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Gene: MIB1 |
Gene summary for MIB1 |
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Gene information | Species | Human | Gene symbol | MIB1 | Gene ID | 57534 |
Gene name | MIB E3 ubiquitin protein ligase 1 | |
Gene Alias | DIP-1 | |
Cytomap | 18q11.2 | |
Gene Type | protein-coding | GO ID | GO:0001568 | UniProtAcc | Q86YT6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57534 | MIB1 | CCI_1 | Human | Cervix | CC | 5.76e-04 | 7.41e-01 | 0.528 |
57534 | MIB1 | LZE2T | Human | Esophagus | ESCC | 2.76e-02 | 3.26e-01 | 0.082 |
57534 | MIB1 | LZE4T | Human | Esophagus | ESCC | 3.23e-05 | 1.03e-01 | 0.0811 |
57534 | MIB1 | LZE7T | Human | Esophagus | ESCC | 2.63e-02 | 4.17e-01 | 0.0667 |
57534 | MIB1 | LZE22T | Human | Esophagus | ESCC | 4.29e-02 | 2.19e-01 | 0.068 |
57534 | MIB1 | LZE24T | Human | Esophagus | ESCC | 1.48e-07 | 2.28e-01 | 0.0596 |
57534 | MIB1 | P2T-E | Human | Esophagus | ESCC | 2.31e-19 | 4.44e-01 | 0.1177 |
57534 | MIB1 | P4T-E | Human | Esophagus | ESCC | 3.61e-14 | 2.80e-01 | 0.1323 |
57534 | MIB1 | P5T-E | Human | Esophagus | ESCC | 8.02e-10 | 9.54e-02 | 0.1327 |
57534 | MIB1 | P8T-E | Human | Esophagus | ESCC | 8.63e-10 | 2.42e-01 | 0.0889 |
57534 | MIB1 | P9T-E | Human | Esophagus | ESCC | 3.85e-08 | 2.31e-01 | 0.1131 |
57534 | MIB1 | P10T-E | Human | Esophagus | ESCC | 1.44e-13 | 2.42e-01 | 0.116 |
57534 | MIB1 | P11T-E | Human | Esophagus | ESCC | 2.35e-06 | 2.05e-01 | 0.1426 |
57534 | MIB1 | P12T-E | Human | Esophagus | ESCC | 1.09e-12 | 3.55e-01 | 0.1122 |
57534 | MIB1 | P15T-E | Human | Esophagus | ESCC | 4.47e-10 | 1.90e-01 | 0.1149 |
57534 | MIB1 | P16T-E | Human | Esophagus | ESCC | 7.18e-12 | 1.63e-01 | 0.1153 |
57534 | MIB1 | P17T-E | Human | Esophagus | ESCC | 1.09e-04 | 8.49e-02 | 0.1278 |
57534 | MIB1 | P19T-E | Human | Esophagus | ESCC | 2.15e-02 | 1.93e-01 | 0.1662 |
57534 | MIB1 | P20T-E | Human | Esophagus | ESCC | 3.16e-02 | 2.52e-02 | 0.1124 |
57534 | MIB1 | P21T-E | Human | Esophagus | ESCC | 7.42e-07 | 1.30e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00301008 | Cervix | CC | regulation of endocytosis | 47/2311 | 211/18723 | 3.65e-05 | 5.82e-04 | 47 |
GO:00458077 | Cervix | CC | positive regulation of endocytosis | 27/2311 | 100/18723 | 5.55e-05 | 8.10e-04 | 27 |
GO:00017018 | Cervix | CC | in utero embryonic development | 71/2311 | 367/18723 | 7.21e-05 | 1.00e-03 | 71 |
GO:00072194 | Cervix | CC | Notch signaling pathway | 39/2311 | 172/18723 | 1.08e-04 | 1.38e-03 | 39 |
GO:00351487 | Cervix | CC | tube formation | 31/2311 | 148/18723 | 2.07e-03 | 1.51e-02 | 31 |
GO:00018417 | Cervix | CC | neural tube formation | 23/2311 | 102/18723 | 2.80e-03 | 1.87e-02 | 23 |
GO:00605626 | Cervix | CC | epithelial tube morphogenesis | 57/2311 | 325/18723 | 3.79e-03 | 2.41e-02 | 57 |
GO:00219156 | Cervix | CC | neural tube development | 30/2311 | 152/18723 | 6.00e-03 | 3.43e-02 | 30 |
GO:0045665 | Cervix | CC | negative regulation of neuron differentiation | 16/2311 | 69/18723 | 8.75e-03 | 4.48e-02 | 16 |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:000184115 | Esophagus | ESCC | neural tube formation | 75/8552 | 102/18723 | 9.68e-09 | 1.95e-07 | 75 |
GO:003010018 | Esophagus | ESCC | regulation of endocytosis | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
GO:00219159 | Esophagus | ESCC | neural tube development | 101/8552 | 152/18723 | 1.78e-07 | 2.79e-06 | 101 |
GO:00163316 | Esophagus | ESCC | morphogenesis of embryonic epithelium | 98/8552 | 147/18723 | 2.12e-07 | 3.27e-06 | 98 |
GO:000183814 | Esophagus | ESCC | embryonic epithelial tube formation | 83/8552 | 121/18723 | 2.78e-07 | 4.08e-06 | 83 |
GO:003514815 | Esophagus | ESCC | tube formation | 96/8552 | 148/18723 | 1.86e-06 | 2.16e-05 | 96 |
GO:004580718 | Esophagus | ESCC | positive regulation of endocytosis | 69/8552 | 100/18723 | 1.97e-06 | 2.29e-05 | 69 |
