![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ORM1 |
Gene summary for ORM1 |
![]() |
Gene information | Species | Human | Gene symbol | ORM1 | Gene ID | 5004 |
Gene name | orosomucoid 1 | |
Gene Alias | AGP-A | |
Cytomap | 9q32 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | P02763 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5004 | ORM1 | NAFLD1 | Human | Liver | NAFLD | 1.42e-03 | 2.97e-02 | -0.04 |
5004 | ORM1 | HCC1_Meng | Human | Liver | HCC | 6.61e-81 | 6.37e-01 | 0.0246 |
5004 | ORM1 | HCC2_Meng | Human | Liver | HCC | 8.79e-13 | -6.21e-01 | 0.0107 |
5004 | ORM1 | cirrhotic1 | Human | Liver | Cirrhotic | 6.37e-06 | -3.19e-01 | 0.0202 |
5004 | ORM1 | cirrhotic2 | Human | Liver | Cirrhotic | 5.51e-06 | -2.71e-01 | 0.0201 |
5004 | ORM1 | cirrhotic3 | Human | Liver | Cirrhotic | 1.29e-03 | -3.08e-01 | 0.0215 |
5004 | ORM1 | HCC1 | Human | Liver | HCC | 1.06e-16 | 4.22e+00 | 0.5336 |
5004 | ORM1 | HCC2 | Human | Liver | HCC | 1.32e-19 | 6.98e+00 | 0.5341 |
5004 | ORM1 | Pt13.a | Human | Liver | HCC | 5.33e-82 | 1.11e+00 | 0.021 |
5004 | ORM1 | Pt13.b | Human | Liver | HCC | 1.13e-94 | 1.01e+00 | 0.0251 |
5004 | ORM1 | Pt13.c | Human | Liver | HCC | 1.26e-17 | 6.54e-01 | 0.0076 |
5004 | ORM1 | Pt14.a | Human | Liver | HCC | 5.82e-12 | 4.81e-01 | 0.0169 |
5004 | ORM1 | Pt14.b | Human | Liver | HCC | 7.27e-27 | 7.14e-01 | 0.018 |
5004 | ORM1 | Pt14.c | Human | Liver | HCC | 2.79e-08 | 7.65e-01 | 0.0054 |
5004 | ORM1 | Pt14.d | Human | Liver | HCC | 3.07e-29 | 5.90e-01 | 0.0143 |
5004 | ORM1 | S027 | Human | Liver | HCC | 1.03e-21 | 3.18e+00 | 0.2446 |
5004 | ORM1 | S028 | Human | Liver | HCC | 1.74e-42 | 2.74e+00 | 0.2503 |
5004 | ORM1 | S029 | Human | Liver | HCC | 1.51e-60 | 4.41e+00 | 0.2581 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0002526 | Liver | NAFLD | acute inflammatory response | 26/1882 | 112/18723 | 3.68e-05 | 9.23e-04 | 26 |
GO:0006953 | Liver | NAFLD | acute-phase response | 13/1882 | 49/18723 | 8.43e-04 | 1.03e-02 | 13 |
GO:00069531 | Liver | Cirrhotic | acute-phase response | 23/4634 | 49/18723 | 6.06e-04 | 4.67e-03 | 23 |
GO:00025261 | Liver | Cirrhotic | acute inflammatory response | 40/4634 | 112/18723 | 6.16e-03 | 3.06e-02 | 40 |
GO:00025262 | Liver | HCC | acute inflammatory response | 62/7958 | 112/18723 | 4.06e-03 | 1.77e-02 | 62 |
GO:00069532 | Liver | HCC | acute-phase response | 30/7958 | 49/18723 | 6.31e-03 | 2.57e-02 | 30 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ORM1 | SNV | Missense_Mutation | novel | c.517G>T | p.Val173Phe | p.V173F | P02763 | protein_coding | deleterious(0) | benign(0.11) | TCGA-63-A5MN-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ORM1 | SNV | Missense_Mutation | novel | c.422G>A | p.Gly141Glu | p.G141E | P02763 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-85-8277-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ORM1 | SNV | Missense_Mutation | c.376N>G | p.Lys126Glu | p.K126E | P02763 | protein_coding | tolerated(0.35) | benign(0.15) | TCGA-CG-4462-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ORM1 | SNV | Missense_Mutation | rs146832261 | c.152N>A | p.Arg51Gln | p.R51Q | P02763 | protein_coding | deleterious(0.04) | benign(0.031) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ORM1 | SNV | Missense_Mutation | novel | c.163N>C | p.Tyr55His | p.Y55H | P02763 | protein_coding | deleterious(0) | benign(0.029) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
ORM1 | insertion | Nonsense_Mutation | novel | c.429_430insTACAGGTGA | p.Ser143_Val144insTyrArgTer | p.S143_V144insYR* | P02763 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |