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Gene: MRPL39 |
Gene summary for MRPL39 |
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Gene information | Species | Human | Gene symbol | MRPL39 | Gene ID | 54148 |
Gene name | mitochondrial ribosomal protein L39 | |
Gene Alias | C21orf92 | |
Cytomap | 21q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000313 | UniProtAcc | Q9NYK5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54148 | MRPL39 | LZE4T | Human | Esophagus | ESCC | 4.62e-08 | 1.38e-01 | 0.0811 |
54148 | MRPL39 | LZE7T | Human | Esophagus | ESCC | 2.43e-04 | 1.92e-01 | 0.0667 |
54148 | MRPL39 | LZE24T | Human | Esophagus | ESCC | 2.23e-13 | 3.47e-01 | 0.0596 |
54148 | MRPL39 | P1T-E | Human | Esophagus | ESCC | 2.39e-06 | 1.67e-01 | 0.0875 |
54148 | MRPL39 | P2T-E | Human | Esophagus | ESCC | 9.29e-24 | 3.54e-01 | 0.1177 |
54148 | MRPL39 | P4T-E | Human | Esophagus | ESCC | 5.20e-34 | 8.64e-01 | 0.1323 |
54148 | MRPL39 | P5T-E | Human | Esophagus | ESCC | 2.81e-28 | 5.02e-01 | 0.1327 |
54148 | MRPL39 | P8T-E | Human | Esophagus | ESCC | 1.03e-16 | 2.43e-01 | 0.0889 |
54148 | MRPL39 | P9T-E | Human | Esophagus | ESCC | 1.04e-09 | 2.22e-01 | 0.1131 |
54148 | MRPL39 | P10T-E | Human | Esophagus | ESCC | 2.13e-24 | 3.81e-01 | 0.116 |
54148 | MRPL39 | P11T-E | Human | Esophagus | ESCC | 5.28e-10 | 2.75e-01 | 0.1426 |
54148 | MRPL39 | P12T-E | Human | Esophagus | ESCC | 1.96e-27 | 4.40e-01 | 0.1122 |
54148 | MRPL39 | P15T-E | Human | Esophagus | ESCC | 8.09e-12 | 1.89e-01 | 0.1149 |
54148 | MRPL39 | P16T-E | Human | Esophagus | ESCC | 3.66e-33 | 4.47e-01 | 0.1153 |
54148 | MRPL39 | P17T-E | Human | Esophagus | ESCC | 1.07e-05 | 2.55e-01 | 0.1278 |
54148 | MRPL39 | P19T-E | Human | Esophagus | ESCC | 1.72e-07 | 4.44e-01 | 0.1662 |
54148 | MRPL39 | P20T-E | Human | Esophagus | ESCC | 4.24e-14 | 1.70e-01 | 0.1124 |
54148 | MRPL39 | P21T-E | Human | Esophagus | ESCC | 6.06e-29 | 4.86e-01 | 0.1617 |
54148 | MRPL39 | P22T-E | Human | Esophagus | ESCC | 1.99e-28 | 3.80e-01 | 0.1236 |
54148 | MRPL39 | P23T-E | Human | Esophagus | ESCC | 1.62e-21 | 2.82e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRPL39 | SNV | Missense_Mutation | rs764499775 | c.289G>A | p.Glu97Lys | p.E97K | Q9NYK5 | protein_coding | deleterious(0.03) | benign(0.175) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MRPL39 | SNV | Missense_Mutation | rs756456682 | c.131N>A | p.Arg44Gln | p.R44Q | Q9NYK5 | protein_coding | tolerated(0.13) | benign(0.261) | TCGA-BS-A0UL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPL39 | SNV | Missense_Mutation | novel | c.483A>C | p.Glu161Asp | p.E161D | Q9NYK5 | protein_coding | tolerated(0.28) | benign(0.005) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPL39 | SNV | Missense_Mutation | c.182N>A | p.Arg61Gln | p.R61Q | Q9NYK5 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR | |
MRPL39 | SNV | Missense_Mutation | novel | c.944N>C | p.Lys315Thr | p.K315T | Q9NYK5 | protein_coding | tolerated(0.11) | benign(0.103) | TCGA-EY-A1GD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPL39 | SNV | Missense_Mutation | novel | c.85A>G | p.Thr29Ala | p.T29A | Q9NYK5 | protein_coding | tolerated(0.11) | benign(0.003) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPL39 | deletion | Frame_Shift_Del | novel | c.682delG | p.Glu228LysfsTer10 | p.E228Kfs*10 | Q9NYK5 | protein_coding | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | ||
MRPL39 | SNV | Missense_Mutation | c.749N>C | p.Arg250Thr | p.R250T | Q9NYK5 | protein_coding | tolerated(0.16) | benign(0.352) | TCGA-05-5428-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | |
MRPL39 | SNV | Missense_Mutation | c.722N>C | p.Glu241Ala | p.E241A | Q9NYK5 | protein_coding | tolerated(0.18) | benign(0.198) | TCGA-49-AARE-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
MRPL39 | SNV | Missense_Mutation | c.599N>T | p.Arg200Leu | p.R200L | Q9NYK5 | protein_coding | tolerated(0.07) | benign(0.118) | TCGA-64-1676-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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