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Gene: OXA1L |
Gene summary for OXA1L |
Gene summary. |
Gene information | Species | Human | Gene symbol | OXA1L | Gene ID | 5018 |
Gene name | OXA1L mitochondrial inner membrane protein | |
Gene Alias | OXA1 | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | J3KNA0 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5018 | OXA1L | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.34e-12 | 4.04e-01 | 0.0155 |
5018 | OXA1L | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.58e-02 | 3.20e-01 | -0.1808 |
5018 | OXA1L | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.97e-02 | 3.82e-01 | -0.0811 |
5018 | OXA1L | HTA11_78_2000001011 | Human | Colorectum | AD | 8.51e-06 | 3.92e-01 | -0.1088 |
5018 | OXA1L | HTA11_347_2000001011 | Human | Colorectum | AD | 4.36e-19 | 5.99e-01 | -0.1954 |
5018 | OXA1L | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.84e-03 | 3.85e-01 | -0.1207 |
5018 | OXA1L | HTA11_83_2000001011 | Human | Colorectum | SER | 4.16e-08 | 5.41e-01 | -0.1526 |
5018 | OXA1L | HTA11_696_2000001011 | Human | Colorectum | AD | 2.06e-12 | 3.94e-01 | -0.1464 |
5018 | OXA1L | HTA11_866_2000001011 | Human | Colorectum | AD | 1.18e-05 | 3.21e-01 | -0.1001 |
5018 | OXA1L | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.00e-17 | 7.49e-01 | -0.059 |
5018 | OXA1L | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.05e-05 | 7.01e-01 | -0.1462 |
5018 | OXA1L | HTA11_546_2000001011 | Human | Colorectum | AD | 1.10e-03 | 3.95e-01 | -0.0842 |
5018 | OXA1L | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.71e-04 | 5.05e-01 | -0.0179 |
5018 | OXA1L | HTA11_866_3004761011 | Human | Colorectum | AD | 3.88e-18 | 6.29e-01 | 0.096 |
5018 | OXA1L | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.70e-03 | 6.22e-01 | 0.0446 |
5018 | OXA1L | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.03e-04 | 6.55e-01 | 0.0528 |
5018 | OXA1L | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.99e-06 | 6.81e-01 | 0.0131 |
5018 | OXA1L | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.19e-08 | 8.08e-01 | 0.0171 |
5018 | OXA1L | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.53e-05 | 3.57e-01 | 0.0338 |
5018 | OXA1L | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.87e-19 | 5.37e-01 | 0.0674 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
GO:0009060 | Colorectum | AD | aerobic respiration | 108/3918 | 189/18723 | 9.14e-28 | 1.43e-24 | 108 |
GO:0045333 | Colorectum | AD | cellular respiration | 119/3918 | 230/18723 | 3.21e-25 | 4.02e-22 | 119 |
GO:0015980 | Colorectum | AD | energy derivation by oxidation of organic compounds | 143/3918 | 318/18723 | 2.78e-22 | 2.49e-19 | 143 |
GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:0010257 | Colorectum | AD | NADH dehydrogenase complex assembly | 34/3918 | 57/18723 | 2.15e-10 | 1.89e-08 | 34 |
GO:0032981 | Colorectum | AD | mitochondrial respiratory chain complex I assembly | 34/3918 | 57/18723 | 2.15e-10 | 1.89e-08 | 34 |
GO:0033108 | Colorectum | AD | mitochondrial respiratory chain complex assembly | 46/3918 | 93/18723 | 8.95e-10 | 6.91e-08 | 46 |
GO:0070585 | Colorectum | AD | protein localization to mitochondrion | 51/3918 | 125/18723 | 3.40e-07 | 1.33e-05 | 51 |
GO:0007006 | Colorectum | AD | mitochondrial membrane organization | 48/3918 | 116/18723 | 4.53e-07 | 1.72e-05 | 48 |
GO:0072655 | Colorectum | AD | establishment of protein localization to mitochondrion | 47/3918 | 120/18723 | 3.76e-06 | 1.04e-04 | 47 |
GO:0090151 | Colorectum | AD | establishment of protein localization to mitochondrial membrane | 15/3918 | 30/18723 | 3.85e-04 | 4.39e-03 | 15 |
GO:0051205 | Colorectum | AD | protein insertion into membrane | 23/3918 | 57/18723 | 6.62e-04 | 6.80e-03 | 23 |
GO:00090601 | Colorectum | SER | aerobic respiration | 96/2897 | 189/18723 | 5.53e-30 | 1.70e-26 | 96 |
GO:00453331 | Colorectum | SER | cellular respiration | 103/2897 | 230/18723 | 2.35e-26 | 3.61e-23 | 103 |
GO:00060911 | Colorectum | SER | generation of precursor metabolites and energy | 168/2897 | 490/18723 | 1.39e-25 | 1.70e-22 | 168 |
GO:00159801 | Colorectum | SER | energy derivation by oxidation of organic compounds | 119/2897 | 318/18723 | 5.28e-22 | 4.62e-19 | 119 |
GO:00068391 | Colorectum | SER | mitochondrial transport | 87/2897 | 254/18723 | 7.91e-14 | 3.03e-11 | 87 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa03060 | Colorectum | AD | Protein export | 14/2092 | 23/8465 | 2.43e-04 | 1.90e-03 | 1.21e-03 | 14 |
hsa030601 | Colorectum | AD | Protein export | 14/2092 | 23/8465 | 2.43e-04 | 1.90e-03 | 1.21e-03 | 14 |
hsa030602 | Colorectum | MSS | Protein export | 15/1875 | 23/8465 | 1.13e-05 | 1.26e-04 | 7.71e-05 | 15 |
hsa030603 | Colorectum | MSS | Protein export | 15/1875 | 23/8465 | 1.13e-05 | 1.26e-04 | 7.71e-05 | 15 |
hsa030604 | Colorectum | MSI-H | Protein export | 11/797 | 23/8465 | 2.26e-06 | 3.65e-05 | 3.06e-05 | 11 |
hsa030605 | Colorectum | MSI-H | Protein export | 11/797 | 23/8465 | 2.26e-06 | 3.65e-05 | 3.06e-05 | 11 |
hsa0306020 | Esophagus | HGIN | Protein export | 13/1383 | 23/8465 | 1.27e-05 | 1.80e-04 | 1.43e-04 | 13 |
hsa03060110 | Esophagus | HGIN | Protein export | 13/1383 | 23/8465 | 1.27e-05 | 1.80e-04 | 1.43e-04 | 13 |
hsa0306026 | Esophagus | ESCC | Protein export | 22/4205 | 23/8465 | 2.43e-06 | 1.43e-05 | 7.32e-06 | 22 |
hsa0306036 | Esophagus | ESCC | Protein export | 22/4205 | 23/8465 | 2.43e-06 | 1.43e-05 | 7.32e-06 | 22 |
hsa030608 | Liver | Cirrhotic | Protein export | 20/2530 | 23/8465 | 2.00e-08 | 3.51e-07 | 2.17e-07 | 20 |
hsa0306011 | Liver | Cirrhotic | Protein export | 20/2530 | 23/8465 | 2.00e-08 | 3.51e-07 | 2.17e-07 | 20 |
hsa0306021 | Liver | HCC | Protein export | 21/4020 | 23/8465 | 1.20e-05 | 8.53e-05 | 4.74e-05 | 21 |
hsa0306031 | Liver | HCC | Protein export | 21/4020 | 23/8465 | 1.20e-05 | 8.53e-05 | 4.74e-05 | 21 |
hsa0306018 | Oral cavity | OSCC | Protein export | 21/3704 | 23/8465 | 2.42e-06 | 1.27e-05 | 6.45e-06 | 21 |
hsa0306019 | Oral cavity | OSCC | Protein export | 21/3704 | 23/8465 | 2.42e-06 | 1.27e-05 | 6.45e-06 | 21 |
hsa0306025 | Oral cavity | LP | Protein export | 21/2418 | 23/8465 | 4.72e-10 | 8.28e-09 | 5.34e-09 | 21 |
hsa0306035 | Oral cavity | LP | Protein export | 21/2418 | 23/8465 | 4.72e-10 | 8.28e-09 | 5.34e-09 | 21 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OXA1L | SNV | Missense_Mutation | novel | c.558N>T | p.Gln186His | p.Q186H | protein_coding | deleterious(0.04) | probably_damaging(0.993) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
OXA1L | SNV | Missense_Mutation | novel | c.273N>T | p.Trp91Cys | p.W91C | protein_coding | deleterious_low_confidence(0.01) | benign(0.042) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
OXA1L | SNV | Missense_Mutation | novel | c.1418N>G | p.Asn473Ser | p.N473S | protein_coding | tolerated(0.84) | benign(0.007) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
OXA1L | SNV | Missense_Mutation | rs769406557 | c.392T>C | p.Phe131Ser | p.F131S | protein_coding | tolerated(0.15) | benign(0.23) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
OXA1L | SNV | Missense_Mutation | novel | c.1124N>C | p.Val375Ala | p.V375A | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD | |
OXA1L | insertion | Frame_Shift_Ins | novel | c.806_807insGGCAG | p.His269GlnfsTer15 | p.H269Qfs*15 | protein_coding | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |||
OXA1L | SNV | Missense_Mutation | c.65N>C | p.Leu22Ser | p.L22S | protein_coding | deleterious_low_confidence(0) | benign(0.015) | TCGA-55-A48X-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
OXA1L | SNV | Missense_Mutation | c.669G>C | p.Gln223His | p.Q223H | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-66-2787-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
OXA1L | SNV | Missense_Mutation | novel | c.209N>T | p.Arg70Leu | p.R70L | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.822) | TCGA-NC-A5HT-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PR | |
OXA1L | SNV | Missense_Mutation | novel | c.79C>G | p.Arg27Gly | p.R27G | protein_coding | tolerated_low_confidence(0.14) | benign(0.186) | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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