Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/NUCB1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/NUCB1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/NUCB1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/NUCB1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/NUCB1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/NUCB1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/NUCB1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/NUCB1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006605 | Colorectum | AD | protein targeting | 105/3918 | 314/18723 | 1.39e-07 | 6.44e-06 | 105 |
GO:0032386 | Colorectum | AD | regulation of intracellular transport | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0033157 | Colorectum | AD | regulation of intracellular protein transport | 80/3918 | 229/18723 | 5.81e-07 | 2.09e-05 | 80 |
GO:1903533 | Colorectum | AD | regulation of protein targeting | 31/3918 | 81/18723 | 2.61e-04 | 3.25e-03 | 31 |
GO:00331571 | Colorectum | SER | regulation of intracellular protein transport | 68/2897 | 229/18723 | 3.41e-08 | 2.30e-06 | 68 |
GO:00323861 | Colorectum | SER | regulation of intracellular transport | 89/2897 | 337/18723 | 1.34e-07 | 7.96e-06 | 89 |
GO:00066051 | Colorectum | SER | protein targeting | 76/2897 | 314/18723 | 3.19e-05 | 8.47e-04 | 76 |
GO:19035331 | Colorectum | SER | regulation of protein targeting | 24/2897 | 81/18723 | 9.20e-04 | 1.11e-02 | 24 |
GO:00066052 | Colorectum | MSS | protein targeting | 97/3467 | 314/18723 | 6.76e-08 | 3.46e-06 | 97 |
GO:00331572 | Colorectum | MSS | regulation of intracellular protein transport | 76/3467 | 229/18723 | 7.03e-08 | 3.56e-06 | 76 |
GO:00323862 | Colorectum | MSS | regulation of intracellular transport | 102/3467 | 337/18723 | 9.73e-08 | 4.71e-06 | 102 |
GO:19035332 | Colorectum | MSS | regulation of protein targeting | 28/3467 | 81/18723 | 4.34e-04 | 5.23e-03 | 28 |
GO:00066053 | Colorectum | MSI-H | protein targeting | 44/1319 | 314/18723 | 9.50e-06 | 4.55e-04 | 44 |
GO:00323863 | Colorectum | MSI-H | regulation of intracellular transport | 46/1319 | 337/18723 | 1.20e-05 | 5.48e-04 | 46 |
GO:00331573 | Colorectum | MSI-H | regulation of intracellular protein transport | 33/1319 | 229/18723 | 6.86e-05 | 2.29e-03 | 33 |
GO:00323865 | Colorectum | CRC | regulation of intracellular transport | 61/2078 | 337/18723 | 7.94e-05 | 1.65e-03 | 61 |
GO:00331575 | Colorectum | CRC | regulation of intracellular protein transport | 45/2078 | 229/18723 | 9.62e-05 | 1.95e-03 | 45 |
GO:00066055 | Colorectum | CRC | protein targeting | 54/2078 | 314/18723 | 7.17e-04 | 9.28e-03 | 54 |
GO:000660525 | Esophagus | HGIN | protein targeting | 78/2587 | 314/18723 | 1.08e-07 | 5.47e-06 | 78 |
GO:003238617 | Esophagus | HGIN | regulation of intracellular transport | 79/2587 | 337/18723 | 1.11e-06 | 4.36e-05 | 79 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUCB1 | deletion | In_Frame_Del | novel | c.902_909+4delTGAAGAATGTGA | | | Q02818 | protein_coding | | | TCGA-DF-A2KR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
NUCB1 | SNV | Missense_Mutation | novel | c.284N>C | p.His95Pro | p.H95P | Q02818 | protein_coding | deleterious(0.01) | possibly_damaging(0.613) | TCGA-44-2666-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
NUCB1 | SNV | Missense_Mutation | | c.608N>T | p.Glu203Val | p.E203V | Q02818 | protein_coding | deleterious(0.03) | possibly_damaging(0.735) | TCGA-18-3410-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NUCB1 | SNV | Missense_Mutation | | c.867N>T | p.Met289Ile | p.M289I | Q02818 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-33-4582-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
NUCB1 | SNV | Missense_Mutation | | c.532N>A | p.Arg178Ser | p.R178S | Q02818 | protein_coding | deleterious(0) | possibly_damaging(0.66) | TCGA-33-A5GW-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NUCB1 | SNV | Missense_Mutation | novel | c.1189G>C | p.Glu397Gln | p.E397Q | Q02818 | protein_coding | deleterious(0.03) | benign(0.329) | TCGA-37-3792-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NUCB1 | SNV | Missense_Mutation | rs749759537 | c.64C>T | p.Arg22Cys | p.R22C | Q02818 | protein_coding | tolerated(0.15) | benign(0.129) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
NUCB1 | SNV | Missense_Mutation | novel | c.695G>T | p.Trp232Leu | p.W232L | Q02818 | protein_coding | deleterious(0.02) | possibly_damaging(0.745) | TCGA-NC-A5HI-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
NUCB1 | SNV | Missense_Mutation | novel | c.988N>A | p.Gly330Arg | p.G330R | Q02818 | protein_coding | tolerated(0.1) | benign(0.026) | TCGA-CV-5970-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
NUCB1 | SNV | Missense_Mutation | novel | c.956N>T | p.Ala319Val | p.A319V | Q02818 | protein_coding | tolerated(0.3) | benign(0.197) | TCGA-CV-A6JM-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |