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Gene: NECAP1 |
Gene summary for NECAP1 |
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Gene information | Species | Human | Gene symbol | NECAP1 | Gene ID | 25977 |
Gene name | NECAP endocytosis associated 1 | |
Gene Alias | DEE21 | |
Cytomap | 12p13.31 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8NC96 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25977 | NECAP1 | LZE4T | Human | Esophagus | ESCC | 2.44e-03 | 1.07e-01 | 0.0811 |
25977 | NECAP1 | LZE7T | Human | Esophagus | ESCC | 7.88e-06 | 2.58e-01 | 0.0667 |
25977 | NECAP1 | LZE8T | Human | Esophagus | ESCC | 1.65e-11 | 3.29e-01 | 0.067 |
25977 | NECAP1 | LZE20T | Human | Esophagus | ESCC | 1.20e-03 | 1.64e-01 | 0.0662 |
25977 | NECAP1 | LZE24T | Human | Esophagus | ESCC | 2.78e-16 | 3.09e-01 | 0.0596 |
25977 | NECAP1 | LZE6T | Human | Esophagus | ESCC | 4.45e-02 | 1.12e-01 | 0.0845 |
25977 | NECAP1 | P1T-E | Human | Esophagus | ESCC | 8.89e-05 | 1.46e-01 | 0.0875 |
25977 | NECAP1 | P2T-E | Human | Esophagus | ESCC | 1.12e-18 | 4.17e-01 | 0.1177 |
25977 | NECAP1 | P4T-E | Human | Esophagus | ESCC | 5.77e-24 | 5.09e-01 | 0.1323 |
25977 | NECAP1 | P5T-E | Human | Esophagus | ESCC | 1.48e-18 | 2.69e-01 | 0.1327 |
25977 | NECAP1 | P8T-E | Human | Esophagus | ESCC | 3.44e-15 | 2.11e-01 | 0.0889 |
25977 | NECAP1 | P9T-E | Human | Esophagus | ESCC | 9.04e-03 | 9.31e-02 | 0.1131 |
25977 | NECAP1 | P10T-E | Human | Esophagus | ESCC | 1.42e-28 | 3.48e-01 | 0.116 |
25977 | NECAP1 | P11T-E | Human | Esophagus | ESCC | 1.33e-13 | 3.39e-01 | 0.1426 |
25977 | NECAP1 | P12T-E | Human | Esophagus | ESCC | 4.56e-31 | 6.41e-01 | 0.1122 |
25977 | NECAP1 | P15T-E | Human | Esophagus | ESCC | 1.79e-16 | 3.68e-01 | 0.1149 |
25977 | NECAP1 | P16T-E | Human | Esophagus | ESCC | 7.50e-68 | 1.29e+00 | 0.1153 |
25977 | NECAP1 | P17T-E | Human | Esophagus | ESCC | 8.63e-05 | 1.62e-01 | 0.1278 |
25977 | NECAP1 | P20T-E | Human | Esophagus | ESCC | 9.90e-14 | 2.54e-01 | 0.1124 |
25977 | NECAP1 | P21T-E | Human | Esophagus | ESCC | 8.24e-14 | 2.19e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NECAP1 | SNV | Missense_Mutation | novel | c.667N>G | p.Ser223Gly | p.S223G | protein_coding | tolerated(0.13) | benign(0.01) | TCGA-56-8082-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NECAP1 | SNV | Missense_Mutation | novel | c.722N>T | p.Ala241Val | p.A241V | protein_coding | tolerated(0.2) | probably_damaging(0.935) | TCGA-94-8490-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NECAP1 | SNV | Missense_Mutation | novel | c.31C>G | p.Leu11Val | p.L11V | protein_coding | tolerated(0.12) | benign(0.119) | TCGA-98-A539-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
NECAP1 | SNV | Missense_Mutation | novel | c.338N>A | p.Arg113Gln | p.R113Q | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-D6-6516-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NECAP1 | SNV | Missense_Mutation | rs764080699 | c.569C>T | p.Pro190Leu | p.P190L | protein_coding | deleterious(0.02) | probably_damaging(0.992) | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD | |
NECAP1 | SNV | Missense_Mutation | c.110N>T | p.Lys37Ile | p.K37I | protein_coding | deleterious(0) | possibly_damaging(0.871) | TCGA-BR-6564-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
NECAP1 | SNV | Missense_Mutation | c.614N>T | p.Ala205Val | p.A205V | protein_coding | tolerated(0.3) | benign(0.051) | TCGA-BR-8371-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | ||
NECAP1 | SNV | Missense_Mutation | c.115N>A | p.Asp39Asn | p.D39N | protein_coding | deleterious(0.02) | possibly_damaging(0.738) | TCGA-CG-4444-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR | ||
NECAP1 | insertion | In_Frame_Ins | novel | c.171_172insTCTTTCTACCTATTA | p.Tyr57_Ile58insSerPheTyrLeuLeu | p.Y57_I58insSFYLL | protein_coding | TCGA-DJ-A3VL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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