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Gene: PIM2 |
Gene summary for PIM2 |
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Gene information | Species | Human | Gene symbol | PIM2 | Gene ID | 11040 |
Gene name | Pim-2 proto-oncogene, serine/threonine kinase | |
Gene Alias | PIM2 | |
Cytomap | Xp11.23 | |
Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | A0A024QYW7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11040 | PIM2 | LZE4T | Human | Esophagus | ESCC | 6.44e-05 | 2.95e-01 | 0.0811 |
11040 | PIM2 | LZE7T | Human | Esophagus | ESCC | 3.68e-10 | 5.88e-01 | 0.0667 |
11040 | PIM2 | LZE8T | Human | Esophagus | ESCC | 1.53e-05 | 3.15e-01 | 0.067 |
11040 | PIM2 | LZE20T | Human | Esophagus | ESCC | 4.72e-04 | 1.98e-01 | 0.0662 |
11040 | PIM2 | LZE22D1 | Human | Esophagus | HGIN | 1.34e-02 | 3.28e-01 | 0.0595 |
11040 | PIM2 | LZE24T | Human | Esophagus | ESCC | 7.64e-03 | 1.25e-01 | 0.0596 |
11040 | PIM2 | LZE21T | Human | Esophagus | ESCC | 6.08e-05 | 3.55e-01 | 0.0655 |
11040 | PIM2 | LZE6T | Human | Esophagus | ESCC | 2.28e-05 | 3.79e-01 | 0.0845 |
11040 | PIM2 | P1T-E | Human | Esophagus | ESCC | 4.45e-03 | 1.53e-01 | 0.0875 |
11040 | PIM2 | P2T-E | Human | Esophagus | ESCC | 7.65e-20 | 3.38e-01 | 0.1177 |
11040 | PIM2 | P4T-E | Human | Esophagus | ESCC | 1.12e-13 | 3.08e-01 | 0.1323 |
11040 | PIM2 | P5T-E | Human | Esophagus | ESCC | 1.83e-12 | 3.14e-01 | 0.1327 |
11040 | PIM2 | P8T-E | Human | Esophagus | ESCC | 1.19e-09 | 1.82e-01 | 0.0889 |
11040 | PIM2 | P9T-E | Human | Esophagus | ESCC | 4.18e-06 | 1.57e-01 | 0.1131 |
11040 | PIM2 | P10T-E | Human | Esophagus | ESCC | 1.09e-10 | 1.51e-01 | 0.116 |
11040 | PIM2 | P11T-E | Human | Esophagus | ESCC | 9.53e-12 | 4.71e-01 | 0.1426 |
11040 | PIM2 | P12T-E | Human | Esophagus | ESCC | 3.22e-13 | 2.36e-01 | 0.1122 |
11040 | PIM2 | P15T-E | Human | Esophagus | ESCC | 7.78e-15 | 2.84e-01 | 0.1149 |
11040 | PIM2 | P16T-E | Human | Esophagus | ESCC | 2.16e-17 | 3.18e-01 | 0.1153 |
11040 | PIM2 | P17T-E | Human | Esophagus | ESCC | 5.73e-03 | 1.91e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003164727 | Esophagus | HGIN | regulation of protein stability | 96/2587 | 298/18723 | 2.21e-16 | 5.76e-14 | 96 |
GO:000989626 | Esophagus | HGIN | positive regulation of catabolic process | 126/2587 | 492/18723 | 1.46e-12 | 2.09e-10 | 126 |
GO:005082127 | Esophagus | HGIN | protein stabilization | 64/2587 | 191/18723 | 3.11e-12 | 4.24e-10 | 64 |
GO:003133126 | Esophagus | HGIN | positive regulation of cellular catabolic process | 112/2587 | 427/18723 | 5.15e-12 | 6.72e-10 | 112 |
GO:001050616 | Esophagus | HGIN | regulation of autophagy | 84/2587 | 317/18723 | 1.39e-09 | 1.08e-07 | 84 |
GO:004312220 | Esophagus | HGIN | regulation of I-kappaB kinase/NF-kappaB signaling | 63/2587 | 249/18723 | 8.91e-07 | 3.61e-05 | 63 |
GO:000724918 | Esophagus | HGIN | I-kappaB kinase/NF-kappaB signaling | 67/2587 | 281/18723 | 3.84e-06 | 1.29e-04 | 67 |
GO:004312317 | Esophagus | HGIN | positive regulation of I-kappaB kinase/NF-kappaB signaling | 49/2587 | 186/18723 | 4.22e-06 | 1.40e-04 | 49 |
GO:000734610 | Esophagus | HGIN | regulation of mitotic cell cycle | 98/2587 | 457/18723 | 4.39e-06 | 1.42e-04 | 98 |
GO:00447729 | Esophagus | HGIN | mitotic cell cycle phase transition | 89/2587 | 424/18723 | 2.80e-05 | 7.21e-04 | 89 |
GO:00000827 | Esophagus | HGIN | G1/S transition of mitotic cell cycle | 48/2587 | 214/18723 | 3.97e-04 | 6.07e-03 | 48 |
GO:00448437 | Esophagus | HGIN | cell cycle G1/S phase transition | 52/2587 | 241/18723 | 6.19e-04 | 8.58e-03 | 52 |
GO:000961517 | Esophagus | HGIN | response to virus | 69/2587 | 367/18723 | 4.39e-03 | 3.86e-02 | 69 |
GO:00105088 | Esophagus | HGIN | positive regulation of autophagy | 28/2587 | 124/18723 | 5.34e-03 | 4.39e-02 | 28 |
