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Gene: NFIX |
Gene summary for NFIX |
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Gene information | Species | Human | Gene symbol | NFIX | Gene ID | 4784 |
Gene name | nuclear factor I X | |
Gene Alias | CTF | |
Cytomap | 19p13.13 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | B4DHW2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4784 | NFIX | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.79e-02 | 1.39e-01 | 0.0155 |
4784 | NFIX | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.95e-02 | 2.57e-01 | -0.0811 |
4784 | NFIX | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.13e-03 | 4.49e-01 | 0.0338 |
4784 | NFIX | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.93e-11 | 7.39e-01 | 0.0674 |
4784 | NFIX | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.40e-04 | 5.52e-01 | 0.0588 |
4784 | NFIX | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.04e-09 | 7.38e-01 | 0.281 |
4784 | NFIX | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.09e-13 | 7.79e-01 | 0.3859 |
4784 | NFIX | A015-C-203 | Human | Colorectum | FAP | 8.92e-11 | -2.05e-02 | -0.1294 |
4784 | NFIX | A001-C-108 | Human | Colorectum | FAP | 6.40e-07 | 1.40e-01 | -0.0272 |
4784 | NFIX | A002-C-205 | Human | Colorectum | FAP | 6.21e-04 | -7.71e-02 | -0.1236 |
4784 | NFIX | A015-C-106 | Human | Colorectum | FAP | 1.61e-05 | 2.00e-01 | -0.0511 |
4784 | NFIX | A002-C-114 | Human | Colorectum | FAP | 1.89e-02 | -8.35e-02 | -0.1561 |
4784 | NFIX | A015-C-104 | Human | Colorectum | FAP | 8.13e-14 | 1.06e-01 | -0.1899 |
4784 | NFIX | A001-C-014 | Human | Colorectum | FAP | 2.35e-03 | 8.15e-02 | 0.0135 |
4784 | NFIX | A002-C-016 | Human | Colorectum | FAP | 5.45e-06 | -2.01e-02 | 0.0521 |
4784 | NFIX | A001-C-203 | Human | Colorectum | FAP | 2.04e-04 | 8.55e-02 | -0.0481 |
4784 | NFIX | A002-C-116 | Human | Colorectum | FAP | 1.06e-14 | -1.32e-01 | -0.0452 |
4784 | NFIX | A018-E-020 | Human | Colorectum | FAP | 5.07e-03 | -1.05e-01 | -0.2034 |
4784 | NFIX | F034 | Human | Colorectum | FAP | 1.74e-09 | 1.04e-01 | -0.0665 |
4784 | NFIX | F072B | Human | Colorectum | FAP | 1.14e-02 | -6.00e-02 | 0.257 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:00062601 | Liver | HCC | DNA replication | 146/7958 | 260/18723 | 5.68e-06 | 7.02e-05 | 146 |
GO:00062605 | Skin | AK | DNA replication | 40/1910 | 260/18723 | 5.49e-03 | 3.03e-02 | 40 |
GO:000626012 | Skin | cSCC | DNA replication | 106/4864 | 260/18723 | 1.18e-07 | 2.77e-06 | 106 |
GO:00062606 | Thyroid | PTC | DNA replication | 114/5968 | 260/18723 | 3.09e-05 | 2.95e-04 | 114 |
GO:000626013 | Thyroid | ATC | DNA replication | 124/6293 | 260/18723 | 1.58e-06 | 1.93e-05 | 124 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NFIX | SNV | Missense_Mutation | c.383N>T | p.Arg128Leu | p.R128L | Q14938 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-78-7633-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NFIX | SNV | Missense_Mutation | novel | c.936G>T | p.Trp312Cys | p.W312C | Q14938 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NFIX | SNV | Missense_Mutation | novel | c.686N>A | p.Arg229Lys | p.R229K | Q14938 | protein_coding | tolerated(0.07) | probably_damaging(0.986) | TCGA-MT-A67F-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NFIX | SNV | Missense_Mutation | c.1121C>T | p.Thr374Met | p.T374M | Q14938 | protein_coding | deleterious(0.01) | possibly_damaging(0.785) | TCGA-BR-A4QM-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
NFIX | SNV | Missense_Mutation | rs755556407 | c.790N>T | p.Arg264Trp | p.R264W | Q14938 | protein_coding | deleterious(0) | possibly_damaging(0.797) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NFIX | SNV | Missense_Mutation | c.1274C>T | p.Pro425Leu | p.P425L | Q14938 | protein_coding | deleterious(0.01) | possibly_damaging(0.531) | TCGA-F1-6874-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NFIX | SNV | Missense_Mutation | c.1156C>T | p.His386Tyr | p.H386Y | Q14938 | protein_coding | deleterious(0.05) | probably_damaging(0.974) | TCGA-FP-A4BE-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
NFIX | SNV | Missense_Mutation | rs762562838 | c.1028G>A | p.Arg343His | p.R343H | Q14938 | protein_coding | deleterious(0.02) | benign(0.003) | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NFIX | SNV | Missense_Mutation | novel | c.877G>A | p.Val293Met | p.V293M | Q14938 | protein_coding | tolerated(0.18) | probably_damaging(0.997) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
NFIX | SNV | Missense_Mutation | novel | c.709A>G | p.Thr237Ala | p.T237A | Q14938 | protein_coding | tolerated(0.23) | benign(0.079) | TCGA-DE-A69J-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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