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Gene: MITD1 |
Gene summary for MITD1 |
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Gene information | Species | Human | Gene symbol | MITD1 | Gene ID | 129531 |
Gene name | microtubule interacting and trafficking domain containing 1 | |
Gene Alias | MITD1 | |
Cytomap | 2q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | Q8WV92 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
129531 | MITD1 | LZE2T | Human | Esophagus | ESCC | 5.39e-04 | 5.82e-01 | 0.082 |
129531 | MITD1 | LZE4T | Human | Esophagus | ESCC | 3.76e-06 | 7.99e-02 | 0.0811 |
129531 | MITD1 | LZE5T | Human | Esophagus | ESCC | 3.58e-08 | 4.02e-01 | 0.0514 |
129531 | MITD1 | LZE7T | Human | Esophagus | ESCC | 5.75e-11 | 3.18e-01 | 0.0667 |
129531 | MITD1 | LZE8T | Human | Esophagus | ESCC | 4.70e-04 | 1.63e-01 | 0.067 |
129531 | MITD1 | LZE20T | Human | Esophagus | ESCC | 2.01e-08 | 1.89e-01 | 0.0662 |
129531 | MITD1 | LZE21D1 | Human | Esophagus | HGIN | 8.61e-03 | 1.50e-01 | 0.0632 |
129531 | MITD1 | LZE22T | Human | Esophagus | ESCC | 3.99e-08 | 4.49e-01 | 0.068 |
129531 | MITD1 | LZE24T | Human | Esophagus | ESCC | 2.22e-12 | 4.16e-01 | 0.0596 |
129531 | MITD1 | LZE6T | Human | Esophagus | ESCC | 2.31e-09 | 1.68e-01 | 0.0845 |
129531 | MITD1 | P1T-E | Human | Esophagus | ESCC | 1.80e-08 | 2.52e-01 | 0.0875 |
129531 | MITD1 | P2T-E | Human | Esophagus | ESCC | 1.35e-20 | 3.04e-01 | 0.1177 |
129531 | MITD1 | P4T-E | Human | Esophagus | ESCC | 3.59e-25 | 5.69e-01 | 0.1323 |
129531 | MITD1 | P5T-E | Human | Esophagus | ESCC | 7.70e-22 | 2.88e-01 | 0.1327 |
129531 | MITD1 | P8T-E | Human | Esophagus | ESCC | 1.31e-19 | 3.50e-01 | 0.0889 |
129531 | MITD1 | P9T-E | Human | Esophagus | ESCC | 9.73e-18 | 4.29e-01 | 0.1131 |
129531 | MITD1 | P10T-E | Human | Esophagus | ESCC | 3.03e-34 | 5.31e-01 | 0.116 |
129531 | MITD1 | P11T-E | Human | Esophagus | ESCC | 6.26e-04 | 3.40e-01 | 0.1426 |
129531 | MITD1 | P12T-E | Human | Esophagus | ESCC | 7.81e-18 | 2.73e-01 | 0.1122 |
129531 | MITD1 | P15T-E | Human | Esophagus | ESCC | 3.79e-27 | 3.07e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000091015 | Esophagus | HGIN | cytokinesis | 44/2587 | 173/18723 | 3.26e-05 | 8.32e-04 | 44 |
GO:005109825 | Esophagus | HGIN | regulation of binding | 78/2587 | 363/18723 | 3.73e-05 | 9.30e-04 | 78 |
GO:00616406 | Esophagus | HGIN | cytoskeleton-dependent cytokinesis | 27/2587 | 100/18723 | 3.71e-04 | 5.77e-03 | 27 |
GO:00619525 | Esophagus | HGIN | midbody abscission | 8/2587 | 17/18723 | 9.96e-04 | 1.25e-02 | 8 |
GO:19024108 | Esophagus | HGIN | mitotic cytokinetic process | 9/2587 | 23/18723 | 2.37e-03 | 2.40e-02 | 9 |
GO:00002816 | Esophagus | HGIN | mitotic cytokinesis | 19/2587 | 71/18723 | 2.90e-03 | 2.81e-02 | 19 |
GO:003209110 | Esophagus | HGIN | negative regulation of protein binding | 23/2587 | 94/18723 | 3.92e-03 | 3.54e-02 | 23 |
GO:005110020 | Esophagus | HGIN | negative regulation of binding | 35/2587 | 162/18723 | 4.32e-03 | 3.84e-02 | 35 |
GO:00325066 | Esophagus | HGIN | cytokinetic process | 12/2587 | 39/18723 | 4.97e-03 | 4.18e-02 | 12 |
GO:0051098111 | Esophagus | ESCC | regulation of binding | 251/8552 | 363/18723 | 6.73e-20 | 8.46e-18 | 251 |
GO:004339320 | Esophagus | ESCC | regulation of protein binding | 135/8552 | 196/18723 | 3.69e-11 | 1.22e-09 | 135 |
GO:000028115 | Esophagus | ESCC | mitotic cytokinesis | 58/8552 | 71/18723 | 4.34e-10 | 1.15e-08 | 58 |
GO:003250614 | Esophagus | ESCC | cytokinetic process | 35/8552 | 39/18723 | 9.38e-09 | 1.90e-07 | 35 |
GO:0051100111 | Esophagus | ESCC | negative regulation of binding | 109/8552 | 162/18723 | 2.10e-08 | 4.03e-07 | 109 |
GO:000091016 | Esophagus | ESCC | cytokinesis | 115/8552 | 173/18723 | 2.48e-08 | 4.68e-07 | 115 |
GO:006164015 | Esophagus | ESCC | cytoskeleton-dependent cytokinesis | 72/8552 | 100/18723 | 8.10e-08 | 1.39e-06 | 72 |
GO:190241014 | Esophagus | ESCC | mitotic cytokinetic process | 22/8552 | 23/18723 | 4.17e-07 | 5.71e-06 | 22 |
GO:006195214 | Esophagus | ESCC | midbody abscission | 17/8552 | 17/18723 | 1.63e-06 | 1.95e-05 | 17 |
GO:003209116 | Esophagus | ESCC | negative regulation of protein binding | 65/8552 | 94/18723 | 3.46e-06 | 3.82e-05 | 65 |
GO:005109812 | Liver | Cirrhotic | regulation of binding | 148/4634 | 363/18723 | 9.14e-12 | 5.97e-10 | 148 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MITD1 | SNV | Missense_Mutation | c.190A>C | p.Lys64Gln | p.K64Q | Q8WV92 | protein_coding | tolerated(0.08) | benign(0.08) | TCGA-HU-A4H0-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
MITD1 | SNV | Missense_Mutation | novel | c.232N>C | p.Tyr78His | p.Y78H | Q8WV92 | protein_coding | tolerated(0.66) | benign(0.003) | TCGA-R5-A7ZI-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MITD1 | insertion | Frame_Shift_Ins | novel | c.743dupA | p.Asn248LysfsTer28 | p.N248Kfs*28 | Q8WV92 | protein_coding | TCGA-B7-5816-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MITD1 | deletion | Frame_Shift_Del | c.723delT | p.His242IlefsTer12 | p.H242Ifs*12 | Q8WV92 | protein_coding | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD | |||
MITD1 | deletion | Frame_Shift_Del | novel | c.321delN | p.Arg108AlafsTer13 | p.R108Afs*13 | Q8WV92 | protein_coding | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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