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Gene: NR0B2 |
Gene summary for NR0B2 |
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Gene information | Species | Human | Gene symbol | NR0B2 | Gene ID | 8431 |
Gene name | nuclear receptor subfamily 0 group B member 2 | |
Gene Alias | SHP | |
Cytomap | 1p36.11 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q15466 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8431 | NR0B2 | S43 | Human | Liver | Cirrhotic | 2.68e-09 | -2.61e-01 | -0.0187 |
8431 | NR0B2 | HCC1_Meng | Human | Liver | HCC | 1.64e-64 | -4.91e-02 | 0.0246 |
8431 | NR0B2 | HCC2_Meng | Human | Liver | HCC | 5.54e-08 | -3.15e-01 | 0.0107 |
8431 | NR0B2 | cirrhotic1 | Human | Liver | Cirrhotic | 1.88e-13 | 3.70e-01 | 0.0202 |
8431 | NR0B2 | cirrhotic2 | Human | Liver | Cirrhotic | 1.55e-08 | 1.82e-01 | 0.0201 |
8431 | NR0B2 | HCC2 | Human | Liver | HCC | 3.34e-04 | 2.85e+00 | 0.5341 |
8431 | NR0B2 | Pt13.b | Human | Liver | HCC | 1.87e-04 | 5.60e-02 | 0.0251 |
8431 | NR0B2 | Pt13.c | Human | Liver | HCC | 1.96e-02 | -3.21e-01 | 0.0076 |
8431 | NR0B2 | S014 | Human | Liver | HCC | 2.05e-02 | 1.05e+00 | 0.2254 |
8431 | NR0B2 | S015 | Human | Liver | HCC | 3.04e-02 | 9.68e-01 | 0.2375 |
8431 | NR0B2 | S016 | Human | Liver | HCC | 4.34e-12 | 1.48e+00 | 0.2243 |
8431 | NR0B2 | S027 | Human | Liver | HCC | 1.81e-06 | 1.74e+00 | 0.2446 |
8431 | NR0B2 | S028 | Human | Liver | HCC | 3.55e-17 | 1.58e+00 | 0.2503 |
8431 | NR0B2 | S029 | Human | Liver | HCC | 4.38e-26 | 2.39e+00 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000820211 | Liver | Cirrhotic | steroid metabolic process | 143/4634 | 319/18723 | 2.79e-15 | 3.18e-13 | 143 |
GO:190495112 | Liver | Cirrhotic | positive regulation of establishment of protein localization | 135/4634 | 319/18723 | 3.20e-12 | 2.28e-10 | 135 |
GO:19026521 | Liver | Cirrhotic | secondary alcohol metabolic process | 75/4634 | 147/18723 | 5.62e-12 | 3.91e-10 | 75 |
GO:00082031 | Liver | Cirrhotic | cholesterol metabolic process | 70/4634 | 137/18723 | 2.59e-11 | 1.55e-09 | 70 |
GO:00161251 | Liver | Cirrhotic | sterol metabolic process | 75/4634 | 152/18723 | 4.54e-11 | 2.61e-09 | 75 |
GO:005122212 | Liver | Cirrhotic | positive regulation of protein transport | 126/4634 | 303/18723 | 6.85e-11 | 3.77e-09 | 126 |
GO:000606612 | Liver | Cirrhotic | alcohol metabolic process | 141/4634 | 353/18723 | 1.57e-10 | 8.03e-09 | 141 |
GO:000974312 | Liver | Cirrhotic | response to carbohydrate | 101/4634 | 253/18723 | 6.24e-08 | 1.92e-06 | 101 |
GO:003428412 | Liver | Cirrhotic | response to monosaccharide | 90/4634 | 225/18723 | 2.87e-07 | 7.01e-06 | 90 |
GO:000762312 | Liver | Cirrhotic | circadian rhythm | 84/4634 | 210/18723 | 7.04e-07 | 1.50e-05 | 84 |
GO:000974612 | Liver | Cirrhotic | response to hexose | 86/4634 | 219/18723 | 1.30e-06 | 2.59e-05 | 86 |
GO:009730512 | Liver | Cirrhotic | response to alcohol | 96/4634 | 253/18723 | 1.97e-06 | 3.65e-05 | 96 |
GO:00097497 | Liver | Cirrhotic | response to glucose | 82/4634 | 212/18723 | 4.54e-06 | 7.51e-05 | 82 |
GO:00329221 | Liver | Cirrhotic | circadian regulation of gene expression | 34/4634 | 68/18723 | 6.04e-06 | 9.74e-05 | 34 |
GO:003110011 | Liver | Cirrhotic | animal organ regeneration | 35/4634 | 76/18723 | 4.26e-05 | 5.03e-04 | 35 |
GO:001087611 | Liver | Cirrhotic | lipid localization | 147/4634 | 448/18723 | 6.24e-05 | 7.12e-04 | 147 |
GO:004851111 | Liver | Cirrhotic | rhythmic process | 103/4634 | 298/18723 | 8.47e-05 | 9.19e-04 | 103 |
GO:003109911 | Liver | Cirrhotic | regeneration | 71/4634 | 198/18723 | 3.02e-04 | 2.65e-03 | 71 |
GO:000686911 | Liver | Cirrhotic | lipid transport | 128/4634 | 398/18723 | 4.54e-04 | 3.69e-03 | 128 |
GO:00454711 | Liver | Cirrhotic | response to ethanol | 48/4634 | 137/18723 | 4.45e-03 | 2.35e-02 | 48 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NR0B2 | SNV | Missense_Mutation | rs756121300 | c.713N>A | p.Arg238His | p.R238H | Q15466 | protein_coding | deleterious(0.04) | benign(0.244) | TCGA-HU-A4H3-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | ts-1 | PD |
NR0B2 | SNV | Missense_Mutation | novel | c.398G>A | p.Gly133Asp | p.G133D | Q15466 | protein_coding | tolerated(0.27) | benign(0.09) | TCGA-IN-A7NT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | leucovorin | SD |
NR0B2 | SNV | Missense_Mutation | novel | c.407C>T | p.Pro136Leu | p.P136L | Q15466 | protein_coding | tolerated(0.09) | benign(0.027) | TCGA-VQ-A91K-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8431 | NR0B2 | TRANSCRIPTION FACTOR BINDING, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | 252827495 |
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