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Gene: MSANTD3 |
Gene summary for MSANTD3 |
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Gene information | Species | Human | Gene symbol | MSANTD3 | Gene ID | 91283 |
Gene name | Myb/SANT DNA binding domain containing 3 | |
Gene Alias | C9orf30 | |
Cytomap | 9q31.1 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A0A024R171 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91283 | MSANTD3 | GSM5276934 | Human | Endometrium | EEC | 3.05e-10 | 3.69e-01 | -0.0913 |
91283 | MSANTD3 | GSM5276937 | Human | Endometrium | EEC | 1.06e-19 | 5.12e-01 | -0.0897 |
91283 | MSANTD3 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 2.87e-06 | -2.15e-02 | -0.1869 |
91283 | MSANTD3 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 7.72e-05 | 3.83e-02 | -0.1875 |
91283 | MSANTD3 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 6.02e-08 | 1.92e-02 | -0.1883 |
91283 | MSANTD3 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 2.15e-05 | -6.96e-02 | -0.1917 |
91283 | MSANTD3 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 7.69e-08 | -8.40e-02 | -0.1916 |
91283 | MSANTD3 | LZE4T | Human | Esophagus | ESCC | 5.59e-05 | 1.91e-01 | 0.0811 |
91283 | MSANTD3 | LZE24T | Human | Esophagus | ESCC | 3.03e-04 | 5.63e-02 | 0.0596 |
91283 | MSANTD3 | P1T-E | Human | Esophagus | ESCC | 4.32e-05 | 1.15e-01 | 0.0875 |
91283 | MSANTD3 | P2T-E | Human | Esophagus | ESCC | 5.65e-16 | 4.03e-01 | 0.1177 |
91283 | MSANTD3 | P4T-E | Human | Esophagus | ESCC | 1.34e-19 | 4.57e-01 | 0.1323 |
91283 | MSANTD3 | P5T-E | Human | Esophagus | ESCC | 9.84e-17 | 3.67e-01 | 0.1327 |
91283 | MSANTD3 | P8T-E | Human | Esophagus | ESCC | 6.69e-06 | 9.94e-02 | 0.0889 |
91283 | MSANTD3 | P9T-E | Human | Esophagus | ESCC | 1.64e-13 | 2.43e-01 | 0.1131 |
91283 | MSANTD3 | P10T-E | Human | Esophagus | ESCC | 4.48e-16 | 9.81e-02 | 0.116 |
91283 | MSANTD3 | P11T-E | Human | Esophagus | ESCC | 3.02e-10 | 3.46e-01 | 0.1426 |
91283 | MSANTD3 | P12T-E | Human | Esophagus | ESCC | 1.46e-12 | 6.98e-02 | 0.1122 |
91283 | MSANTD3 | P15T-E | Human | Esophagus | ESCC | 6.96e-07 | 1.87e-01 | 0.1149 |
91283 | MSANTD3 | P16T-E | Human | Esophagus | ESCC | 1.15e-03 | 4.07e-02 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MSANTD3 | insertion | In_Frame_Ins | novel | c.101_102insGGGTTT | p.Cys34delinsTrpGlyPhe | p.C34delinsWGF | Q96H12 | protein_coding | TCGA-A5-A0R8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
MSANTD3 | SNV | Missense_Mutation | c.803N>G | p.Asn268Ser | p.N268S | Q96H12 | protein_coding | deleterious_low_confidence(0) | benign(0.019) | TCGA-05-4395-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
MSANTD3 | SNV | Missense_Mutation | novel | c.112N>A | p.Asp38Asn | p.D38N | Q96H12 | protein_coding | deleterious(0.04) | probably_damaging(0.972) | TCGA-05-4427-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
MSANTD3 | SNV | Missense_Mutation | novel | c.743N>T | p.Lys248Met | p.K248M | Q96H12 | protein_coding | tolerated_low_confidence(0.15) | probably_damaging(0.926) | TCGA-49-AARE-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
MSANTD3 | SNV | Missense_Mutation | c.806N>T | p.Arg269Leu | p.R269L | Q96H12 | protein_coding | deleterious_low_confidence(0.02) | benign(0.024) | TCGA-50-5930-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxotere | PD | |
MSANTD3 | SNV | Missense_Mutation | c.91G>C | p.Val31Leu | p.V31L | Q96H12 | protein_coding | deleterious(0.02) | probably_damaging(0.959) | TCGA-64-1678-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
MSANTD3 | SNV | Missense_Mutation | c.686N>G | p.Glu229Gly | p.E229G | Q96H12 | protein_coding | deleterious_low_confidence(0.03) | benign(0.054) | TCGA-73-4677-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
MSANTD3 | SNV | Missense_Mutation | c.355N>T | p.Leu119Phe | p.L119F | Q96H12 | protein_coding | tolerated(0.1) | benign(0.025) | TCGA-78-7153-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MSANTD3 | SNV | Missense_Mutation | c.182N>T | p.Ser61Ile | p.S61I | Q96H12 | protein_coding | tolerated(0.08) | possibly_damaging(0.861) | TCGA-86-8585-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MSANTD3 | SNV | Missense_Mutation | c.794N>T | p.Ser265Phe | p.S265F | Q96H12 | protein_coding | deleterious_low_confidence(0) | benign(0.136) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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