![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MUC20 |
Gene summary for MUC20 |
![]() |
Gene information | Species | Human | Gene symbol | MUC20 | Gene ID | 200958 |
Gene name | mucin 20, cell surface associated | |
Gene Alias | MUC-20 | |
Cytomap | 3q29 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q8N307 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
200958 | MUC20 | H2 | Human | Cervix | HSIL_HPV | 6.59e-19 | 5.53e-01 | 0.0632 |
200958 | MUC20 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.93e-03 | 2.39e-01 | -0.1808 |
200958 | MUC20 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.11e-04 | 5.74e-01 | 0.0216 |
200958 | MUC20 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.07e-14 | 5.78e-01 | -0.0811 |
200958 | MUC20 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.34e-25 | 5.77e-01 | -0.1954 |
200958 | MUC20 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.68e-03 | 5.58e-01 | -0.2602 |
200958 | MUC20 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.86e-05 | 4.96e-01 | -0.2196 |
200958 | MUC20 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.50e-03 | 2.56e-01 | -0.1207 |
200958 | MUC20 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.62e-02 | 2.86e-01 | -0.1526 |
200958 | MUC20 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.04e-13 | 3.97e-01 | -0.1464 |
200958 | MUC20 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.67e-17 | 4.55e-01 | -0.1001 |
200958 | MUC20 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.28e-09 | 3.55e-01 | -0.059 |
200958 | MUC20 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.63e-08 | 5.74e-01 | -0.2061 |
200958 | MUC20 | HTA11_5216_2000001011 | Human | Colorectum | SER | 6.33e-05 | 4.79e-01 | -0.1462 |
200958 | MUC20 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.40e-13 | 7.37e-01 | -0.0842 |
200958 | MUC20 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.97e-04 | 5.27e-01 | -0.00410000000000005 |
200958 | MUC20 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.76e-05 | 4.25e-01 | -0.0179 |
200958 | MUC20 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.30e-06 | 2.66e-01 | 0.096 |
200958 | MUC20 | HTA11_9408_2000001011 | Human | Colorectum | AD | 6.94e-03 | 4.25e-01 | 0.0451 |
200958 | MUC20 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.78e-03 | 3.16e-01 | 0.0528 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00480121 | Esophagus | HGIN | hepatocyte growth factor receptor signaling pathway | 6/2587 | 13/18723 | 4.97e-03 | 4.18e-02 | 6 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MUC20 | SNV | Missense_Mutation | novel | c.1779N>G | p.Asp593Glu | p.D593E | Q8N307 | protein_coding | tolerated(0.08) | benign(0.078) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MUC20 | SNV | Missense_Mutation | c.1367N>T | p.Ser456Phe | p.S456F | Q8N307 | protein_coding | tolerated(0.06) | possibly_damaging(0.868) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
MUC20 | SNV | Missense_Mutation | novel | c.375N>A | p.Phe126Tyr | p.F126Y | protein_coding | unknown(0) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MUC20 | SNV | Missense_Mutation | c.2113N>T | p.Arg705Cys | p.R705C | Q8N307 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
MUC20 | SNV | Missense_Mutation | novel | c.1381C>A | p.Leu461Met | p.L461M | Q8N307 | protein_coding | deleterious(0.03) | probably_damaging(0.982) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
MUC20 | SNV | Missense_Mutation | novel | c.1986C>A | p.Phe662Leu | p.F662L | Q8N307 | protein_coding | deleterious(0.01) | possibly_damaging(0.739) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
MUC20 | SNV | Missense_Mutation | novel | c.356N>T | p.Pro120Ser | p.P120S | protein_coding | tolerated_low_confidence(0.94) | unknown(0) | TCGA-AJ-A3OJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
MUC20 | SNV | Missense_Mutation | rs528684754 | c.343G>A | p.Ala115Thr | p.A115T | Q8N307 | protein_coding | tolerated(1) | benign(0) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
MUC20 | SNV | Missense_Mutation | novel | c.1586N>T | p.Pro529Leu | p.P529L | Q8N307 | protein_coding | tolerated(0.08) | benign(0.031) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MUC20 | SNV | Missense_Mutation | c.2085C>G | p.His695Gln | p.H695Q | Q8N307 | protein_coding | deleterious(0.01) | possibly_damaging(0.463) | TCGA-AP-A05A-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |