![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MRPL2 |
Gene summary for MRPL2 |
![]() |
Gene information | Species | Human | Gene symbol | MRPL2 | Gene ID | 51069 |
Gene name | mitochondrial ribosomal protein L2 | |
Gene Alias | CGI-22 | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | C9IY40 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51069 | MRPL2 | LZE2T | Human | Esophagus | ESCC | 1.12e-08 | 1.74e+00 | 0.082 |
51069 | MRPL2 | LZE4T | Human | Esophagus | ESCC | 4.52e-10 | 2.76e-01 | 0.0811 |
51069 | MRPL2 | LZE5T | Human | Esophagus | ESCC | 1.06e-06 | 2.84e-01 | 0.0514 |
51069 | MRPL2 | LZE7T | Human | Esophagus | ESCC | 2.98e-07 | 5.02e-01 | 0.0667 |
51069 | MRPL2 | LZE8T | Human | Esophagus | ESCC | 4.70e-09 | 1.96e-01 | 0.067 |
51069 | MRPL2 | LZE20T | Human | Esophagus | ESCC | 2.24e-10 | 3.33e-01 | 0.0662 |
51069 | MRPL2 | LZE22D1 | Human | Esophagus | HGIN | 1.11e-05 | 2.30e-01 | 0.0595 |
51069 | MRPL2 | LZE22T | Human | Esophagus | ESCC | 1.38e-02 | 3.35e-01 | 0.068 |
51069 | MRPL2 | LZE24T | Human | Esophagus | ESCC | 4.55e-24 | 6.44e-01 | 0.0596 |
51069 | MRPL2 | LZE6T | Human | Esophagus | ESCC | 4.86e-06 | 5.31e-01 | 0.0845 |
51069 | MRPL2 | P1T-E | Human | Esophagus | ESCC | 1.62e-15 | 6.83e-01 | 0.0875 |
51069 | MRPL2 | P2T-E | Human | Esophagus | ESCC | 2.03e-27 | 6.00e-01 | 0.1177 |
51069 | MRPL2 | P4T-E | Human | Esophagus | ESCC | 1.09e-33 | 9.99e-01 | 0.1323 |
51069 | MRPL2 | P5T-E | Human | Esophagus | ESCC | 3.64e-45 | 8.66e-01 | 0.1327 |
51069 | MRPL2 | P8T-E | Human | Esophagus | ESCC | 1.96e-26 | 5.31e-01 | 0.0889 |
51069 | MRPL2 | P9T-E | Human | Esophagus | ESCC | 2.08e-25 | 6.39e-01 | 0.1131 |
51069 | MRPL2 | P10T-E | Human | Esophagus | ESCC | 4.71e-25 | 4.09e-01 | 0.116 |
51069 | MRPL2 | P11T-E | Human | Esophagus | ESCC | 9.57e-17 | 6.77e-01 | 0.1426 |
51069 | MRPL2 | P12T-E | Human | Esophagus | ESCC | 2.26e-36 | 5.84e-01 | 0.1122 |
51069 | MRPL2 | P15T-E | Human | Esophagus | ESCC | 6.80e-24 | 5.47e-01 | 0.1149 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00226139 | Breast | Precancer | ribonucleoprotein complex biogenesis | 79/1080 | 463/18723 | 2.11e-18 | 1.03e-15 | 79 |
GO:00718269 | Breast | Precancer | ribonucleoprotein complex subunit organization | 48/1080 | 227/18723 | 2.68e-15 | 8.45e-13 | 48 |
GO:00226189 | Breast | Precancer | ribonucleoprotein complex assembly | 47/1080 | 220/18723 | 3.47e-15 | 1.03e-12 | 47 |
GO:00422549 | Breast | Precancer | ribosome biogenesis | 52/1080 | 299/18723 | 7.35e-13 | 1.51e-10 | 52 |
GO:00422559 | Breast | Precancer | ribosome assembly | 21/1080 | 61/18723 | 1.06e-11 | 1.53e-09 | 21 |
GO:00422739 | Breast | Precancer | ribosomal large subunit biogenesis | 22/1080 | 72/18723 | 5.03e-11 | 5.61e-09 | 22 |
GO:00000279 | Breast | Precancer | ribosomal large subunit assembly | 9/1080 | 27/18723 | 1.24e-05 | 3.19e-04 | 9 |
GO:002261314 | Breast | IDC | ribonucleoprotein complex biogenesis | 83/1434 | 463/18723 | 2.01e-13 | 5.20e-11 | 83 |
GO:007182614 | Breast | IDC | ribonucleoprotein complex subunit organization | 52/1434 | 227/18723 | 5.18e-13 | 1.21e-10 | 52 |
GO:002261814 | Breast | IDC | ribonucleoprotein complex assembly | 51/1434 | 220/18723 | 5.32e-13 | 1.21e-10 | 51 |
GO:004225514 | Breast | IDC | ribosome assembly | 21/1434 | 61/18723 | 1.98e-09 | 1.76e-07 | 21 |
GO:004227314 | Breast | IDC | ribosomal large subunit biogenesis | 22/1434 | 72/18723 | 1.04e-08 | 7.67e-07 | 22 |
GO:004225414 | Breast | IDC | ribosome biogenesis | 52/1434 | 299/18723 | 1.90e-08 | 1.32e-06 | 52 |
GO:000002714 | Breast | IDC | ribosomal large subunit assembly | 9/1434 | 27/18723 | 1.17e-04 | 2.17e-03 | 9 |
