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Gene: P3H3 |
Gene summary for P3H3 |
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Gene information | Species | Human | Gene symbol | P3H3 | Gene ID | 10536 |
Gene name | prolyl 3-hydroxylase 3 | |
Gene Alias | GRCB | |
Cytomap | 12p13.31 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8IVL6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10536 | P3H3 | male-WTA | Human | Thyroid | PTC | 3.40e-05 | 1.46e-01 | 0.1037 |
10536 | P3H3 | PTC01 | Human | Thyroid | PTC | 3.83e-07 | 1.89e-01 | 0.1899 |
10536 | P3H3 | PTC04 | Human | Thyroid | PTC | 6.92e-05 | 1.26e-01 | 0.1927 |
10536 | P3H3 | PTC05 | Human | Thyroid | PTC | 1.26e-11 | 3.43e-01 | 0.2065 |
10536 | P3H3 | PTC06 | Human | Thyroid | PTC | 1.23e-15 | 3.33e-01 | 0.2057 |
10536 | P3H3 | PTC07 | Human | Thyroid | PTC | 6.64e-14 | 2.97e-01 | 0.2044 |
10536 | P3H3 | ATC09 | Human | Thyroid | ATC | 5.36e-33 | 1.07e+00 | 0.2871 |
10536 | P3H3 | ATC11 | Human | Thyroid | ATC | 9.94e-09 | 5.90e-01 | 0.3386 |
10536 | P3H3 | ATC12 | Human | Thyroid | ATC | 5.61e-58 | 1.21e+00 | 0.34 |
10536 | P3H3 | ATC13 | Human | Thyroid | ATC | 4.63e-28 | 5.48e-01 | 0.34 |
10536 | P3H3 | ATC1 | Human | Thyroid | ATC | 2.97e-33 | 1.12e+00 | 0.2878 |
10536 | P3H3 | ATC2 | Human | Thyroid | ATC | 8.57e-18 | 1.16e+00 | 0.34 |
10536 | P3H3 | ATC3 | Human | Thyroid | ATC | 2.85e-21 | 7.78e-01 | 0.338 |
10536 | P3H3 | ATC4 | Human | Thyroid | ATC | 5.44e-75 | 1.39e+00 | 0.34 |
10536 | P3H3 | ATC5 | Human | Thyroid | ATC | 4.07e-31 | 6.20e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00182059 | Thyroid | PTC | peptidyl-lysine modification | 188/5968 | 376/18723 | 1.34e-13 | 7.09e-12 | 188 |
GO:001820817 | Thyroid | PTC | peptidyl-proline modification | 42/5968 | 58/18723 | 2.71e-10 | 8.91e-09 | 42 |
GO:00181265 | Thyroid | PTC | protein hydroxylation | 17/5968 | 27/18723 | 8.67e-04 | 5.30e-03 | 17 |
GO:00195116 | Thyroid | PTC | peptidyl-proline hydroxylation | 11/5968 | 15/18723 | 1.19e-03 | 6.84e-03 | 11 |
GO:001820516 | Thyroid | ATC | peptidyl-lysine modification | 193/6293 | 376/18723 | 6.92e-13 | 3.06e-11 | 193 |
GO:001820818 | Thyroid | ATC | peptidyl-proline modification | 42/6293 | 58/18723 | 1.70e-09 | 4.21e-08 | 42 |
GO:00329633 | Thyroid | ATC | collagen metabolic process | 52/6293 | 104/18723 | 3.94e-04 | 2.38e-03 | 52 |
GO:001812612 | Thyroid | ATC | protein hydroxylation | 17/6293 | 27/18723 | 1.70e-03 | 8.47e-03 | 17 |
GO:001951111 | Thyroid | ATC | peptidyl-proline hydroxylation | 11/6293 | 15/18723 | 1.94e-03 | 9.41e-03 | 11 |
GO:00329641 | Thyroid | ATC | collagen biosynthetic process | 27/6293 | 51/18723 | 3.41e-03 | 1.52e-02 | 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
P3H3 | deletion | Frame_Shift_Del | c.1435delN | p.Val480CysfsTer59 | p.V480Cfs*59 | Q8IVL6 | protein_coding | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
P3H3 | SNV | Missense_Mutation | novel | c.2081C>T | p.Ser694Leu | p.S694L | Q8IVL6 | protein_coding | tolerated(0.32) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
P3H3 | SNV | Missense_Mutation | novel | c.2125G>T | p.Asp709Tyr | p.D709Y | Q8IVL6 | protein_coding | deleterious(0.01) | benign(0.261) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
P3H3 | SNV | Missense_Mutation | rs368711010 | c.1993N>T | p.Arg665Trp | p.R665W | Q8IVL6 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
P3H3 | SNV | Missense_Mutation | rs373813652 | c.1753G>A | p.Ala585Thr | p.A585T | Q8IVL6 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
P3H3 | SNV | Missense_Mutation | rs782475839 | c.2198N>A | p.Arg733Gln | p.R733Q | Q8IVL6 | protein_coding | deleterious(0.01) | probably_damaging(0.982) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
P3H3 | SNV | Missense_Mutation | rs368711010 | c.1993C>T | p.Arg665Trp | p.R665W | Q8IVL6 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AX-A2HA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
P3H3 | SNV | Missense_Mutation | rs782693652 | c.1531G>A | p.Glu511Lys | p.E511K | Q8IVL6 | protein_coding | deleterious(0.04) | possibly_damaging(0.742) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
P3H3 | SNV | Missense_Mutation | rs782171760 | c.1396C>T | p.Arg466Trp | p.R466W | Q8IVL6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
P3H3 | SNV | Missense_Mutation | c.560N>G | p.His187Arg | p.H187R | Q8IVL6 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10536 | P3H3 | DRUGGABLE GENOME | sertraline | SERTRALINE | 30324302 |
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