![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: NR2F6 |
Gene summary for NR2F6 |
![]() |
Gene information | Species | Human | Gene symbol | NR2F6 | Gene ID | 2063 |
Gene name | nuclear receptor subfamily 2 group F member 6 | |
Gene Alias | EAR-2 | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | F1D8R3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2063 | NR2F6 | GSM4909290 | Human | Breast | IDC | 2.20e-02 | 2.54e-01 | 0.2096 |
2063 | NR2F6 | GSM4909291 | Human | Breast | IDC | 3.78e-03 | 3.29e-01 | 0.1753 |
2063 | NR2F6 | GSM4909293 | Human | Breast | IDC | 7.58e-19 | 4.38e-01 | 0.1581 |
2063 | NR2F6 | GSM4909298 | Human | Breast | IDC | 5.78e-15 | 3.94e-01 | 0.1551 |
2063 | NR2F6 | GSM4909301 | Human | Breast | IDC | 1.36e-03 | 2.93e-01 | 0.1577 |
2063 | NR2F6 | GSM4909304 | Human | Breast | IDC | 1.22e-25 | 5.47e-01 | 0.1636 |
2063 | NR2F6 | GSM4909311 | Human | Breast | IDC | 5.00e-09 | -3.26e-02 | 0.1534 |
2063 | NR2F6 | GSM4909317 | Human | Breast | IDC | 7.40e-05 | 2.94e-01 | 0.1355 |
2063 | NR2F6 | GSM4909319 | Human | Breast | IDC | 4.34e-13 | 2.58e-02 | 0.1563 |
2063 | NR2F6 | GSM4909320 | Human | Breast | IDC | 1.45e-09 | 5.35e-01 | 0.1575 |
2063 | NR2F6 | GSM4909321 | Human | Breast | IDC | 3.28e-30 | 7.20e-01 | 0.1559 |
2063 | NR2F6 | M1 | Human | Breast | IDC | 5.19e-17 | 6.08e-01 | 0.1577 |
2063 | NR2F6 | NCCBC14 | Human | Breast | DCIS | 3.11e-04 | 2.99e-01 | 0.2021 |
2063 | NR2F6 | P1 | Human | Breast | IDC | 3.46e-08 | 2.72e-01 | 0.1527 |
2063 | NR2F6 | DCIS2 | Human | Breast | DCIS | 2.69e-52 | 2.18e-01 | 0.0085 |
2063 | NR2F6 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.21e-05 | 5.58e-01 | -0.1808 |
2063 | NR2F6 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.45e-02 | 2.07e-01 | -0.0811 |
2063 | NR2F6 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.85e-04 | 3.82e-01 | -0.1088 |
2063 | NR2F6 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.99e-17 | 5.34e-01 | -0.1954 |
2063 | NR2F6 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.96e-03 | 8.43e-01 | -0.2602 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000926612 | Breast | IDC | response to temperature stimulus | 34/1434 | 178/18723 | 5.88e-07 | 2.83e-05 | 34 |
GO:000931412 | Breast | IDC | response to radiation | 62/1434 | 456/18723 | 6.91e-06 | 2.10e-04 | 62 |
GO:003052214 | Breast | IDC | intracellular receptor signaling pathway | 37/1434 | 265/18723 | 2.77e-04 | 4.26e-03 | 37 |
GO:00485117 | Breast | IDC | rhythmic process | 38/1434 | 298/18723 | 1.34e-03 | 1.39e-02 | 38 |
GO:000931422 | Breast | DCIS | response to radiation | 62/1390 | 456/18723 | 2.56e-06 | 8.87e-05 | 62 |
GO:000926621 | Breast | DCIS | response to temperature stimulus | 30/1390 | 178/18723 | 1.91e-05 | 4.56e-04 | 30 |
GO:003052224 | Breast | DCIS | intracellular receptor signaling pathway | 35/1390 | 265/18723 | 6.38e-04 | 7.92e-03 | 35 |
GO:004851113 | Breast | DCIS | rhythmic process | 37/1390 | 298/18723 | 1.44e-03 | 1.47e-02 | 37 |
GO:0030522 | Colorectum | AD | intracellular receptor signaling pathway | 87/3918 | 265/18723 | 3.69e-06 | 1.03e-04 | 87 |
GO:0007623 | Colorectum | AD | circadian rhythm | 72/3918 | 210/18723 | 4.50e-06 | 1.21e-04 | 72 |
GO:0048511 | Colorectum | AD | rhythmic process | 94/3918 | 298/18723 | 1.00e-05 | 2.34e-04 | 94 |
GO:0042752 | Colorectum | AD | regulation of circadian rhythm | 40/3918 | 121/18723 | 1.24e-03 | 1.09e-02 | 40 |
GO:00076231 | Colorectum | SER | circadian rhythm | 54/2897 | 210/18723 | 7.98e-05 | 1.77e-03 | 54 |
GO:00305221 | Colorectum | SER | intracellular receptor signaling pathway | 63/2897 | 265/18723 | 2.47e-04 | 4.20e-03 | 63 |
GO:00485111 | Colorectum | SER | rhythmic process | 65/2897 | 298/18723 | 2.18e-03 | 2.11e-02 | 65 |
GO:00427521 | Colorectum | SER | regulation of circadian rhythm | 30/2897 | 121/18723 | 5.03e-03 | 3.88e-02 | 30 |
GO:00305222 | Colorectum | MSS | intracellular receptor signaling pathway | 84/3467 | 265/18723 | 1.47e-07 | 6.79e-06 | 84 |
GO:00076232 | Colorectum | MSS | circadian rhythm | 69/3467 | 210/18723 | 4.22e-07 | 1.67e-05 | 69 |
GO:00485112 | Colorectum | MSS | rhythmic process | 89/3467 | 298/18723 | 1.17e-06 | 3.96e-05 | 89 |
GO:00427522 | Colorectum | MSS | regulation of circadian rhythm | 38/3467 | 121/18723 | 4.33e-04 | 5.23e-03 | 38 |
Page: 1 2 3 4 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 2 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NR2F6 | SNV | Missense_Mutation | novel | c.848N>A | p.Arg283His | p.R283H | P10588 | protein_coding | deleterious(0.03) | probably_damaging(0.921) | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD |
NR2F6 | SNV | Missense_Mutation | rs773419411 | c.1075N>A | p.Ala359Thr | p.A359T | P10588 | protein_coding | tolerated(0.05) | benign(0.403) | TCGA-VQ-A8PB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |