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Gene: ORAI1 |
Gene summary for ORAI1 |
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Gene information | Species | Human | Gene symbol | ORAI1 | Gene ID | 84876 |
Gene name | ORAI calcium release-activated calcium modulator 1 | |
Gene Alias | CRACM1 | |
Cytomap | 12q24.31 | |
Gene Type | protein-coding | GO ID | GO:0002115 | UniProtAcc | A0A024RBT3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84876 | ORAI1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.40e-02 | 2.04e-01 | -0.0811 |
84876 | ORAI1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.68e-04 | 1.46e-01 | -0.1954 |
84876 | ORAI1 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.08e-03 | 2.04e-01 | -0.1526 |
84876 | ORAI1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.04e-10 | 3.32e-01 | -0.059 |
84876 | ORAI1 | HTA11_546_2000001011 | Human | Colorectum | AD | 6.59e-05 | 2.62e-01 | -0.0842 |
84876 | ORAI1 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.36e-04 | 1.61e-01 | 0.096 |
84876 | ORAI1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.33e-03 | 1.55e-01 | 0.0338 |
84876 | ORAI1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.96e-06 | 2.24e-01 | 0.0674 |
84876 | ORAI1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.95e-03 | 1.79e-01 | 0.294 |
84876 | ORAI1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.40e-03 | 5.57e-01 | 0.3487 |
84876 | ORAI1 | LZE24T | Human | Esophagus | ESCC | 6.95e-04 | 1.69e-01 | 0.0596 |
84876 | ORAI1 | P2T-E | Human | Esophagus | ESCC | 4.91e-50 | 9.04e-01 | 0.1177 |
84876 | ORAI1 | P4T-E | Human | Esophagus | ESCC | 8.64e-23 | 5.03e-01 | 0.1323 |
84876 | ORAI1 | P5T-E | Human | Esophagus | ESCC | 1.70e-08 | 1.80e-01 | 0.1327 |
84876 | ORAI1 | P8T-E | Human | Esophagus | ESCC | 1.42e-05 | 5.40e-02 | 0.0889 |
84876 | ORAI1 | P9T-E | Human | Esophagus | ESCC | 2.02e-03 | 1.46e-01 | 0.1131 |
84876 | ORAI1 | P10T-E | Human | Esophagus | ESCC | 1.91e-05 | 6.17e-02 | 0.116 |
84876 | ORAI1 | P11T-E | Human | Esophagus | ESCC | 1.56e-07 | 2.44e-01 | 0.1426 |
84876 | ORAI1 | P12T-E | Human | Esophagus | ESCC | 4.54e-09 | 1.56e-01 | 0.1122 |
84876 | ORAI1 | P16T-E | Human | Esophagus | ESCC | 1.53e-13 | 2.90e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:0030879 | Colorectum | AD | mammary gland development | 53/3918 | 137/18723 | 1.46e-06 | 4.58e-05 | 53 |
GO:0061180 | Colorectum | AD | mammary gland epithelium development | 28/3918 | 67/18723 | 8.74e-05 | 1.35e-03 | 28 |
GO:00487321 | Colorectum | SER | gland development | 112/2897 | 436/18723 | 1.75e-08 | 1.28e-06 | 112 |
GO:00611801 | Colorectum | SER | mammary gland epithelium development | 22/2897 | 67/18723 | 3.11e-04 | 5.03e-03 | 22 |
GO:00308791 | Colorectum | SER | mammary gland development | 37/2897 | 137/18723 | 3.61e-04 | 5.61e-03 | 37 |
GO:00487322 | Colorectum | MSS | gland development | 143/3467 | 436/18723 | 3.85e-13 | 8.01e-11 | 143 |
GO:00308792 | Colorectum | MSS | mammary gland development | 51/3467 | 137/18723 | 1.88e-07 | 8.26e-06 | 51 |
GO:00611802 | Colorectum | MSS | mammary gland epithelium development | 28/3467 | 67/18723 | 8.47e-06 | 2.11e-04 | 28 |
GO:0051349 | Colorectum | MSS | positive regulation of lyase activity | 10/3467 | 23/18723 | 5.06e-03 | 3.47e-02 | 10 |
GO:00487323 | Colorectum | MSI-H | gland development | 53/1319 | 436/18723 | 7.08e-05 | 2.35e-03 | 53 |
GO:0048732111 | Esophagus | ESCC | gland development | 269/8552 | 436/18723 | 7.81e-12 | 2.95e-10 | 269 |
GO:003087914 | Esophagus | ESCC | mammary gland development | 85/8552 | 137/18723 | 8.11e-05 | 6.01e-04 | 85 |
GO:00611807 | Esophagus | ESCC | mammary gland epithelium development | 43/8552 | 67/18723 | 1.73e-03 | 7.97e-03 | 43 |
GO:004873222 | Liver | HCC | gland development | 242/7958 | 436/18723 | 2.26e-08 | 5.28e-07 | 242 |
GO:00308795 | Liver | HCC | mammary gland development | 75/7958 | 137/18723 | 2.52e-03 | 1.22e-02 | 75 |
GO:004873220 | Oral cavity | OSCC | gland development | 226/7305 | 436/18723 | 2.78e-08 | 5.39e-07 | 226 |
GO:003087910 | Oral cavity | OSCC | mammary gland development | 69/7305 | 137/18723 | 4.43e-03 | 1.79e-02 | 69 |
GO:0048732110 | Oral cavity | LP | gland development | 149/4623 | 436/18723 | 4.51e-06 | 9.17e-05 | 149 |
GO:004873227 | Skin | cSCC | gland development | 167/4864 | 436/18723 | 7.64e-09 | 2.44e-07 | 167 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa046112 | Liver | HCC | Platelet activation | 71/4020 | 124/8465 | 1.77e-02 | 4.15e-02 | 2.31e-02 | 71 |
hsa0461111 | Liver | HCC | Platelet activation | 71/4020 | 124/8465 | 1.77e-02 | 4.15e-02 | 2.31e-02 | 71 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ORAI1 | SNV | Missense_Mutation | rs529121117 | c.142N>A | p.Ala48Thr | p.A48T | protein_coding | tolerated(0.58) | benign(0.007) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ORAI1 | deletion | In_Frame_Del | novel | c.145_150delNNNNNN | p.His50_Asp51del | p.H50_D51del | protein_coding | TCGA-CG-4475-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
84876 | ORAI1 | TRANSCRIPTION FACTOR, ION CHANNEL, TRANSPORTER | CM2489 | |||
84876 | ORAI1 | TRANSCRIPTION FACTOR, ION CHANNEL, TRANSPORTER | blocker | 381118797 | ||
84876 | ORAI1 | TRANSCRIPTION FACTOR, ION CHANNEL, TRANSPORTER | blocker | 381118798 | ||
84876 | ORAI1 | TRANSCRIPTION FACTOR, ION CHANNEL, TRANSPORTER | RP4010 | |||
84876 | ORAI1 | TRANSCRIPTION FACTOR, ION CHANNEL, TRANSPORTER | blocker | 375973230 | ||
84876 | ORAI1 | TRANSCRIPTION FACTOR, ION CHANNEL, TRANSPORTER | blocker | 375973229 |
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