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Gene: NFE2L3 |
Gene summary for NFE2L3 |
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Gene information | Species | Human | Gene symbol | NFE2L3 | Gene ID | 9603 |
Gene name | nuclear factor, erythroid 2 like 3 | |
Gene Alias | NRF3 | |
Cytomap | 7p15.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9Y4A8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9603 | NFE2L3 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.01e-02 | 3.57e-01 | 0.0588 |
9603 | NFE2L3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.15e-24 | 7.45e-01 | 0.294 |
9603 | NFE2L3 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.51e-03 | 8.41e-01 | 0.3487 |
9603 | NFE2L3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.24e-07 | 4.38e-01 | 0.3859 |
9603 | NFE2L3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.79e-10 | 3.89e-01 | 0.3005 |
9603 | NFE2L3 | A015-C-104 | Human | Colorectum | FAP | 4.02e-02 | -8.51e-02 | -0.1899 |
9603 | NFE2L3 | AEH-subject1 | Human | Endometrium | AEH | 8.57e-03 | 1.96e-01 | -0.3059 |
9603 | NFE2L3 | AEH-subject3 | Human | Endometrium | AEH | 9.98e-08 | 3.76e-01 | -0.2576 |
9603 | NFE2L3 | AEH-subject4 | Human | Endometrium | AEH | 5.33e-12 | 4.55e-01 | -0.2657 |
9603 | NFE2L3 | AEH-subject5 | Human | Endometrium | AEH | 2.71e-06 | 2.23e-01 | -0.2953 |
9603 | NFE2L3 | EEC-subject1 | Human | Endometrium | EEC | 8.23e-28 | 7.39e-01 | -0.2682 |
9603 | NFE2L3 | EEC-subject4 | Human | Endometrium | EEC | 1.46e-08 | 3.27e-01 | -0.2571 |
9603 | NFE2L3 | EEC-subject5 | Human | Endometrium | EEC | 3.56e-05 | 2.14e-01 | -0.249 |
9603 | NFE2L3 | GSM5276935 | Human | Endometrium | EEC | 3.38e-09 | 2.48e-01 | -0.123 |
9603 | NFE2L3 | LZE7T | Human | Esophagus | ESCC | 1.02e-03 | 1.85e-01 | 0.0667 |
9603 | NFE2L3 | LZE24T | Human | Esophagus | ESCC | 1.46e-02 | 1.11e-01 | 0.0596 |
9603 | NFE2L3 | P2T-E | Human | Esophagus | ESCC | 3.00e-96 | 1.78e+00 | 0.1177 |
9603 | NFE2L3 | P4T-E | Human | Esophagus | ESCC | 4.48e-22 | 4.82e-01 | 0.1323 |
9603 | NFE2L3 | P5T-E | Human | Esophagus | ESCC | 7.08e-04 | 1.17e-01 | 0.1327 |
9603 | NFE2L3 | P9T-E | Human | Esophagus | ESCC | 3.82e-08 | 2.24e-01 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NFE2L3 | SNV | Missense_Mutation | rs374797223 | c.1775N>T | p.Ala592Val | p.A592V | Q9Y4A8 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
NFE2L3 | SNV | Missense_Mutation | rs566561270 | c.1610G>A | p.Arg537His | p.R537H | Q9Y4A8 | protein_coding | deleterious(0.05) | possibly_damaging(0.735) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
NFE2L3 | SNV | Missense_Mutation | novel | c.1254T>G | p.Asp418Glu | p.D418E | Q9Y4A8 | protein_coding | tolerated(0.09) | benign(0.063) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
NFE2L3 | SNV | Missense_Mutation | rs551577266 | c.1936T>G | p.Phe646Val | p.F646V | Q9Y4A8 | protein_coding | deleterious(0) | possibly_damaging(0.647) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
NFE2L3 | SNV | Missense_Mutation | c.790N>C | p.Asp264His | p.D264H | Q9Y4A8 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NFE2L3 | SNV | Missense_Mutation | rs566561270 | c.1610N>A | p.Arg537His | p.R537H | Q9Y4A8 | protein_coding | deleterious(0.05) | possibly_damaging(0.735) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NFE2L3 | SNV | Missense_Mutation | rs779702861 | c.1022N>A | p.Pro341Gln | p.P341Q | Q9Y4A8 | protein_coding | tolerated(0.16) | benign(0.007) | TCGA-D5-6898-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NFE2L3 | SNV | Missense_Mutation | rs767647938 | c.1469N>T | p.Thr490Ile | p.T490I | Q9Y4A8 | protein_coding | tolerated(0.17) | benign(0.01) | TCGA-DM-A28A-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
NFE2L3 | SNV | Missense_Mutation | c.1304C>G | p.Ser435Cys | p.S435C | Q9Y4A8 | protein_coding | tolerated(0.07) | benign(0.015) | TCGA-AH-6549-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
NFE2L3 | SNV | Missense_Mutation | c.1625C>A | p.Ala542Asp | p.A542D | Q9Y4A8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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