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Gene: OTUD7A |
Gene summary for OTUD7A |
Gene summary. |
Gene information | Species | Human | Gene symbol | OTUD7A | Gene ID | 161725 |
Gene name | OTU deubiquitinase 7A | |
Gene Alias | C15orf16 | |
Cytomap | 15q13.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8TE49 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
161725 | OTUD7A | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.25e-22 | -7.15e-01 | 0.0155 |
161725 | OTUD7A | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.23e-03 | -5.12e-01 | -0.1808 |
161725 | OTUD7A | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.50e-07 | -6.38e-01 | -0.0811 |
161725 | OTUD7A | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.57e-02 | -5.13e-01 | -0.1207 |
161725 | OTUD7A | HTA11_696_2000001011 | Human | Colorectum | AD | 6.11e-07 | -3.74e-01 | -0.1464 |
161725 | OTUD7A | HTA11_866_2000001011 | Human | Colorectum | AD | 1.74e-02 | -3.17e-01 | -0.1001 |
161725 | OTUD7A | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.34e-03 | -6.89e-01 | -0.2061 |
161725 | OTUD7A | HTA11_866_3004761011 | Human | Colorectum | AD | 8.20e-13 | -6.18e-01 | 0.096 |
161725 | OTUD7A | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.68e-04 | -5.01e-01 | 0.0338 |
161725 | OTUD7A | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.19e-10 | -4.26e-01 | 0.0674 |
161725 | OTUD7A | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.36e-02 | -4.46e-01 | 0.0588 |
161725 | OTUD7A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.14e-34 | -7.35e-01 | 0.294 |
161725 | OTUD7A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.72e-04 | -5.88e-01 | 0.281 |
161725 | OTUD7A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.95e-19 | -6.23e-01 | 0.3859 |
161725 | OTUD7A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.62e-02 | -2.24e-01 | 0.3005 |
161725 | OTUD7A | F007 | Human | Colorectum | FAP | 8.34e-03 | -3.90e-01 | 0.1176 |
161725 | OTUD7A | A002-C-010 | Human | Colorectum | FAP | 1.63e-07 | -4.02e-01 | 0.242 |
161725 | OTUD7A | A001-C-207 | Human | Colorectum | FAP | 3.73e-05 | -3.53e-01 | 0.1278 |
161725 | OTUD7A | A015-C-203 | Human | Colorectum | FAP | 1.17e-31 | -5.27e-01 | -0.1294 |
161725 | OTUD7A | A015-C-204 | Human | Colorectum | FAP | 3.13e-08 | -4.26e-01 | -0.0228 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043122 | Colorectum | AD | regulation of I-kappaB kinase/NF-kappaB signaling | 76/3918 | 249/18723 | 2.17e-04 | 2.85e-03 | 76 |
GO:0007249 | Colorectum | AD | I-kappaB kinase/NF-kappaB signaling | 82/3918 | 281/18723 | 6.09e-04 | 6.40e-03 | 82 |
GO:00431221 | Colorectum | MSS | regulation of I-kappaB kinase/NF-kappaB signaling | 71/3467 | 249/18723 | 7.12e-05 | 1.21e-03 | 71 |
GO:00072491 | Colorectum | MSS | I-kappaB kinase/NF-kappaB signaling | 77/3467 | 281/18723 | 1.51e-04 | 2.19e-03 | 77 |
GO:0071108 | Colorectum | MSS | protein K48-linked deubiquitination | 13/3467 | 35/18723 | 7.38e-03 | 4.68e-02 | 13 |
GO:00431222 | Colorectum | FAP | regulation of I-kappaB kinase/NF-kappaB signaling | 56/2622 | 249/18723 | 1.82e-04 | 2.69e-03 | 56 |
GO:00072492 | Colorectum | FAP | I-kappaB kinase/NF-kappaB signaling | 58/2622 | 281/18723 | 1.37e-03 | 1.24e-02 | 58 |
GO:00431223 | Colorectum | CRC | regulation of I-kappaB kinase/NF-kappaB signaling | 41/2078 | 249/18723 | 6.39e-03 | 4.64e-02 | 41 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OTUD7A | SNV | Missense_Mutation | c.893C>T | p.Pro298Leu | p.P298L | Q8TE49 | protein_coding | deleterious(0.01) | possibly_damaging(0.76) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
OTUD7A | SNV | Missense_Mutation | rs767158283 | c.1820N>T | p.Pro607Leu | p.P607L | Q8TE49 | protein_coding | tolerated_low_confidence(0.2) | benign(0) | TCGA-D5-5540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
OTUD7A | SNV | Missense_Mutation | rs759665162 | c.1600G>A | p.Gly534Ser | p.G534S | Q8TE49 | protein_coding | tolerated(0.17) | probably_damaging(0.999) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
OTUD7A | SNV | Missense_Mutation | novel | c.882N>A | p.Asn294Lys | p.N294K | Q8TE49 | protein_coding | tolerated(0.12) | probably_damaging(0.965) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
OTUD7A | SNV | Missense_Mutation | c.592N>T | p.Arg198Trp | p.R198W | Q8TE49 | protein_coding | deleterious(0) | possibly_damaging(0.893) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
OTUD7A | SNV | Missense_Mutation | rs758880132 | c.553C>T | p.Arg185Cys | p.R185C | Q8TE49 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
OTUD7A | SNV | Missense_Mutation | rs778782844 | c.1439N>T | p.Ser480Leu | p.S480L | Q8TE49 | protein_coding | deleterious(0.02) | benign(0.198) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
OTUD7A | insertion | Frame_Shift_Ins | novel | c.1191_1192insGA | p.Leu398AspfsTer31 | p.L398Dfs*31 | Q8TE49 | protein_coding | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
OTUD7A | SNV | Missense_Mutation | novel | c.32N>T | p.Ser11Leu | p.S11L | Q8TE49 | protein_coding | tolerated_low_confidence(0.15) | benign(0.114) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
OTUD7A | SNV | Missense_Mutation | novel | c.1277C>T | p.Ser426Leu | p.S426L | Q8TE49 | protein_coding | deleterious(0.01) | probably_damaging(0.978) | TCGA-A5-A0G5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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