GO:00721759 | Esophagus | ESCC | epithelial tube formation | 86/8552 | 132/18723 | 4.81e-06 | 5.10e-05 | 86 |
GO:006056210 | Esophagus | ESCC | epithelial tube morphogenesis | 187/8552 | 325/18723 | 9.95e-06 | 9.44e-05 | 187 |
GO:00072197 | Esophagus | ESCC | Notch signaling pathway | 106/8552 | 172/18723 | 1.74e-05 | 1.55e-04 | 106 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0541720 | Cervix | CC | Lipid and atherosclerosis | 65/1267 | 215/8465 | 6.47e-09 | 1.10e-07 | 6.52e-08 | 65 |
hsa05417110 | Cervix | CC | Lipid and atherosclerosis | 65/1267 | 215/8465 | 6.47e-09 | 1.10e-07 | 6.52e-08 | 65 |
hsa05417211 | Esophagus | ESCC | Lipid and atherosclerosis | 143/4205 | 215/8465 | 3.30e-07 | 2.45e-06 | 1.26e-06 | 143 |
hsa05417310 | Esophagus | ESCC | Lipid and atherosclerosis | 143/4205 | 215/8465 | 3.30e-07 | 2.45e-06 | 1.26e-06 | 143 |
hsa0541722 | Liver | Cirrhotic | Lipid and atherosclerosis | 80/2530 | 215/8465 | 1.18e-02 | 3.81e-02 | 2.35e-02 | 80 |
hsa0541732 | Liver | Cirrhotic | Lipid and atherosclerosis | 80/2530 | 215/8465 | 1.18e-02 | 3.81e-02 | 2.35e-02 | 80 |
hsa0541742 | Liver | HCC | Lipid and atherosclerosis | 118/4020 | 215/8465 | 1.66e-02 | 3.92e-02 | 2.18e-02 | 118 |
hsa0541752 | Liver | HCC | Lipid and atherosclerosis | 118/4020 | 215/8465 | 1.66e-02 | 3.92e-02 | 2.18e-02 | 118 |
hsa0541728 | Prostate | BPH | Lipid and atherosclerosis | 66/1718 | 215/8465 | 1.68e-04 | 9.56e-04 | 5.92e-04 | 66 |
hsa05417112 | Prostate | BPH | Lipid and atherosclerosis | 66/1718 | 215/8465 | 1.68e-04 | 9.56e-04 | 5.92e-04 | 66 |
hsa0541729 | Prostate | Tumor | Lipid and atherosclerosis | 65/1791 | 215/8465 | 9.79e-04 | 4.44e-03 | 2.75e-03 | 65 |
hsa0541737 | Prostate | Tumor | Lipid and atherosclerosis | 65/1791 | 215/8465 | 9.79e-04 | 4.44e-03 | 2.75e-03 | 65 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MIB1 | SNV | Missense_Mutation | c.2434N>T | p.Asp812Tyr | p.D812Y | Q86YT6 | protein_coding | tolerated(0.65) | probably_damaging(0.969) | TCGA-AG-3883-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MIB1 | SNV | Missense_Mutation | novel | c.775G>A | p.Glu259Lys | p.E259K | Q86YT6 | protein_coding | deleterious(0.01) | possibly_damaging(0.692) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MIB1 | SNV | Missense_Mutation | novel | c.2522C>A | p.Ser841Tyr | p.S841Y | Q86YT6 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MIB1 | SNV | Missense_Mutation | novel | c.1193N>T | p.Ser398Phe | p.S398F | Q86YT6 | protein_coding | deleterious(0) | benign(0.058) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
MIB1 | SNV | Missense_Mutation | c.1702N>A | p.His568Asn | p.H568N | Q86YT6 | protein_coding | deleterious(0) | benign(0.085) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
MIB1 | SNV | Missense_Mutation | rs746365974 | c.953N>A | p.Arg318Gln | p.R318Q | Q86YT6 | protein_coding | tolerated(0.62) | possibly_damaging(0.614) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MIB1 | SNV | Missense_Mutation | novel | c.1076C>T | p.Ala359Val | p.A359V | Q86YT6 | protein_coding | tolerated(0.1) | possibly_damaging(0.878) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MIB1 | SNV | Missense_Mutation | c.1627C>A | p.Leu543Ile | p.L543I | Q86YT6 | protein_coding | tolerated(0.47) | probably_damaging(0.92) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
MIB1 | SNV | Missense_Mutation | novel | c.1781A>G | p.Asn594Ser | p.N594S | Q86YT6 | protein_coding | tolerated(0.12) | probably_damaging(0.973) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MIB1 | SNV | Missense_Mutation | rs750577728 | c.389N>T | p.Pro130Leu | p.P130L | Q86YT6 | protein_coding | deleterious(0) | probably_damaging(0.931) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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