60e-03 | 2.71e-02 | 15 |
GO:00140131 | Esophagus | ESCC | regulation of gliogenesis | 59/8552 | 103/18723 | 1.17e-02 | 3.91e-02 | 59 |
GO:004873220 | Oral cavity | OSCC | gland development | 226/7305 | 436/18723 | 2.78e-08 | 5.39e-07 | 226 |
GO:00107209 | Oral cavity | OSCC | positive regulation of cell development | 159/7305 | 298/18723 | 3.06e-07 | 4.66e-06 | 159 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLAG1 | SNV | Missense_Mutation | rs771690216 | c.370G>A | p.Glu124Lys | p.E124K | Q6DJT9 | protein_coding | tolerated(0.07) | benign(0.166) | TCGA-G5-6641-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
PLAG1 | deletion | Frame_Shift_Del | c.551delN | p.Lys184SerfsTer45 | p.K184Sfs*45 | Q6DJT9 | protein_coding | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |||
PLAG1 | SNV | Missense_Mutation | novel | c.679C>A | p.His227Asn | p.H227N | Q6DJT9 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLAG1 | SNV | Missense_Mutation | novel | c.1129N>C | p.Ser377Pro | p.S377P | Q6DJT9 | protein_coding | tolerated(0.48) | benign(0.001) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLAG1 | SNV | Missense_Mutation | rs867214774 | c.1004N>T | p.Pro335Leu | p.P335L | Q6DJT9 | protein_coding | tolerated(0.22) | possibly_damaging(0.716) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
PLAG1 | SNV | Missense_Mutation | novel | c.929C>A | p.Thr310Asn | p.T310N | Q6DJT9 | protein_coding | tolerated(0.33) | benign(0.01) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLAG1 | SNV | Missense_Mutation | novel | c.416A>G | p.His139Arg | p.H139R | Q6DJT9 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLAG1 | SNV | Missense_Mutation | novel | c.1472N>T | p.Thr491Ile | p.T491I | Q6DJT9 | protein_coding | tolerated(0.28) | benign(0.078) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
PLAG1 | SNV | Missense_Mutation | novel | c.817N>T | p.Pro273Ser | p.P273S | Q6DJT9 | protein_coding | tolerated(0.24) | benign(0.001) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
PLAG1 | SNV | Missense_Mutation | c.445N>T | p.Asp149Tyr | p.D149Y | Q6DJT9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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