GO:0031647111 | Esophagus | ESCC | regulation of protein stability | 223/8552 | 298/18723 | 5.76e-25 | 1.52e-22 | 223 |
GO:0009896111 | Esophagus | ESCC | positive regulation of catabolic process | 332/8552 | 492/18723 | 4.36e-23 | 9.22e-21 | 332 |
GO:0031331111 | Esophagus | ESCC | positive regulation of cellular catabolic process | 292/8552 | 427/18723 | 8.67e-22 | 1.53e-19 | 292 |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:001050617 | Esophagus | ESCC | regulation of autophagy | 220/8552 | 317/18723 | 6.72e-18 | 6.36e-16 | 220 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa052215 | Esophagus | ESCC | Acute myeloid leukemia | 49/4205 | 67/8465 | 7.43e-05 | 3.07e-04 | 1.57e-04 | 49 |
hsa0522113 | Esophagus | ESCC | Acute myeloid leukemia | 49/4205 | 67/8465 | 7.43e-05 | 3.07e-04 | 1.57e-04 | 49 |
hsa052214 | Oral cavity | OSCC | Acute myeloid leukemia | 42/3704 | 67/8465 | 1.34e-03 | 3.75e-03 | 1.91e-03 | 42 |
hsa0522112 | Oral cavity | OSCC | Acute myeloid leukemia | 42/3704 | 67/8465 | 1.34e-03 | 3.75e-03 | 1.91e-03 | 42 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PIM2 | SNV | Missense_Mutation | novel | c.729N>T | p.Glu243Asp | p.E243D | Q9P1W9 | protein_coding | tolerated(0.35) | benign(0.007) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PIM2 | SNV | Missense_Mutation | novel | c.554N>A | p.Ser185Tyr | p.S185Y | Q9P1W9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PIM2 | SNV | Missense_Mutation | novel | c.876N>G | p.Asp292Glu | p.D292E | Q9P1W9 | protein_coding | tolerated(0.37) | benign(0) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PIM2 | SNV | Missense_Mutation | novel | c.200N>A | p.Arg67His | p.R67H | Q9P1W9 | protein_coding | deleterious(0.02) | benign(0.231) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PIM2 | SNV | Missense_Mutation | novel | c.152N>A | p.Arg51His | p.R51H | Q9P1W9 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PIM2 | SNV | Missense_Mutation | novel | c.733N>A | p.Leu245Met | p.L245M | Q9P1W9 | protein_coding | tolerated(0.09) | possibly_damaging(0.564) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
PIM2 | deletion | In_Frame_Del | novel | c.32_40delCGCCCCCCG | p.Ala11_Pro13del | p.A11_P13del | Q9P1W9 | protein_coding | TCGA-D1-A1NY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | ||
PIM2 | SNV | Missense_Mutation | c.562N>G | p.Leu188Val | p.L188V | Q9P1W9 | protein_coding | tolerated(0.16) | benign(0.013) | TCGA-44-7670-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
PIM2 | SNV | Missense_Mutation | c.22N>T | p.Gly8Trp | p.G8W | Q9P1W9 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.817) | TCGA-49-AARE-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
PIM2 | SNV | Missense_Mutation | c.532N>T | p.Ala178Ser | p.A178S | Q9P1W9 | protein_coding | deleterious(0) | benign(0.025) | TCGA-55-6971-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
11040 | PIM2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 178101947 | RUBOXISTAURIN | |
11040 | PIM2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | BAY-613606 | CHEMBL541400 | ||
11040 | PIM2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL3545194 | LGH-447 | |
11040 | PIM2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 381118905 | ||
11040 | PIM2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL3545423 | AZD-1208 | |
11040 | PIM2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 404859073 | ||
11040 | PIM2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 223366031 | ||
11040 | PIM2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 354702263 | ||
11040 | PIM2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL1952329 | SGI-1776 | |
11040 | PIM2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 252827442 | SGI-1776 |
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