Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/MOGAT3_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/MOGAT3_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/MOGAT3_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006066 | Colorectum | AD | alcohol metabolic process | 106/3918 | 353/18723 | 3.02e-05 | 5.57e-04 | 106 |
GO:0044262 | Colorectum | AD | cellular carbohydrate metabolic process | 87/3918 | 283/18723 | 6.00e-05 | 1.01e-03 | 87 |
GO:0045017 | Colorectum | AD | glycerolipid biosynthetic process | 69/3918 | 252/18723 | 8.33e-03 | 4.88e-02 | 69 |
GO:00060661 | Colorectum | SER | alcohol metabolic process | 79/2897 | 353/18723 | 3.50e-04 | 5.50e-03 | 79 |
GO:0046486 | Colorectum | SER | glycerolipid metabolic process | 82/2897 | 392/18723 | 2.26e-03 | 2.17e-02 | 82 |
GO:00450171 | Colorectum | SER | glycerolipid biosynthetic process | 55/2897 | 252/18723 | 4.47e-03 | 3.56e-02 | 55 |
GO:00060662 | Colorectum | MSS | alcohol metabolic process | 92/3467 | 353/18723 | 2.57e-04 | 3.46e-03 | 92 |
GO:00442621 | Colorectum | FAP | cellular carbohydrate metabolic process | 66/2622 | 283/18723 | 1.53e-05 | 4.01e-04 | 66 |
GO:00060663 | Colorectum | FAP | alcohol metabolic process | 69/2622 | 353/18723 | 2.29e-03 | 1.85e-02 | 69 |
GO:00450172 | Colorectum | FAP | glycerolipid biosynthetic process | 50/2622 | 252/18723 | 6.32e-03 | 3.95e-02 | 50 |
GO:0006641 | Stomach | GC | triglyceride metabolic process | 23/1159 | 100/18723 | 3.27e-08 | 2.44e-06 | 23 |
GO:0006639 | Stomach | GC | acylglycerol metabolic process | 24/1159 | 128/18723 | 9.59e-07 | 4.53e-05 | 24 |
GO:0006638 | Stomach | GC | neutral lipid metabolic process | 24/1159 | 129/18723 | 1.11e-06 | 5.20e-05 | 24 |
GO:00060665 | Stomach | GC | alcohol metabolic process | 41/1159 | 353/18723 | 7.85e-05 | 1.68e-03 | 41 |
GO:0006071 | Stomach | GC | glycerol metabolic process | 6/1159 | 19/18723 | 7.49e-04 | 9.67e-03 | 6 |
GO:0046460 | Stomach | GC | neutral lipid biosynthetic process | 10/1159 | 50/18723 | 8.42e-04 | 1.05e-02 | 10 |
GO:0046463 | Stomach | GC | acylglycerol biosynthetic process | 10/1159 | 50/18723 | 8.42e-04 | 1.05e-02 | 10 |
GO:0019432 | Stomach | GC | triglyceride biosynthetic process | 9/1159 | 42/18723 | 9.01e-04 | 1.11e-02 | 9 |
GO:0019400 | Stomach | GC | alditol metabolic process | 6/1159 | 22/18723 | 1.75e-03 | 1.83e-02 | 6 |
GO:00464862 | Stomach | GC | glycerolipid metabolic process | 38/1159 | 392/18723 | 4.15e-03 | 3.47e-02 | 38 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MOGAT3 | SNV | Missense_Mutation | | c.109N>T | p.Gly37Cys | p.G37C | Q86VF5 | protein_coding | deleterious(0) | possibly_damaging(0.751) | TCGA-BG-A0M4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
MOGAT3 | SNV | Missense_Mutation | novel | c.381C>A | p.Phe127Leu | p.F127L | Q86VF5 | protein_coding | deleterious(0) | possibly_damaging(0.895) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MOGAT3 | SNV | Missense_Mutation | | c.524N>C | p.Asp175Ala | p.D175A | Q86VF5 | protein_coding | tolerated(0.05) | benign(0.241) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MOGAT3 | SNV | Missense_Mutation | novel | c.337N>A | p.Ala113Thr | p.A113T | Q86VF5 | protein_coding | tolerated(0.35) | benign(0.013) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
MOGAT3 | SNV | Missense_Mutation | | c.404C>G | p.Ser135Cys | p.S135C | Q86VF5 | protein_coding | deleterious(0.01) | probably_damaging(0.934) | TCGA-E6-A1LZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
MOGAT3 | SNV | Missense_Mutation | rs373510278 | c.808N>T | p.Arg270Cys | p.R270C | Q86VF5 | protein_coding | tolerated(0.16) | benign(0.229) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MOGAT3 | SNV | Missense_Mutation | novel | c.559N>A | p.Val187Met | p.V187M | Q86VF5 | protein_coding | deleterious(0.01) | possibly_damaging(0.696) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MOGAT3 | SNV | Missense_Mutation | | c.388G>A | p.Glu130Lys | p.E130K | Q86VF5 | protein_coding | deleterious(0) | benign(0.164) | TCGA-EY-A1GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MOGAT3 | SNV | Missense_Mutation | novel | c.280N>A | p.Pro94Thr | p.P94T | Q86VF5 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MOGAT3 | SNV | Missense_Mutation | novel | c.512G>A | p.Arg171His | p.R171H | Q86VF5 | protein_coding | tolerated(0.13) | benign(0.019) | TCGA-EY-A549-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |