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Gene: MTHFD1L |
Gene summary for MTHFD1L |
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Gene information | Species | Human | Gene symbol | MTHFD1L | Gene ID | 25902 |
Gene name | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like | |
Gene Alias | FTHFSDC1 | |
Cytomap | 6q25.1 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | B7ZM99 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25902 | MTHFD1L | CCI_1 | Human | Cervix | CC | 5.58e-14 | 1.12e+00 | 0.528 |
25902 | MTHFD1L | CCI_2 | Human | Cervix | CC | 1.74e-02 | 6.66e-01 | 0.5249 |
25902 | MTHFD1L | CCI_3 | Human | Cervix | CC | 4.38e-11 | 6.79e-01 | 0.516 |
25902 | MTHFD1L | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.50e-04 | 7.06e-01 | -0.059 |
25902 | MTHFD1L | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.43e-04 | 5.07e-01 | 0.294 |
25902 | MTHFD1L | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.87e-04 | 1.27e+00 | 0.3487 |
25902 | MTHFD1L | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.70e-11 | 9.06e-01 | 0.281 |
25902 | MTHFD1L | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.44e-21 | 1.01e+00 | 0.3859 |
25902 | MTHFD1L | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.48e-02 | 2.90e-01 | 0.3005 |
25902 | MTHFD1L | A015-C-203 | Human | Colorectum | FAP | 1.62e-05 | -2.85e-01 | -0.1294 |
25902 | MTHFD1L | A002-C-205 | Human | Colorectum | FAP | 1.40e-03 | -1.62e-01 | -0.1236 |
25902 | MTHFD1L | A002-C-114 | Human | Colorectum | FAP | 1.07e-02 | -1.64e-01 | -0.1561 |
25902 | MTHFD1L | A015-C-104 | Human | Colorectum | FAP | 3.30e-06 | -2.58e-01 | -0.1899 |
25902 | MTHFD1L | A002-C-016 | Human | Colorectum | FAP | 1.54e-02 | -1.63e-01 | 0.0521 |
25902 | MTHFD1L | A002-C-116 | Human | Colorectum | FAP | 4.56e-04 | -1.48e-01 | -0.0452 |
25902 | MTHFD1L | A018-E-020 | Human | Colorectum | FAP | 9.31e-06 | -2.64e-01 | -0.2034 |
25902 | MTHFD1L | AEH-subject1 | Human | Endometrium | AEH | 1.95e-13 | 5.35e-01 | -0.3059 |
25902 | MTHFD1L | AEH-subject2 | Human | Endometrium | AEH | 8.20e-13 | 5.07e-01 | -0.2525 |
25902 | MTHFD1L | AEH-subject4 | Human | Endometrium | AEH | 7.41e-05 | 3.55e-01 | -0.2657 |
25902 | MTHFD1L | AEH-subject5 | Human | Endometrium | AEH | 1.20e-06 | 3.89e-01 | -0.2953 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00351487 | Cervix | CC | tube formation | 31/2311 | 148/18723 | 2.07e-03 | 1.51e-02 | 31 |
GO:00018417 | Cervix | CC | neural tube formation | 23/2311 | 102/18723 | 2.80e-03 | 1.87e-02 | 23 |
GO:00605626 | Cervix | CC | epithelial tube morphogenesis | 57/2311 | 325/18723 | 3.79e-03 | 2.41e-02 | 57 |
GO:00140206 | Cervix | CC | primary neural tube formation | 21/2311 | 94/18723 | 4.68e-03 | 2.82e-02 | 21 |
GO:00219156 | Cervix | CC | neural tube development | 30/2311 | 152/18723 | 6.00e-03 | 3.43e-02 | 30 |
GO:00018435 | Cervix | CC | neural tube closure | 19/2311 | 88/18723 | 1.01e-02 | 4.91e-02 | 19 |
GO:0006575 | Colorectum | AD | cellular modified amino acid metabolic process | 59/3918 | 188/18723 | 4.80e-04 | 5.27e-03 | 59 |
GO:0006730 | Colorectum | AD | one-carbon metabolic process | 18/3918 | 40/18723 | 5.36e-04 | 5.74e-03 | 18 |
GO:0060562 | Colorectum | AD | epithelial tube morphogenesis | 93/3918 | 325/18723 | 5.65e-04 | 6.00e-03 | 93 |
GO:0043648 | Colorectum | AD | dicarboxylic acid metabolic process | 34/3918 | 96/18723 | 7.22e-04 | 7.28e-03 | 34 |
