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Gene: PDE6A |
Gene summary for PDE6A |
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Gene information | Species | Human | Gene symbol | PDE6A | Gene ID | 5145 |
Gene name | phosphodiesterase 6A | |
Gene Alias | CGPR-A | |
Cytomap | 5q32 | |
Gene Type | protein-coding | GO ID | GO:0001654 | UniProtAcc | P16499 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5145 | PDE6A | HCC1 | Human | Liver | HCC | 3.24e-18 | 1.70e+00 | 0.5336 |
5145 | PDE6A | HCC2 | Human | Liver | HCC | 3.03e-30 | 2.22e+00 | 0.5341 |
5145 | PDE6A | HCC5 | Human | Liver | HCC | 1.06e-31 | 2.07e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDE6A | SNV | Missense_Mutation | novel | c.1528G>C | p.Asp510His | p.D510H | P16499 | protein_coding | deleterious(0) | benign(0.12) | TCGA-AA-A01K-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR |
PDE6A | SNV | Missense_Mutation | c.1049N>C | p.Val350Ala | p.V350A | P16499 | protein_coding | deleterious(0.04) | possibly_damaging(0.803) | TCGA-AA-A02O-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PDE6A | SNV | Missense_Mutation | c.379N>G | p.Met127Val | p.M127V | P16499 | protein_coding | tolerated(0.54) | benign(0) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PDE6A | SNV | Missense_Mutation | c.1862N>A | p.Leu621His | p.L621H | P16499 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
PDE6A | SNV | Missense_Mutation | c.829N>A | p.Val277Met | p.V277M | P16499 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PDE6A | SNV | Missense_Mutation | rs770823436 | c.2432N>T | p.Ala811Val | p.A811V | P16499 | protein_coding | tolerated(0.08) | benign(0.296) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PDE6A | SNV | Missense_Mutation | c.210N>T | p.Glu70Asp | p.E70D | P16499 | protein_coding | tolerated(0.24) | benign(0.02) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PDE6A | SNV | Missense_Mutation | novel | c.934G>A | p.Glu312Lys | p.E312K | P16499 | protein_coding | tolerated(0.06) | probably_damaging(0.986) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PDE6A | SNV | Missense_Mutation | c.667N>G | p.Lys223Glu | p.K223E | P16499 | protein_coding | deleterious(0.02) | benign(0.434) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PDE6A | insertion | Frame_Shift_Ins | novel | c.518_519insA | p.Thr174AspfsTer24 | p.T174Dfs*24 | P16499 | protein_coding | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5145 | PDE6A | DRUGGABLE GENOME, ENZYME | inhibitor | 252827469 | ||
5145 | PDE6A | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL628 | PENTOXIFYLLINE | |
5145 | PDE6A | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL932 | DIPYRIDAMOLE |
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