GO:002261324 | Breast | DCIS | ribonucleoprotein complex biogenesis | 83/1390 | 463/18723 | 3.65e-14 | 1.09e-11 | 83 |
GO:007182624 | Breast | DCIS | ribonucleoprotein complex subunit organization | 52/1390 | 227/18723 | 1.54e-13 | 3.95e-11 | 52 |
GO:002261824 | Breast | DCIS | ribonucleoprotein complex assembly | 51/1390 | 220/18723 | 1.60e-13 | 3.95e-11 | 51 |
GO:004225524 | Breast | DCIS | ribosome assembly | 21/1390 | 61/18723 | 1.13e-09 | 1.14e-07 | 21 |
GO:004227324 | Breast | DCIS | ribosomal large subunit biogenesis | 22/1390 | 72/18723 | 5.88e-09 | 4.82e-07 | 22 |
GO:004225423 | Breast | DCIS | ribosome biogenesis | 52/1390 | 299/18723 | 6.73e-09 | 5.44e-07 | 52 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301039 | Esophagus | HGIN | Ribosome | 108/1383 | 167/8465 | 1.44e-45 | 4.71e-43 | 3.74e-43 | 108 |
hsa03010115 | Esophagus | HGIN | Ribosome | 108/1383 | 167/8465 | 1.44e-45 | 4.71e-43 | 3.74e-43 | 108 |
hsa03010211 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa03010310 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa0301022 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0301032 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0301042 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
hsa0301052 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
hsa0301030 | Oral cavity | OSCC | Ribosome | 128/3704 | 167/8465 | 2.42e-18 | 1.62e-16 | 8.25e-17 | 128 |
hsa03010114 | Oral cavity | OSCC | Ribosome | 128/3704 | 167/8465 | 2.42e-18 | 1.62e-16 | 8.25e-17 | 128 |
hsa03010210 | Oral cavity | LP | Ribosome | 127/2418 | 167/8465 | 1.22e-37 | 4.05e-35 | 2.61e-35 | 127 |
hsa0301038 | Oral cavity | LP | Ribosome | 127/2418 | 167/8465 | 1.22e-37 | 4.05e-35 | 2.61e-35 | 127 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRPL2 | SNV | Missense_Mutation | c.591N>C | p.Glu197Asp | p.E197D | Q5T653 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MRPL2 | SNV | Missense_Mutation | novel | c.544N>G | p.His182Asp | p.H182D | Q5T653 | protein_coding | deleterious(0) | possibly_damaging(0.653) | TCGA-DF-A2KZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MRPL2 | insertion | Frame_Shift_Ins | novel | c.556_557insG | p.Ala186GlyfsTer14 | p.A186Gfs*14 | Q5T653 | protein_coding | TCGA-DF-A2KY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | ||
MRPL2 | SNV | Missense_Mutation | novel | c.422N>C | p.Leu141Pro | p.L141P | Q5T653 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-4R-AA8I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MRPL2 | SNV | Missense_Mutation | c.605N>A | p.Arg202Gln | p.R202Q | Q5T653 | protein_coding | tolerated(0.39) | benign(0.431) | TCGA-BW-A5NO-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
MRPL2 | SNV | Missense_Mutation | novel | c.430N>T | p.Gly144Trp | p.G144W | Q5T653 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-05-4398-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
MRPL2 | SNV | Missense_Mutation | novel | c.220A>T | p.Ile74Phe | p.I74F | Q5T653 | protein_coding | tolerated(0.11) | benign(0.189) | TCGA-55-7281-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
MRPL2 | SNV | Missense_Mutation | novel | c.689N>A | p.Ser230Tyr | p.S230Y | Q5T653 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-22-0944-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MRPL2 | SNV | Missense_Mutation | novel | c.481N>C | p.Asp161His | p.D161H | Q5T653 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-33-AAS8-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPL2 | SNV | Missense_Mutation | rs747813488 | c.778N>A | p.Ala260Thr | p.A260T | Q5T653 | protein_coding | deleterious(0.05) | probably_damaging(0.999) | TCGA-34-2604-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |