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Gene: NXPH3 |
Gene summary for NXPH3 |
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Gene information | Species | Human | Gene symbol | NXPH3 | Gene ID | 11248 |
Gene name | neurexophilin 3 | |
Gene Alias | NPH3 | |
Cytomap | 17q21.33 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | O95157 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11248 | NXPH3 | S014 | Human | Liver | HCC | 3.64e-16 | 4.24e-01 | 0.2254 |
11248 | NXPH3 | S015 | Human | Liver | HCC | 1.61e-18 | 8.00e-01 | 0.2375 |
11248 | NXPH3 | S016 | Human | Liver | HCC | 7.39e-22 | 5.12e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NXPH3 | SNV | Missense_Mutation | c.519N>A | p.Phe173Leu | p.F173L | O95157 | protein_coding | tolerated(0.12) | benign(0.095) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response | |
NXPH3 | deletion | Frame_Shift_Del | c.272delC | p.Pro91HisfsTer6 | p.P91Hfs*6 | O95157 | protein_coding | TCGA-B5-A0JU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
NXPH3 | SNV | Missense_Mutation | c.596G>T | p.Cys199Phe | p.C199F | O95157 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-05-4430-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NXPH3 | SNV | Missense_Mutation | novel | c.64G>A | p.Gly22Ser | p.G22S | O95157 | protein_coding | deleterious(0.04) | benign(0.346) | TCGA-33-AASI-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | PD |
NXPH3 | SNV | Missense_Mutation | c.278C>T | p.Ser93Leu | p.S93L | O95157 | protein_coding | tolerated(0.07) | benign(0.179) | TCGA-39-5029-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | docetaxel | PD | |
NXPH3 | SNV | Missense_Mutation | novel | c.574A>G | p.Thr192Ala | p.T192A | O95157 | protein_coding | tolerated(0.59) | benign(0.072) | TCGA-58-8392-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NXPH3 | SNV | Missense_Mutation | novel | c.604N>T | p.Asp202Tyr | p.D202Y | O95157 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-CN-6012-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD |
NXPH3 | SNV | Missense_Mutation | novel | c.271N>T | p.Pro91Ser | p.P91S | O95157 | protein_coding | tolerated(0.9) | benign(0) | TCGA-CQ-A4C9-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
NXPH3 | SNV | Missense_Mutation | novel | c.164C>A | p.Pro55His | p.P55H | O95157 | protein_coding | deleterious(0.04) | benign(0.011) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NXPH3 | SNV | Missense_Mutation | rs781447574 | c.104N>A | p.Arg35His | p.R35H | O95157 | protein_coding | tolerated(0.35) | benign(0) | TCGA-FP-A4BE-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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