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Gene: MZF1 |
Gene summary for MZF1 |
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Gene information | Species | Human | Gene symbol | MZF1 | Gene ID | 7593 |
Gene name | myeloid zinc finger 1 | |
Gene Alias | MZF-1 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P28698 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7593 | MZF1 | male-WTA | Human | Thyroid | PTC | 2.59e-08 | 7.30e-02 | 0.1037 |
7593 | MZF1 | PTC01 | Human | Thyroid | PTC | 2.44e-16 | 1.82e-01 | 0.1899 |
7593 | MZF1 | PTC03 | Human | Thyroid | PTC | 4.17e-03 | 1.61e-01 | 0.1784 |
7593 | MZF1 | PTC04 | Human | Thyroid | PTC | 4.22e-14 | 2.39e-01 | 0.1927 |
7593 | MZF1 | PTC05 | Human | Thyroid | PTC | 7.38e-21 | 5.34e-01 | 0.2065 |
7593 | MZF1 | PTC06 | Human | Thyroid | PTC | 4.53e-29 | 4.76e-01 | 0.2057 |
7593 | MZF1 | PTC07 | Human | Thyroid | PTC | 1.18e-19 | 3.59e-01 | 0.2044 |
7593 | MZF1 | ATC09 | Human | Thyroid | ATC | 1.24e-05 | 1.76e-01 | 0.2871 |
7593 | MZF1 | ATC12 | Human | Thyroid | ATC | 5.24e-05 | 5.57e-02 | 0.34 |
7593 | MZF1 | ATC13 | Human | Thyroid | ATC | 9.22e-17 | 1.39e-01 | 0.34 |
7593 | MZF1 | ATC1 | Human | Thyroid | ATC | 1.72e-06 | 2.11e-01 | 0.2878 |
7593 | MZF1 | ATC2 | Human | Thyroid | ATC | 2.98e-07 | 3.98e-01 | 0.34 |
7593 | MZF1 | ATC4 | Human | Thyroid | ATC | 1.03e-04 | 7.49e-02 | 0.34 |
7593 | MZF1 | ATC5 | Human | Thyroid | ATC | 8.69e-21 | 1.50e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MZF1 | SNV | Missense_Mutation | rs371153551 | c.866C>G | p.Ser289Cys | p.S289C | P28698 | protein_coding | tolerated(0.14) | benign(0.122) | TCGA-AJ-A2QM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
MZF1 | SNV | Missense_Mutation | novel | c.226N>A | p.Glu76Lys | p.E76K | P28698 | protein_coding | tolerated(0.06) | benign(0.094) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MZF1 | SNV | Missense_Mutation | rs200472691 | c.220N>T | p.Arg74Cys | p.R74C | P28698 | protein_coding | deleterious(0) | possibly_damaging(0.765) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MZF1 | SNV | Missense_Mutation | novel | c.511C>T | p.Pro171Ser | p.P171S | P28698 | protein_coding | tolerated(0.69) | benign(0.001) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MZF1 | SNV | Missense_Mutation | novel | c.269A>G | p.Glu90Gly | p.E90G | P28698 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MZF1 | SNV | Missense_Mutation | novel | c.2081C>T | p.Pro694Leu | p.P694L | P28698 | protein_coding | tolerated(0.1) | benign(0.43) | TCGA-AX-A1C5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | SD |
MZF1 | SNV | Missense_Mutation | novel | c.593N>A | p.Ser198Tyr | p.S198Y | P28698 | protein_coding | tolerated(0.18) | benign(0.127) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
MZF1 | SNV | Missense_Mutation | novel | c.223N>A | p.Pro75Thr | p.P75T | P28698 | protein_coding | deleterious(0) | possibly_damaging(0.56) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
MZF1 | SNV | Missense_Mutation | rs769188539 | c.2060N>A | p.Gly687Asp | p.G687D | P28698 | protein_coding | deleterious(0.03) | benign(0.255) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
MZF1 | SNV | Missense_Mutation | c.964N>A | p.Pro322Thr | p.P322T | P28698 | protein_coding | tolerated(0.12) | benign(0) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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