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Gene: PHIP |
Gene summary for PHIP |
Gene summary. |
Gene information | Species | Human | Gene symbol | PHIP | Gene ID | 55023 |
Gene name | pleckstrin homology domain interacting protein | |
Gene Alias | BRWD2 | |
Cytomap | 6q14.1 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | Q8WWQ0 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55023 | PHIP | CA_HPV_1 | Human | Cervix | CC | 1.96e-05 | -8.89e-02 | 0.0264 |
55023 | PHIP | CCI_1 | Human | Cervix | CC | 5.91e-03 | 6.57e-01 | 0.528 |
55023 | PHIP | CCI_2 | Human | Cervix | CC | 4.54e-09 | 6.65e-01 | 0.5249 |
55023 | PHIP | CCI_3 | Human | Cervix | CC | 8.57e-07 | 9.79e-01 | 0.516 |
55023 | PHIP | L1 | Human | Cervix | CC | 1.75e-04 | -1.30e-01 | 0.0802 |
55023 | PHIP | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.25e-18 | -7.22e-01 | 0.0155 |
55023 | PHIP | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.73e-08 | -7.27e-01 | -0.1808 |
55023 | PHIP | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.29e-03 | -8.68e-01 | 0.0216 |
55023 | PHIP | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.05e-04 | -6.48e-01 | -0.1207 |
55023 | PHIP | HTA11_696_2000001011 | Human | Colorectum | AD | 5.92e-22 | -6.24e-01 | -0.1464 |
55023 | PHIP | HTA11_866_2000001011 | Human | Colorectum | AD | 5.20e-07 | -4.56e-01 | -0.1001 |
55023 | PHIP | HTA11_7862_2000001011 | Human | Colorectum | AD | 9.88e-06 | -8.07e-01 | -0.0179 |
55023 | PHIP | HTA11_866_3004761011 | Human | Colorectum | AD | 3.95e-12 | -6.75e-01 | 0.096 |
55023 | PHIP | HTA11_9408_2000001011 | Human | Colorectum | AD | 8.33e-03 | -9.26e-01 | 0.0451 |
55023 | PHIP | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.42e-02 | -6.41e-01 | 0.0528 |
55023 | PHIP | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.24e-06 | -6.65e-01 | 0.0338 |
55023 | PHIP | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.14e-18 | -5.79e-01 | 0.0674 |
55023 | PHIP | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.82e-06 | -5.49e-01 | 0.0588 |
55023 | PHIP | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.26e-13 | -5.31e-01 | 0.294 |
55023 | PHIP | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.25e-05 | -3.75e-01 | 0.3859 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200123310 | Cervix | CC | regulation of apoptotic signaling pathway | 96/2311 | 356/18723 | 4.08e-14 | 3.05e-11 | 96 |
GO:002260410 | Cervix | CC | regulation of cell morphogenesis | 84/2311 | 309/18723 | 1.00e-12 | 4.29e-10 | 84 |
GO:200123410 | Cervix | CC | negative regulation of apoptotic signaling pathway | 56/2311 | 224/18723 | 1.39e-07 | 6.70e-06 | 56 |
GO:009719110 | Cervix | CC | extrinsic apoptotic signaling pathway | 52/2311 | 219/18723 | 2.06e-06 | 6.34e-05 | 52 |
GO:00457876 | Cervix | CC | positive regulation of cell cycle | 66/2311 | 313/18723 | 7.78e-06 | 1.81e-04 | 66 |
GO:00073466 | Cervix | CC | regulation of mitotic cell cycle | 88/2311 | 457/18723 | 1.26e-05 | 2.60e-04 | 88 |
GO:00083608 | Cervix | CC | regulation of cell shape | 38/2311 | 154/18723 | 1.86e-05 | 3.46e-04 | 38 |
GO:19016538 | Cervix | CC | cellular response to peptide | 72/2311 | 359/18723 | 1.89e-05 | 3.48e-04 | 72 |
GO:200123610 | Cervix | CC | regulation of extrinsic apoptotic signaling pathway | 37/2311 | 151/18723 | 2.80e-05 | 4.65e-04 | 37 |
GO:00900685 | Cervix | CC | positive regulation of cell cycle process | 50/2311 | 236/18723 | 8.25e-05 | 1.11e-03 | 50 |
GO:00434349 | Cervix | CC | response to peptide hormone | 77/2311 | 414/18723 | 1.40e-04 | 1.70e-03 | 77 |
GO:00713757 | Cervix | CC | cellular response to peptide hormone stimulus | 57/2311 | 290/18723 | 2.32e-04 | 2.59e-03 | 57 |
GO:00328698 | Cervix | CC | cellular response to insulin stimulus | 42/2311 | 203/18723 | 4.95e-04 | 4.83e-03 | 42 |
GO:00328688 | Cervix | CC | response to insulin | 50/2311 | 264/18723 | 1.28e-03 | 1.02e-02 | 50 |
GO:200123710 | Cervix | CC | negative regulation of extrinsic apoptotic signaling pathway | 23/2311 | 97/18723 | 1.39e-03 | 1.10e-02 | 23 |
GO:00082865 | Cervix | CC | insulin receptor signaling pathway | 25/2311 | 116/18723 | 3.59e-03 | 2.30e-02 | 25 |
GO:01400143 | Cervix | CC | mitotic nuclear division | 50/2311 | 287/18723 | 7.27e-03 | 3.91e-02 | 50 |
GO:00482851 | Cervix | CC | organelle fission | 78/2311 | 488/18723 | 9.70e-03 | 4.79e-02 | 78 |
GO:0022604 | Colorectum | AD | regulation of cell morphogenesis | 109/3918 | 309/18723 | 3.08e-09 | 2.07e-07 | 109 |
GO:2001233 | Colorectum | AD | regulation of apoptotic signaling pathway | 119/3918 | 356/18723 | 2.14e-08 | 1.21e-06 | 119 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHIP | SNV | Missense_Mutation | c.4448G>A | p.Arg1483Gln | p.R1483Q | Q8WWQ0 | protein_coding | tolerated(0.45) | probably_damaging(0.921) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
PHIP | SNV | Missense_Mutation | c.3148N>A | p.Asp1050Asn | p.D1050N | Q8WWQ0 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PHIP | SNV | Missense_Mutation | c.764N>A | p.Arg255Gln | p.R255Q | Q8WWQ0 | protein_coding | tolerated(0.46) | benign(0.033) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PHIP | SNV | Missense_Mutation | c.4409N>T | p.Lys1470Ile | p.K1470I | Q8WWQ0 | protein_coding | deleterious(0.02) | benign(0.265) | TCGA-AA-3697-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PHIP | SNV | Missense_Mutation | c.4306N>G | p.Thr1436Ala | p.T1436A | Q8WWQ0 | protein_coding | tolerated(0.26) | benign(0.007) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PHIP | SNV | Missense_Mutation | novel | c.5327N>T | p.Ala1776Val | p.A1776V | Q8WWQ0 | protein_coding | tolerated_low_confidence(0.35) | benign(0.057) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PHIP | SNV | Missense_Mutation | c.3838T>G | p.Leu1280Val | p.L1280V | Q8WWQ0 | protein_coding | tolerated(0.51) | benign(0.011) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PHIP | SNV | Missense_Mutation | c.2742A>C | p.Lys914Asn | p.K914N | Q8WWQ0 | protein_coding | tolerated(0.12) | possibly_damaging(0.879) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PHIP | SNV | Missense_Mutation | c.1036C>T | p.Arg346Trp | p.R346W | Q8WWQ0 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PHIP | SNV | Missense_Mutation | c.5131N>T | p.Arg1711Cys | p.R1711C | Q8WWQ0 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.799) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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