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Gene: NR3C2 |
Gene summary for NR3C2 |
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Gene information | Species | Human | Gene symbol | NR3C2 | Gene ID | 4306 |
Gene name | nuclear receptor subfamily 3 group C member 2 | |
Gene Alias | MCR | |
Cytomap | 4q31.23 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B0ZBF6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4306 | NR3C2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.33e-50 | -9.03e-01 | 0.0155 |
4306 | NR3C2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.50e-06 | -8.57e-01 | 0.0216 |
4306 | NR3C2 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.33e-25 | 1.00e+00 | -0.1954 |
4306 | NR3C2 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.42e-13 | 9.07e-01 | -0.2602 |
4306 | NR3C2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.17e-10 | 7.07e-01 | -0.2196 |
4306 | NR3C2 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.86e-02 | 3.26e-01 | -0.1526 |
4306 | NR3C2 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.17e-10 | 6.02e-01 | -0.1464 |
4306 | NR3C2 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.49e-11 | 6.02e-01 | -0.1001 |
4306 | NR3C2 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.59e-15 | -6.77e-01 | 0.096 |
4306 | NR3C2 | HTA11_9408_2000001011 | Human | Colorectum | AD | 4.39e-05 | -5.90e-01 | 0.0451 |
4306 | NR3C2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.59e-09 | -8.33e-01 | 0.0528 |
4306 | NR3C2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.50e-08 | -5.34e-01 | 0.0338 |
4306 | NR3C2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.59e-31 | -7.81e-01 | 0.0674 |
4306 | NR3C2 | HTA11_7469_2000001011 | Human | Colorectum | AD | 5.39e-03 | -6.79e-01 | -0.0124 |
4306 | NR3C2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 5.35e-32 | -9.89e-01 | 0.0588 |
4306 | NR3C2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.70e-79 | -1.20e+00 | 0.294 |
4306 | NR3C2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.83e-71 | -1.18e+00 | 0.3859 |
4306 | NR3C2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.69e-36 | -1.30e+00 | 0.2585 |
4306 | NR3C2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.24e-111 | -1.59e+00 | 0.3005 |
4306 | NR3C2 | F007 | Human | Colorectum | FAP | 9.75e-04 | -3.49e-01 | 0.1176 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0071383 | Colorectum | AD | cellular response to steroid hormone stimulus | 73/3918 | 204/18723 | 6.31e-07 | 2.24e-05 | 73 |
GO:0030522 | Colorectum | AD | intracellular receptor signaling pathway | 87/3918 | 265/18723 | 3.69e-06 | 1.03e-04 | 87 |
GO:0043401 | Colorectum | AD | steroid hormone mediated signaling pathway | 51/3918 | 136/18723 | 6.52e-06 | 1.63e-04 | 51 |
GO:0048545 | Colorectum | AD | response to steroid hormone | 104/3918 | 339/18723 | 1.33e-05 | 2.90e-04 | 104 |
GO:0009755 | Colorectum | AD | hormone-mediated signaling pathway | 64/3918 | 190/18723 | 2.78e-05 | 5.24e-04 | 64 |
GO:0030518 | Colorectum | AD | intracellular steroid hormone receptor signaling pathway | 43/3918 | 116/18723 | 4.61e-05 | 7.97e-04 | 43 |
GO:00713831 | Colorectum | SER | cellular response to steroid hormone stimulus | 55/2897 | 204/18723 | 1.66e-05 | 5.05e-04 | 55 |
GO:00485451 | Colorectum | SER | response to steroid hormone | 80/2897 | 339/18723 | 5.15e-05 | 1.25e-03 | 80 |
GO:00434011 | Colorectum | SER | steroid hormone mediated signaling pathway | 38/2897 | 136/18723 | 1.42e-04 | 2.82e-03 | 38 |
GO:00097551 | Colorectum | SER | hormone-mediated signaling pathway | 49/2897 | 190/18723 | 1.54e-04 | 3.00e-03 | 49 |
GO:00305221 | Colorectum | SER | intracellular receptor signaling pathway | 63/2897 | 265/18723 | 2.47e-04 | 4.20e-03 | 63 |
GO:00305181 | Colorectum | SER | intracellular steroid hormone receptor signaling pathway | 31/2897 | 116/18723 | 1.25e-03 | 1.41e-02 | 31 |
GO:00713832 | Colorectum | MSS | cellular response to steroid hormone stimulus | 72/3467 | 204/18723 | 8.87e-09 | 5.43e-07 | 72 |
GO:00434012 | Colorectum | MSS | steroid hormone mediated signaling pathway | 51/3467 | 136/18723 | 1.43e-07 | 6.67e-06 | 51 |
GO:00305222 | Colorectum | MSS | intracellular receptor signaling pathway | 84/3467 | 265/18723 | 1.47e-07 | 6.79e-06 | 84 |
GO:00485452 | Colorectum | MSS | response to steroid hormone | 101/3467 | 339/18723 | 2.60e-07 | 1.10e-05 | 101 |
GO:00305182 | Colorectum | MSS | intracellular steroid hormone receptor signaling pathway | 44/3467 | 116/18723 | 6.95e-07 | 2.49e-05 | 44 |
GO:00097552 | Colorectum | MSS | hormone-mediated signaling pathway | 63/3467 | 190/18723 | 9.26e-07 | 3.23e-05 | 63 |
GO:00713833 | Colorectum | FAP | cellular response to steroid hormone stimulus | 59/2622 | 204/18723 | 2.12e-08 | 2.06e-06 | 59 |
GO:00485454 | Colorectum | FAP | response to steroid hormone | 81/2622 | 339/18723 | 6.22e-07 | 3.08e-05 | 81 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04960 | Colorectum | FAP | Aldosterone-regulated sodium reabsorption | 13/1404 | 37/8465 | 4.79e-03 | 1.91e-02 | 1.16e-02 | 13 |
hsa049601 | Colorectum | FAP | Aldosterone-regulated sodium reabsorption | 13/1404 | 37/8465 | 4.79e-03 | 1.91e-02 | 1.16e-02 | 13 |
hsa049602 | Colorectum | CRC | Aldosterone-regulated sodium reabsorption | 12/1091 | 37/8465 | 1.66e-03 | 1.20e-02 | 8.16e-03 | 12 |
hsa049603 | Colorectum | CRC | Aldosterone-regulated sodium reabsorption | 12/1091 | 37/8465 | 1.66e-03 | 1.20e-02 | 8.16e-03 | 12 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NR3C2 | SNV | Missense_Mutation | c.2741N>A | p.Ser914Tyr | p.S914Y | protein_coding | deleterious(0.02) | probably_damaging(0.992) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | ||
NR3C2 | SNV | Missense_Mutation | novel | c.170N>C | p.Asn57Thr | p.N57T | protein_coding | deleterious_low_confidence(0) | benign(0.007) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NR3C2 | SNV | Missense_Mutation | c.593N>G | p.Leu198Arg | p.L198R | protein_coding | tolerated_low_confidence(0.12) | benign(0.051) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
NR3C2 | SNV | Missense_Mutation | novel | c.2465N>T | p.Thr822Met | p.T822M | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
NR3C2 | SNV | Missense_Mutation | rs552665133 | c.1769N>A | p.Arg590Gln | p.R590Q | protein_coding | deleterious(0.01) | possibly_damaging(0.831) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
NR3C2 | SNV | Missense_Mutation | novel | c.1455N>C | p.Glu485Asp | p.E485D | protein_coding | tolerated(0.13) | benign(0.18) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
NR3C2 | SNV | Missense_Mutation | c.2134N>A | p.Ala712Thr | p.A712T | protein_coding | tolerated(0.3) | benign(0.01) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
NR3C2 | SNV | Missense_Mutation | c.752N>A | p.Pro251His | p.P251H | protein_coding | deleterious_low_confidence(0.01) | benign(0.029) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
NR3C2 | SNV | Missense_Mutation | rs751757447 | c.535N>A | p.Ala179Thr | p.A179T | protein_coding | tolerated_low_confidence(0.61) | benign(0) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NR3C2 | SNV | Missense_Mutation | rs773405588 | c.52N>T | p.Arg18Trp | p.R18W | protein_coding | deleterious_low_confidence(0) | benign(0.386) | TCGA-AG-A016-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4306 | NR3C2 | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | agonist | CHEMBL1200592 | DESOXYCORTICOSTERONE PIVALATE | |
4306 | NR3C2 | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | PMID27551786-Compound-106 | |||
4306 | NR3C2 | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | agonist | 135651469 | ||
4306 | NR3C2 | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | antagonist | 135651551 | PROGESTERONE | |
4306 | NR3C2 | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | antagonist | 135650760 | ONAPRISTONE | |
4306 | NR3C2 | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | PROGESTERONE | PROGESTERONE | ||
4306 | NR3C2 | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | FLUDROCORTISONE | FLUDROCORTISONE | ||
4306 | NR3C2 | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | KBP-5074 | |||
4306 | NR3C2 | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | PMID27551786-Compound-II | |||
4306 | NR3C2 | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | EPLERENONE | EPLERENONE |
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