GO:0014020 | Colorectum | AD | primary neural tube formation | 33/3918 | 94/18723 | 1.02e-03 | 9.50e-03 | 33 |
GO:0001841 | Colorectum | AD | neural tube formation | 35/3918 | 102/18723 | 1.16e-03 | 1.05e-02 | 35 |
GO:0001843 | Colorectum | AD | neural tube closure | 30/3918 | 88/18723 | 2.83e-03 | 2.12e-02 | 30 |
GO:0060606 | Colorectum | AD | tube closure | 30/3918 | 89/18723 | 3.42e-03 | 2.49e-02 | 30 |
GO:0042398 | Colorectum | AD | cellular modified amino acid biosynthetic process | 18/3918 | 46/18723 | 3.67e-03 | 2.60e-02 | 18 |
GO:0035148 | Colorectum | AD | tube formation | 45/3918 | 148/18723 | 4.13e-03 | 2.87e-02 | 45 |
GO:0001838 | Colorectum | AD | embryonic epithelial tube formation | 38/3918 | 121/18723 | 4.40e-03 | 3.01e-02 | 38 |
GO:0048568 | Colorectum | AD | embryonic organ development | 112/3918 | 427/18723 | 4.60e-03 | 3.14e-02 | 112 |
GO:0072175 | Colorectum | AD | epithelial tube formation | 40/3918 | 132/18723 | 6.98e-03 | 4.29e-02 | 40 |
GO:0021915 | Colorectum | AD | neural tube development | 45/3918 | 152/18723 | 7.05e-03 | 4.31e-02 | 45 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00670 | Colorectum | MSI-H | One carbon pool by folate | 7/797 | 20/8465 | 1.65e-03 | 1.73e-02 | 1.45e-02 | 7 |
hsa006701 | Colorectum | MSI-H | One carbon pool by folate | 7/797 | 20/8465 | 1.65e-03 | 1.73e-02 | 1.45e-02 | 7 |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa012402 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa006702 | Liver | HCC | One carbon pool by folate | 17/4020 | 20/8465 | 6.04e-04 | 2.50e-03 | 1.39e-03 | 17 |
hsa012403 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa0067011 | Liver | HCC | One carbon pool by folate | 17/4020 | 20/8465 | 6.04e-04 | 2.50e-03 | 1.39e-03 | 17 |
hsa012404 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa0124011 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MTHFD1L | SNV | Missense_Mutation | c.1470N>G | p.Ile490Met | p.I490M | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
MTHFD1L | SNV | Missense_Mutation | c.1870N>A | p.Ala624Thr | p.A624T | protein_coding | tolerated(0.38) | benign(0.007) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
MTHFD1L | SNV | Missense_Mutation | c.2720N>A | p.Cys907Tyr | p.C907Y | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MTHFD1L | SNV | Missense_Mutation | rs766519360 | c.1018N>T | p.Arg340Cys | p.R340C | protein_coding | deleterious(0.01) | benign(0.409) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MTHFD1L | SNV | Missense_Mutation | novel | c.2166N>T | p.Glu722Asp | p.E722D | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MTHFD1L | SNV | Missense_Mutation | c.980N>A | p.Arg327Gln | p.R327Q | protein_coding | deleterious(0) | possibly_damaging(0.83) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | ||
MTHFD1L | SNV | Missense_Mutation | novel | c.2710T>G | p.Leu904Val | p.L904V | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MTHFD1L | SNV | Missense_Mutation | novel | c.2902C>A | p.Leu968Ile | p.L968I | protein_coding | tolerated(0.33) | possibly_damaging(0.557) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MTHFD1L | SNV | Missense_Mutation | c.2032N>C | p.Val678Leu | p.V678L | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-G5-6572-02 | Colorectum | NA | NA | NA | NA | NA | NA | NA | ||
MTHFD1L | deletion | Frame_Shift_Del | c.1762delA | p.Ile588Ter | p.I588* | protein_coding | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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