![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MCF2L2 |
Gene summary for MCF2L2 |
![]() |
Gene information | Species | Human | Gene symbol | MCF2L2 | Gene ID | 23101 |
Gene name | MCF.2 cell line derived transforming sequence-like 2 | |
Gene Alias | ARHGEF22 | |
Cytomap | 3q27.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q86YR7 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23101 | MCF2L2 | CCI_1 | Human | Cervix | CC | 9.95e-07 | 4.69e-01 | 0.528 |
23101 | MCF2L2 | CCI_2 | Human | Cervix | CC | 2.15e-06 | 5.00e-01 | 0.5249 |
23101 | MCF2L2 | CCI_3 | Human | Cervix | CC | 3.98e-05 | 3.21e-01 | 0.516 |
23101 | MCF2L2 | LZE4T | Human | Esophagus | ESCC | 1.04e-04 | 2.03e-01 | 0.0811 |
23101 | MCF2L2 | LZE24T | Human | Esophagus | ESCC | 4.14e-03 | 1.61e-01 | 0.0596 |
23101 | MCF2L2 | P9T-E | Human | Esophagus | ESCC | 1.31e-05 | 1.12e-01 | 0.1131 |
23101 | MCF2L2 | P12T-E | Human | Esophagus | ESCC | 5.68e-24 | 5.20e-01 | 0.1122 |
23101 | MCF2L2 | P15T-E | Human | Esophagus | ESCC | 7.93e-03 | 1.01e-01 | 0.1149 |
23101 | MCF2L2 | P20T-E | Human | Esophagus | ESCC | 3.50e-02 | 7.20e-02 | 0.1124 |
23101 | MCF2L2 | P21T-E | Human | Esophagus | ESCC | 3.50e-02 | 8.86e-02 | 0.1617 |
23101 | MCF2L2 | P22T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.05e-01 | 0.1236 |
23101 | MCF2L2 | P23T-E | Human | Esophagus | ESCC | 1.06e-09 | 2.94e-01 | 0.108 |
23101 | MCF2L2 | P26T-E | Human | Esophagus | ESCC | 5.87e-84 | 1.51e+00 | 0.1276 |
23101 | MCF2L2 | P28T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.30e-01 | 0.1149 |
23101 | MCF2L2 | P30T-E | Human | Esophagus | ESCC | 2.98e-03 | 2.19e-01 | 0.137 |
23101 | MCF2L2 | P39T-E | Human | Esophagus | ESCC | 4.41e-07 | 1.48e-01 | 0.0894 |
23101 | MCF2L2 | P40T-E | Human | Esophagus | ESCC | 1.33e-02 | 8.98e-02 | 0.109 |
23101 | MCF2L2 | P42T-E | Human | Esophagus | ESCC | 6.89e-06 | 1.08e-01 | 0.1175 |
23101 | MCF2L2 | P47T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.38e-01 | 0.1067 |
23101 | MCF2L2 | P48T-E | Human | Esophagus | ESCC | 4.17e-05 | 8.36e-02 | 0.0959 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MCF2L2 | SNV | Missense_Mutation | c.2777N>A | p.Arg926Gln | p.R926Q | Q86YR7 | protein_coding | tolerated(0.18) | benign(0) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MCF2L2 | SNV | Missense_Mutation | c.1418N>A | p.Gly473Asp | p.G473D | Q86YR7 | protein_coding | tolerated(0.45) | benign(0.001) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
MCF2L2 | SNV | Missense_Mutation | c.1789N>G | p.Phe597Val | p.F597V | Q86YR7 | protein_coding | tolerated(0.51) | benign(0) | TCGA-AA-A02Y-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MCF2L2 | SNV | Missense_Mutation | c.1310N>A | p.Ser437Asn | p.S437N | Q86YR7 | protein_coding | tolerated(0.38) | benign(0.031) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
MCF2L2 | SNV | Missense_Mutation | novel | c.182N>T | p.Ala61Val | p.A61V | Q86YR7 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
MCF2L2 | SNV | Missense_Mutation | rs537201516 | c.406N>T | p.Arg136Cys | p.R136C | Q86YR7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
MCF2L2 | SNV | Missense_Mutation | rs529572628 | c.209N>T | p.Ser70Leu | p.S70L | Q86YR7 | protein_coding | tolerated(0.19) | benign(0.025) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
MCF2L2 | SNV | Missense_Mutation | c.2924N>A | p.Gly975Asp | p.G975D | Q86YR7 | protein_coding | tolerated(0.36) | benign(0.001) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
MCF2L2 | SNV | Missense_Mutation | c.2032N>A | p.Glu678Lys | p.E678K | Q86YR7 | protein_coding | deleterious(0.02) | probably_damaging(0.913) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
MCF2L2 | SNV | Missense_Mutation | rs773032244 | c.181N>A | p.Ala61Thr | p.A61T | Q86YR7 | protein_coding | deleterious(0.03) | probably_damaging(0.986) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |