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Gene: MED1 |
Gene summary for MED1 |
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Gene information | Species | Human | Gene symbol | MED1 | Gene ID | 5469 |
Gene name | mediator complex subunit 1 | |
Gene Alias | CRSP1 | |
Cytomap | 17q12 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q15648 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5469 | MED1 | GSM4909291 | Human | Breast | IDC | 2.79e-50 | 1.04e+00 | 0.1753 |
5469 | MED1 | GSM4909292 | Human | Breast | IDC | 2.16e-03 | 4.18e-01 | 0.1236 |
5469 | MED1 | GSM4909293 | Human | Breast | IDC | 1.82e-56 | 8.34e-01 | 0.1581 |
5469 | MED1 | GSM4909317 | Human | Breast | IDC | 2.82e-02 | 1.51e-01 | 0.1355 |
5469 | MED1 | DCIS2 | Human | Breast | DCIS | 2.67e-20 | 8.42e-02 | 0.0085 |
5469 | MED1 | LZE2T | Human | Esophagus | ESCC | 1.06e-02 | 2.93e-01 | 0.082 |
5469 | MED1 | LZE4T | Human | Esophagus | ESCC | 3.44e-08 | 2.66e-01 | 0.0811 |
5469 | MED1 | LZE5T | Human | Esophagus | ESCC | 3.23e-07 | 3.71e-01 | 0.0514 |
5469 | MED1 | LZE7T | Human | Esophagus | ESCC | 1.35e-09 | 4.22e-01 | 0.0667 |
5469 | MED1 | LZE8T | Human | Esophagus | ESCC | 1.06e-02 | 1.75e-01 | 0.067 |
5469 | MED1 | LZE22T | Human | Esophagus | ESCC | 3.41e-03 | 1.82e-01 | 0.068 |
5469 | MED1 | LZE24T | Human | Esophagus | ESCC | 3.13e-17 | 4.21e-01 | 0.0596 |
5469 | MED1 | LZE21T | Human | Esophagus | ESCC | 8.40e-03 | 1.84e-01 | 0.0655 |
5469 | MED1 | P1T-E | Human | Esophagus | ESCC | 2.31e-06 | 2.79e-01 | 0.0875 |
5469 | MED1 | P2T-E | Human | Esophagus | ESCC | 1.92e-17 | 3.23e-01 | 0.1177 |
5469 | MED1 | P4T-E | Human | Esophagus | ESCC | 2.12e-16 | 3.12e-01 | 0.1323 |
5469 | MED1 | P5T-E | Human | Esophagus | ESCC | 9.36e-08 | 1.65e-01 | 0.1327 |
5469 | MED1 | P8T-E | Human | Esophagus | ESCC | 9.37e-19 | 3.74e-01 | 0.0889 |
5469 | MED1 | P9T-E | Human | Esophagus | ESCC | 1.82e-10 | 2.21e-01 | 0.1131 |
5469 | MED1 | P10T-E | Human | Esophagus | ESCC | 7.15e-07 | 1.64e-01 | 0.116 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00525479 | Breast | Precancer | regulation of peptidase activity | 71/1080 | 461/18723 | 2.72e-14 | 6.94e-12 | 71 |
GO:00525489 | Breast | Precancer | regulation of endopeptidase activity | 67/1080 | 432/18723 | 1.06e-13 | 2.36e-11 | 67 |
GO:00458619 | Breast | Precancer | negative regulation of proteolysis | 50/1080 | 351/18723 | 2.99e-09 | 2.39e-07 | 50 |
GO:00513468 | Breast | Precancer | negative regulation of hydrolase activity | 50/1080 | 379/18723 | 3.85e-08 | 2.34e-06 | 50 |
GO:00104668 | Breast | Precancer | negative regulation of peptidase activity | 38/1080 | 262/18723 | 1.46e-07 | 7.82e-06 | 38 |
GO:00109519 | Breast | Precancer | negative regulation of endopeptidase activity | 37/1080 | 252/18723 | 1.55e-07 | 8.05e-06 | 37 |
GO:00018196 | Breast | Precancer | positive regulation of cytokine production | 52/1080 | 467/18723 | 4.18e-06 | 1.29e-04 | 52 |
GO:19049519 | Breast | Precancer | positive regulation of establishment of protein localization | 36/1080 | 319/18723 | 9.30e-05 | 1.75e-03 | 36 |
GO:00069009 | Breast | Precancer | vesicle budding from membrane | 12/1080 | 61/18723 | 1.61e-04 | 2.69e-03 | 12 |
GO:00512229 | Breast | Precancer | positive regulation of protein transport | 31/1080 | 303/18723 | 1.44e-03 | 1.50e-02 | 31 |
GO:00507086 | Breast | Precancer | regulation of protein secretion | 28/1080 | 268/18723 | 1.76e-03 | 1.74e-02 | 28 |
GO:00718064 | Breast | Precancer | protein transmembrane transport | 10/1080 | 59/18723 | 1.86e-03 | 1.81e-02 | 10 |
GO:0032732 | Breast | Precancer | positive regulation of interleukin-1 production | 11/1080 | 73/18723 | 2.96e-03 | 2.55e-02 | 11 |
GO:00716926 | Breast | Precancer | protein localization to extracellular region | 34/1080 | 368/18723 | 4.65e-03 | 3.58e-02 | 34 |
GO:00093067 | Breast | Precancer | protein secretion | 33/1080 | 359/18723 | 5.65e-03 | 4.08e-02 | 33 |
GO:00355927 | Breast | Precancer | establishment of protein localization to extracellular region | 33/1080 | 360/18723 | 5.89e-03 | 4.21e-02 | 33 |
GO:00481992 | Breast | Precancer | vesicle targeting, to, from or within Golgi | 5/1080 | 21/18723 | 5.93e-03 | 4.21e-02 | 5 |
GO:005254714 | Breast | IDC | regulation of peptidase activity | 96/1434 | 461/18723 | 7.58e-20 | 6.15e-17 | 96 |
GO:005254814 | Breast | IDC | regulation of endopeptidase activity | 88/1434 | 432/18723 | 1.20e-17 | 4.85e-15 | 88 |
GO:004854514 | Breast | IDC | response to steroid hormone | 70/1434 | 339/18723 | 1.34e-14 | 4.23e-12 | 70 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0491916 | Breast | IDC | Thyroid hormone signaling pathway | 23/867 | 121/8465 | 2.45e-03 | 1.69e-02 | 1.27e-02 | 23 |
hsa0491917 | Breast | IDC | Thyroid hormone signaling pathway | 23/867 | 121/8465 | 2.45e-03 | 1.69e-02 | 1.27e-02 | 23 |
hsa0491928 | Esophagus | ESCC | Thyroid hormone signaling pathway | 78/4205 | 121/8465 | 6.79e-04 | 2.23e-03 | 1.14e-03 | 78 |
hsa015227 | Esophagus | ESCC | Endocrine resistance | 63/4205 | 98/8465 | 2.38e-03 | 6.58e-03 | 3.37e-03 | 63 |
hsa04919113 | Esophagus | ESCC | Thyroid hormone signaling pathway | 78/4205 | 121/8465 | 6.79e-04 | 2.23e-03 | 1.14e-03 | 78 |
hsa0152215 | Esophagus | ESCC | Endocrine resistance | 63/4205 | 98/8465 | 2.38e-03 | 6.58e-03 | 3.37e-03 | 63 |
hsa0491912 | Liver | HCC | Thyroid hormone signaling pathway | 75/4020 | 121/8465 | 8.76e-04 | 3.38e-03 | 1.88e-03 | 75 |
hsa01522 | Liver | HCC | Endocrine resistance | 58/4020 | 98/8465 | 1.28e-02 | 3.19e-02 | 1.78e-02 | 58 |
hsa0491913 | Liver | HCC | Thyroid hormone signaling pathway | 75/4020 | 121/8465 | 8.76e-04 | 3.38e-03 | 1.88e-03 | 75 |
hsa015221 | Liver | HCC | Endocrine resistance | 58/4020 | 98/8465 | 1.28e-02 | 3.19e-02 | 1.78e-02 | 58 |
hsa015226 | Oral cavity | OSCC | Endocrine resistance | 63/3704 | 98/8465 | 3.09e-05 | 1.31e-04 | 6.67e-05 | 63 |
hsa0491926 | Oral cavity | OSCC | Thyroid hormone signaling pathway | 73/3704 | 121/8465 | 1.63e-04 | 5.52e-04 | 2.81e-04 | 73 |
hsa0152214 | Oral cavity | OSCC | Endocrine resistance | 63/3704 | 98/8465 | 3.09e-05 | 1.31e-04 | 6.67e-05 | 63 |
hsa04919112 | Oral cavity | OSCC | Thyroid hormone signaling pathway | 73/3704 | 121/8465 | 1.63e-04 | 5.52e-04 | 2.81e-04 | 73 |
hsa0152221 | Prostate | Tumor | Endocrine resistance | 37/1791 | 98/8465 | 1.17e-04 | 7.42e-04 | 4.60e-04 | 37 |
hsa0491925 | Prostate | Tumor | Thyroid hormone signaling pathway | 40/1791 | 121/8465 | 1.47e-03 | 6.26e-03 | 3.88e-03 | 40 |
hsa0152231 | Prostate | Tumor | Endocrine resistance | 37/1791 | 98/8465 | 1.17e-04 | 7.42e-04 | 4.60e-04 | 37 |
hsa0491934 | Prostate | Tumor | Thyroid hormone signaling pathway | 40/1791 | 121/8465 | 1.47e-03 | 6.26e-03 | 3.88e-03 | 40 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MED1 | insertion | Frame_Shift_Ins | novel | c.4572_4573insA | p.Ser1525IlefsTer3 | p.S1525Ifs*3 | Q15648 | protein_coding | TCGA-EK-A2RE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
MED1 | SNV | Missense_Mutation | novel | c.1931N>C | p.Met644Thr | p.M644T | Q15648 | protein_coding | deleterious_low_confidence(0) | benign(0.052) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
MED1 | SNV | Missense_Mutation | c.2750N>C | p.Glu917Ala | p.E917A | Q15648 | protein_coding | deleterious_low_confidence(0.01) | benign(0.069) | TCGA-A6-5667-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
MED1 | SNV | Missense_Mutation | c.68N>A | p.Leu23His | p.L23H | Q15648 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
MED1 | SNV | Missense_Mutation | c.1423G>A | p.Val475Met | p.V475M | Q15648 | protein_coding | deleterious(0.01) | possibly_damaging(0.809) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MED1 | SNV | Missense_Mutation | novel | c.3839N>A | p.Met1280Lys | p.M1280K | Q15648 | protein_coding | tolerated_low_confidence(0.18) | benign(0.018) | TCGA-AA-3852-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MED1 | SNV | Missense_Mutation | c.1592N>T | p.Thr531Ile | p.T531I | Q15648 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AA-3852-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
MED1 | SNV | Missense_Mutation | novel | c.1568C>A | p.Pro523Gln | p.P523Q | Q15648 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MED1 | SNV | Missense_Mutation | c.3502N>C | p.Ser1168Arg | p.S1168R | Q15648 | protein_coding | tolerated_low_confidence(0.06) | benign(0.039) | TCGA-AA-3952-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
MED1 | SNV | Missense_Mutation | novel | c.2057N>C | p.Lys686Thr | p.K686T | Q15648 | protein_coding | tolerated_low_confidence(0.09) | benign(0) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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