![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PDGFRL |
Gene summary for PDGFRL |
![]() |
Gene information | Species | Human | Gene symbol | PDGFRL | Gene ID | 5157 |
Gene name | platelet derived growth factor receptor like | |
Gene Alias | PDGRL | |
Cytomap | 8p22 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q15198 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5157 | PDGFRL | P2T-E | Human | Esophagus | ESCC | 5.23e-16 | 2.98e-01 | 0.1177 |
5157 | PDGFRL | P4T-E | Human | Esophagus | ESCC | 1.44e-06 | 1.49e-01 | 0.1323 |
5157 | PDGFRL | P8T-E | Human | Esophagus | ESCC | 8.85e-07 | 1.55e-01 | 0.0889 |
5157 | PDGFRL | P9T-E | Human | Esophagus | ESCC | 5.12e-06 | 5.82e-01 | 0.1131 |
5157 | PDGFRL | P16T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.29e-01 | 0.1153 |
5157 | PDGFRL | P23T-E | Human | Esophagus | ESCC | 6.46e-03 | 8.40e-02 | 0.108 |
5157 | PDGFRL | P32T-E | Human | Esophagus | ESCC | 8.51e-08 | 1.65e-01 | 0.1666 |
5157 | PDGFRL | P44T-E | Human | Esophagus | ESCC | 2.69e-05 | 6.35e-01 | 0.1096 |
5157 | PDGFRL | P47T-E | Human | Esophagus | ESCC | 1.55e-03 | 2.80e-01 | 0.1067 |
5157 | PDGFRL | P52T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.13e-01 | 0.1555 |
5157 | PDGFRL | P56T-E | Human | Esophagus | ESCC | 4.20e-02 | 3.80e-01 | 0.1613 |
5157 | PDGFRL | P61T-E | Human | Esophagus | ESCC | 6.15e-06 | 9.82e-02 | 0.099 |
5157 | PDGFRL | P76T-E | Human | Esophagus | ESCC | 1.66e-05 | 1.59e-01 | 0.1207 |
5157 | PDGFRL | P130T-E | Human | Esophagus | ESCC | 2.90e-04 | 1.81e-01 | 0.1676 |
5157 | PDGFRL | male-WTA | Human | Thyroid | PTC | 1.06e-26 | 1.70e-01 | 0.1037 |
5157 | PDGFRL | PTC01 | Human | Thyroid | PTC | 1.93e-08 | 2.73e-01 | 0.1899 |
5157 | PDGFRL | PTC04 | Human | Thyroid | PTC | 2.30e-08 | 1.96e-01 | 0.1927 |
5157 | PDGFRL | PTC05 | Human | Thyroid | PTC | 1.27e-15 | 8.03e-01 | 0.2065 |
5157 | PDGFRL | PTC06 | Human | Thyroid | PTC | 1.43e-22 | 8.03e-01 | 0.2057 |
5157 | PDGFRL | PTC07 | Human | Thyroid | PTC | 9.16e-36 | 7.76e-01 | 0.2044 |
Page: 1 2 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00480087 | Esophagus | ESCC | platelet-derived growth factor receptor signaling pathway | 42/8552 | 56/18723 | 7.62e-06 | 7.54e-05 | 42 |
GO:00480089 | Thyroid | PTC | platelet-derived growth factor receptor signaling pathway | 34/5968 | 56/18723 | 8.20e-06 | 9.42e-05 | 34 |
GO:00357912 | Thyroid | PTC | platelet-derived growth factor receptor-beta signaling pathway | 9/5968 | 14/18723 | 1.27e-02 | 4.92e-02 | 9 |
GO:004800815 | Thyroid | ATC | platelet-derived growth factor receptor signaling pathway | 36/6293 | 56/18723 | 2.57e-06 | 3.00e-05 | 36 |
GO:00357911 | Thyroid | ATC | platelet-derived growth factor receptor-beta signaling pathway | 10/6293 | 14/18723 | 4.31e-03 | 1.80e-02 | 10 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDGFRL | SNV | Missense_Mutation | novel | c.815N>T | p.Pro272Leu | p.P272L | Q15198 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-49-AAR4-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxol | PD |
PDGFRL | SNV | Missense_Mutation | novel | c.328G>T | p.Asp110Tyr | p.D110Y | Q15198 | protein_coding | deleterious(0) | possibly_damaging(0.863) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PDGFRL | SNV | Missense_Mutation | c.717N>C | p.Glu239Asp | p.E239D | Q15198 | protein_coding | tolerated(1) | benign(0) | TCGA-62-A471-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | |
PDGFRL | SNV | Missense_Mutation | c.635N>T | p.Pro212Leu | p.P212L | Q15198 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PDGFRL | SNV | Missense_Mutation | novel | c.410A>G | p.Asp137Gly | p.D137G | Q15198 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
PDGFRL | SNV | Missense_Mutation | rs750440858 | c.448G>T | p.Gly150Cys | p.G150C | Q15198 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-85-8071-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PDGFRL | SNV | Missense_Mutation | novel | c.384G>T | p.Leu128Phe | p.L128F | Q15198 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-CV-6433-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PDGFRL | SNV | Missense_Mutation | novel | c.589C>T | p.Arg197Trp | p.R197W | Q15198 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-CV-6961-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
PDGFRL | SNV | Missense_Mutation | novel | c.572N>T | p.Gln191Leu | p.Q191L | Q15198 | protein_coding | deleterious(0) | benign(0.142) | TCGA-CV-A45V-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PDGFRL | insertion | Frame_Shift_Ins | novel | c.304_305insTAGGGAGATGTTTGGCAAC | p.Gly102ValfsTer18 | p.G102Vfs*18 | Q15198 | protein_coding | TCGA-KK-A7B3-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | PD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |