Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/MICU2_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/MICU2_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/MICU2_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/MICU2_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/MICU2_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000683920 | Esophagus | HGIN | mitochondrial transport | 74/2587 | 254/18723 | 1.32e-10 | 1.32e-08 | 74 |
GO:199054220 | Esophagus | HGIN | mitochondrial transmembrane transport | 29/2587 | 102/18723 | 8.52e-05 | 1.87e-03 | 29 |
GO:0006839110 | Esophagus | ESCC | mitochondrial transport | 187/8552 | 254/18723 | 8.35e-20 | 9.81e-18 | 187 |
GO:1990542110 | Esophagus | ESCC | mitochondrial transmembrane transport | 72/8552 | 102/18723 | 2.94e-07 | 4.23e-06 | 72 |
GO:00515613 | Liver | NAFLD | positive regulation of mitochondrial calcium ion concentration | 5/1882 | 11/18723 | 2.81e-03 | 2.55e-02 | 5 |
GO:00515605 | Liver | NAFLD | mitochondrial calcium ion homeostasis | 8/1882 | 26/18723 | 3.06e-03 | 2.75e-02 | 8 |
GO:00068397 | Liver | Cirrhotic | mitochondrial transport | 112/4634 | 254/18723 | 1.03e-11 | 6.66e-10 | 112 |
GO:005156011 | Liver | Cirrhotic | mitochondrial calcium ion homeostasis | 15/4634 | 26/18723 | 3.43e-04 | 2.93e-03 | 15 |
GO:19905425 | Liver | Cirrhotic | mitochondrial transmembrane transport | 41/4634 | 102/18723 | 4.08e-04 | 3.37e-03 | 41 |
GO:005156111 | Liver | Cirrhotic | positive regulation of mitochondrial calcium ion concentration | 8/4634 | 11/18723 | 1.10e-03 | 7.64e-03 | 8 |
GO:00364444 | Liver | Cirrhotic | calcium import into the mitochondrion | 8/4634 | 14/18723 | 9.65e-03 | 4.35e-02 | 8 |
GO:000683912 | Liver | HCC | mitochondrial transport | 184/7958 | 254/18723 | 2.30e-22 | 3.83e-20 | 184 |
GO:199054212 | Liver | HCC | mitochondrial transmembrane transport | 78/7958 | 102/18723 | 2.73e-12 | 1.26e-10 | 78 |
GO:003644411 | Liver | HCC | calcium import into the mitochondrion | 13/7958 | 14/18723 | 1.25e-04 | 1.03e-03 | 13 |
GO:005156021 | Liver | HCC | mitochondrial calcium ion homeostasis | 20/7958 | 26/18723 | 3.82e-04 | 2.61e-03 | 20 |
GO:00068513 | Liver | HCC | mitochondrial calcium ion transmembrane transport | 16/7958 | 20/18723 | 7.15e-04 | 4.37e-03 | 16 |
GO:00515612 | Liver | HCC | positive regulation of mitochondrial calcium ion concentration | 10/7958 | 11/18723 | 1.30e-03 | 7.01e-03 | 10 |
GO:000683918 | Oral cavity | OSCC | mitochondrial transport | 162/7305 | 254/18723 | 8.96e-16 | 6.52e-14 | 162 |
GO:00515615 | Oral cavity | OSCC | positive regulation of mitochondrial calcium ion concentration | 10/7305 | 11/18723 | 5.78e-04 | 3.30e-03 | 10 |
GO:199054218 | Oral cavity | OSCC | mitochondrial transmembrane transport | 56/7305 | 102/18723 | 8.06e-04 | 4.32e-03 | 56 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MICU2 | SNV | Missense_Mutation | novel | c.231N>G | p.Ile77Met | p.I77M | Q8IYU8 | protein_coding | tolerated(0.12) | benign(0) | TCGA-E6-A2P9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MICU2 | SNV | Missense_Mutation | novel | c.644N>A | p.Thr215Asn | p.T215N | Q8IYU8 | protein_coding | tolerated(0.44) | benign(0.031) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MICU2 | SNV | Missense_Mutation | novel | c.493N>G | p.Phe165Val | p.F165V | Q8IYU8 | protein_coding | deleterious(0) | possibly_damaging(0.884) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
MICU2 | SNV | Missense_Mutation | | c.450N>T | p.Arg150Ser | p.R150S | Q8IYU8 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD |
MICU2 | SNV | Missense_Mutation | rs762263379 | c.893N>C | p.Ile298Thr | p.I298T | Q8IYU8 | protein_coding | tolerated(0.34) | benign(0.026) | TCGA-UB-A7MF-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
MICU2 | SNV | Missense_Mutation | novel | c.346N>C | p.Glu116Gln | p.E116Q | Q8IYU8 | protein_coding | tolerated(0.26) | possibly_damaging(0.522) | TCGA-05-5428-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
MICU2 | SNV | Missense_Mutation | novel | c.1055N>T | p.Arg352Ile | p.R352I | Q8IYU8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-95-A4VN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MICU2 | SNV | Missense_Mutation | novel | c.1034N>C | p.Val345Ala | p.V345A | Q8IYU8 | protein_coding | deleterious(0) | possibly_damaging(0.551) | TCGA-22-4609-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MICU2 | SNV | Missense_Mutation | novel | c.1047N>T | p.Glu349Asp | p.E349D | Q8IYU8 | protein_coding | deleterious(0.02) | possibly_damaging(0.891) | TCGA-85-8582-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MICU2 | SNV | Missense_Mutation | novel | c.1181N>C | p.Arg394Thr | p.R394T | Q8IYU8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-NC-A5HI-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |