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Gene: PEG3 |
Gene summary for PEG3 |
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Gene information | Species | Human | Gene symbol | PEG3 | Gene ID | 5178 |
Gene name | paternally expressed 3 | |
Gene Alias | PW1 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9GZU2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5178 | PEG3 | GSM4909281 | Human | Breast | IDC | 1.58e-28 | 5.45e-01 | 0.21 |
5178 | PEG3 | GSM4909298 | Human | Breast | IDC | 4.14e-61 | 8.98e-01 | 0.1551 |
5178 | PEG3 | GSM4909304 | Human | Breast | IDC | 5.34e-07 | 2.18e-01 | 0.1636 |
5178 | PEG3 | HCC1_Meng | Human | Liver | HCC | 8.95e-10 | 4.36e-02 | 0.0246 |
5178 | PEG3 | HCC2 | Human | Liver | HCC | 1.25e-22 | 3.74e+00 | 0.5341 |
5178 | PEG3 | S014 | Human | Liver | HCC | 2.68e-34 | 1.10e+00 | 0.2254 |
5178 | PEG3 | S015 | Human | Liver | HCC | 3.41e-32 | 1.14e+00 | 0.2375 |
5178 | PEG3 | S016 | Human | Liver | HCC | 4.77e-32 | 1.21e+00 | 0.2243 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
PEG3 | PERI | Cervix | HSIL_HPV | AC006115.2,HES6,SERTM1, etc. | 3.67e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PEG3 | insertion | Nonsense_Mutation | novel | c.1312_1313insAGAGACAGGATCTCAATATGGTGCCCAGGGCTC | p.Ser438delinsTer | p.S438delins* | Q9GZU2 | protein_coding | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
PEG3 | insertion | In_Frame_Ins | novel | c.3803_3804insAGCAGCCCAGGAAGTTGAAGCCAATGTCCATGTTCCACAAGT | p.Ala1268_Leu1269insAlaAlaGlnGluValGluAlaAsnValHisValProGlnVal | p.A1268_L1269insAAQEVEANVHVPQV | Q9GZU2 | protein_coding | TCGA-A8-A09T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | ||
PEG3 | insertion | Nonsense_Mutation | novel | c.1520_1521insAAACTCAT | p.Cys507Ter | p.C507* | Q9GZU2 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PEG3 | insertion | Frame_Shift_Ins | novel | c.1519_1520insTTTCTCTTTACCATACATTTTCT | p.Cys507PhefsTer80 | p.C507Ffs*80 | Q9GZU2 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PEG3 | insertion | Nonsense_Mutation | novel | c.3013_3014insAGACT | p.Ser1005Ter | p.S1005* | Q9GZU2 | protein_coding | TCGA-AR-A0U2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | PD | ||
PEG3 | insertion | Frame_Shift_Ins | novel | c.3120_3121insT | p.Ala1041CysfsTer14 | p.A1041Cfs*14 | Q9GZU2 | protein_coding | TCGA-BH-A1F8-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
PEG3 | deletion | Frame_Shift_Del | novel | c.2198delN | p.Lys733ArgfsTer5 | p.K733Rfs*5 | Q9GZU2 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
PEG3 | SNV | Missense_Mutation | rs369854592 | c.2888N>A | p.Arg963His | p.R963H | Q9GZU2 | protein_coding | tolerated(0.7) | benign(0.001) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PEG3 | SNV | Missense_Mutation | novel | c.940N>G | p.Ile314Val | p.I314V | Q9GZU2 | protein_coding | deleterious(0.01) | benign(0.34) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PEG3 | SNV | Missense_Mutation | c.655N>C | p.Glu219Gln | p.E219Q | Q9GZU2 | protein_coding | deleterious(0.05) | possibly_damaging(0.795) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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