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Gene: NAALADL1 |
Gene summary for NAALADL1 |
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Gene information | Species | Human | Gene symbol | NAALADL1 | Gene ID | 10004 |
Gene name | N-acetylated alpha-linked acidic dipeptidase like 1 | |
Gene Alias | I100 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q9UQQ1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10004 | NAALADL1 | S014 | Human | Liver | HCC | 5.79e-11 | 3.72e-01 | 0.2254 |
10004 | NAALADL1 | S015 | Human | Liver | HCC | 3.30e-26 | 8.05e-01 | 0.2375 |
10004 | NAALADL1 | S016 | Human | Liver | HCC | 2.69e-25 | 6.94e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NAALADL1 | SNV | Missense_Mutation | rs201373743 | c.2068N>A | p.Val690Ile | p.V690I | Q9UQQ1 | protein_coding | tolerated(0.39) | possibly_damaging(0.511) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
NAALADL1 | SNV | Missense_Mutation | rs201373743 | c.2068N>A | p.Val690Ile | p.V690I | Q9UQQ1 | protein_coding | tolerated(0.39) | possibly_damaging(0.511) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NAALADL1 | SNV | Missense_Mutation | rs143716055 | c.661N>A | p.Asp221Asn | p.D221N | Q9UQQ1 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-D5-5538-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | calcium | PD |
NAALADL1 | SNV | Missense_Mutation | rs369091785 | c.2027N>A | p.Arg676His | p.R676H | Q9UQQ1 | protein_coding | tolerated(0.14) | possibly_damaging(0.781) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NAALADL1 | SNV | Missense_Mutation | rs765242328 | c.2057N>A | p.Arg686His | p.R686H | Q9UQQ1 | protein_coding | tolerated(0.07) | possibly_damaging(0.714) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NAALADL1 | SNV | Missense_Mutation | c.907G>A | p.Ala303Thr | p.A303T | Q9UQQ1 | protein_coding | deleterious(0.02) | possibly_damaging(0.688) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NAALADL1 | SNV | Missense_Mutation | c.1594N>C | p.Asp532His | p.D532H | Q9UQQ1 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-DC-6681-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
NAALADL1 | insertion | Frame_Shift_Ins | novel | c.93_94insA | p.Ala32SerfsTer46 | p.A32Sfs*46 | Q9UQQ1 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
NAALADL1 | insertion | Nonsense_Mutation | novel | c.1807_1808insAGTTACTACAGTGAGACACTCCGCAGCTTCCTGCAGGCAG | p.Ala603GlufsTer5 | p.A603Efs*5 | Q9UQQ1 | protein_coding | TCGA-AA-3496-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
NAALADL1 | deletion | Frame_Shift_Del | c.2060delN | p.Thr687ArgfsTer4 | p.T687Rfs*4 | Q9UQQ1 | protein_coding | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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