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Gene: MYRIP |
Gene summary for MYRIP |
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Gene information | Species | Human | Gene symbol | MYRIP | Gene ID | 25924 |
Gene name | myosin VIIA and Rab interacting protein | |
Gene Alias | SLAC2-C | |
Cytomap | 3p22.1 | |
Gene Type | protein-coding | GO ID | GO:0002790 | UniProtAcc | Q8NFW9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25924 | MYRIP | HTA11_696_2000001011 | Human | Colorectum | AD | 2.57e-05 | 4.11e-01 | -0.1464 |
25924 | MYRIP | HTA11_866_2000001011 | Human | Colorectum | AD | 2.95e-10 | 5.35e-01 | -0.1001 |
25924 | MYRIP | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.15e-08 | 5.95e-01 | -0.059 |
25924 | MYRIP | HTA11_866_3004761011 | Human | Colorectum | AD | 1.61e-05 | 3.36e-01 | 0.096 |
25924 | MYRIP | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.50e-12 | 6.81e-01 | 0.0338 |
25924 | MYRIP | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.30e-04 | 2.68e-01 | 0.0674 |
25924 | MYRIP | HTA11_6818_2000001021 | Human | Colorectum | AD | 6.91e-04 | 4.48e-01 | 0.0588 |
25924 | MYRIP | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.64e-09 | 3.91e-01 | 0.294 |
25924 | MYRIP | HTA11_99999965104_69814 | Human | Colorectum | MSS | 8.79e-09 | 8.15e-01 | 0.281 |
25924 | MYRIP | HTA11_99999971662_82457 | Human | Colorectum | MSS | 9.46e-22 | 7.17e-01 | 0.3859 |
25924 | MYRIP | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.79e-08 | 2.94e-01 | 0.3005 |
25924 | MYRIP | F007 | Human | Colorectum | FAP | 4.53e-20 | 1.07e+00 | 0.1176 |
25924 | MYRIP | A002-C-010 | Human | Colorectum | FAP | 1.74e-21 | 7.14e-01 | 0.242 |
25924 | MYRIP | A001-C-207 | Human | Colorectum | FAP | 1.52e-09 | 7.13e-01 | 0.1278 |
25924 | MYRIP | A015-C-203 | Human | Colorectum | FAP | 2.29e-12 | 6.08e-01 | -0.1294 |
25924 | MYRIP | A014-C-040 | Human | Colorectum | FAP | 1.36e-03 | 7.53e-01 | -0.1184 |
25924 | MYRIP | A002-C-201 | Human | Colorectum | FAP | 7.34e-09 | 6.32e-01 | 0.0324 |
25924 | MYRIP | A002-C-203 | Human | Colorectum | FAP | 3.40e-06 | 4.75e-01 | 0.2786 |
25924 | MYRIP | A001-C-108 | Human | Colorectum | FAP | 1.11e-11 | 6.48e-01 | -0.0272 |
25924 | MYRIP | A002-C-021 | Human | Colorectum | FAP | 6.64e-31 | 8.76e-01 | 0.1171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1904951 | Colorectum | AD | positive regulation of establishment of protein localization | 112/3918 | 319/18723 | 2.55e-09 | 1.80e-07 | 112 |
GO:0051222 | Colorectum | AD | positive regulation of protein transport | 106/3918 | 303/18723 | 8.45e-09 | 5.08e-07 | 106 |
GO:0050708 | Colorectum | AD | regulation of protein secretion | 83/3918 | 268/18723 | 6.59e-05 | 1.07e-03 | 83 |
GO:0009306 | Colorectum | AD | protein secretion | 105/3918 | 359/18723 | 1.05e-04 | 1.57e-03 | 105 |
GO:0035592 | Colorectum | AD | establishment of protein localization to extracellular region | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
GO:0071692 | Colorectum | AD | protein localization to extracellular region | 106/3918 | 368/18723 | 1.86e-04 | 2.49e-03 | 106 |
GO:0050796 | Colorectum | AD | regulation of insulin secretion | 54/3918 | 165/18723 | 2.60e-04 | 3.25e-03 | 54 |
GO:0051047 | Colorectum | AD | positive regulation of secretion | 90/3918 | 310/18723 | 4.11e-04 | 4.66e-03 | 90 |
GO:0030073 | Colorectum | AD | insulin secretion | 61/3918 | 195/18723 | 4.28e-04 | 4.81e-03 | 61 |
GO:1903532 | Colorectum | AD | positive regulation of secretion by cell | 82/3918 | 282/18723 | 6.85e-04 | 7.00e-03 | 82 |
GO:0015833 | Colorectum | AD | peptide transport | 77/3918 | 264/18723 | 8.90e-04 | 8.60e-03 | 77 |
GO:0090087 | Colorectum | AD | regulation of peptide transport | 60/3918 | 202/18723 | 1.94e-03 | 1.58e-02 | 60 |
GO:0030072 | Colorectum | AD | peptide hormone secretion | 68/3918 | 236/18723 | 2.39e-03 | 1.85e-02 | 68 |
GO:0002791 | Colorectum | AD | regulation of peptide secretion | 59/3918 | 200/18723 | 2.50e-03 | 1.92e-02 | 59 |
GO:0090276 | Colorectum | AD | regulation of peptide hormone secretion | 58/3918 | 196/18723 | 2.51e-03 | 1.92e-02 | 58 |
GO:0002790 | Colorectum | AD | peptide secretion | 69/3918 | 242/18723 | 2.97e-03 | 2.22e-02 | 69 |
GO:0042886 | Colorectum | AD | amide transport | 83/3918 | 301/18723 | 3.37e-03 | 2.46e-02 | 83 |
GO:0032024 | Colorectum | AD | positive regulation of insulin secretion | 27/3918 | 78/18723 | 3.52e-03 | 2.54e-02 | 27 |
GO:0050714 | Colorectum | AD | positive regulation of protein secretion | 42/3918 | 137/18723 | 4.64e-03 | 3.16e-02 | 42 |
GO:19049512 | Colorectum | MSS | positive regulation of establishment of protein localization | 110/3467 | 319/18723 | 6.30e-12 | 9.83e-10 | 110 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MYRIP | SNV | Missense_Mutation | rs572572991 | c.316N>A | p.Val106Ile | p.V106I | Q8NFW9 | protein_coding | tolerated(0.19) | probably_damaging(0.92) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MYRIP | SNV | Missense_Mutation | novel | c.620N>G | p.Ser207Cys | p.S207C | Q8NFW9 | protein_coding | tolerated(0.13) | benign(0.015) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
MYRIP | SNV | Missense_Mutation | novel | c.1252N>T | p.Pro418Ser | p.P418S | Q8NFW9 | protein_coding | tolerated(1) | benign(0.007) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
MYRIP | SNV | Missense_Mutation | c.305N>T | p.Trp102Leu | p.W102L | Q8NFW9 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MYRIP | SNV | Missense_Mutation | c.1189N>C | p.Ser397Arg | p.S397R | Q8NFW9 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MYRIP | SNV | Missense_Mutation | c.2257N>T | p.Leu753Phe | p.L753F | Q8NFW9 | protein_coding | deleterious(0.01) | possibly_damaging(0.493) | TCGA-D5-6532-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MYRIP | SNV | Missense_Mutation | c.2330N>A | p.Arg777His | p.R777H | Q8NFW9 | protein_coding | tolerated(0.22) | benign(0.025) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MYRIP | SNV | Missense_Mutation | c.744N>C | p.Gln248His | p.Q248H | Q8NFW9 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-AG-3592-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MYRIP | SNV | Missense_Mutation | c.1393G>A | p.Glu465Lys | p.E465K | Q8NFW9 | protein_coding | tolerated(0.15) | possibly_damaging(0.67) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MYRIP | SNV | Missense_Mutation | rs769986510 | c.196N>T | p.Arg66Cys | p.R66C | Q8NFW9 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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