![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MBD6 |
Gene summary for MBD6 |
![]() |
Gene information | Species | Human | Gene symbol | MBD6 | Gene ID | 114785 |
Gene name | methyl-CpG binding domain protein 6 | |
Gene Alias | MBD6 | |
Cytomap | 12q13.3 | |
Gene Type | protein-coding | GO ID | GO:0001650 | UniProtAcc | A0A024RBA3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114785 | MBD6 | LZE4T | Human | Esophagus | ESCC | 6.22e-05 | 6.44e-02 | 0.0811 |
114785 | MBD6 | LZE8T | Human | Esophagus | ESCC | 1.44e-03 | 1.05e-01 | 0.067 |
114785 | MBD6 | LZE22D1 | Human | Esophagus | HGIN | 6.76e-03 | 1.09e-01 | 0.0595 |
114785 | MBD6 | LZE24T | Human | Esophagus | ESCC | 1.97e-13 | 3.22e-01 | 0.0596 |
114785 | MBD6 | P1T-E | Human | Esophagus | ESCC | 9.61e-14 | 5.00e-01 | 0.0875 |
114785 | MBD6 | P2T-E | Human | Esophagus | ESCC | 5.45e-35 | 5.82e-01 | 0.1177 |
114785 | MBD6 | P4T-E | Human | Esophagus | ESCC | 9.38e-13 | 1.63e-01 | 0.1323 |
114785 | MBD6 | P5T-E | Human | Esophagus | ESCC | 3.20e-06 | 7.83e-02 | 0.1327 |
114785 | MBD6 | P8T-E | Human | Esophagus | ESCC | 3.67e-37 | 6.07e-01 | 0.0889 |
114785 | MBD6 | P9T-E | Human | Esophagus | ESCC | 1.51e-04 | 6.07e-02 | 0.1131 |
114785 | MBD6 | P10T-E | Human | Esophagus | ESCC | 2.74e-10 | 2.24e-01 | 0.116 |
114785 | MBD6 | P11T-E | Human | Esophagus | ESCC | 1.95e-11 | 3.74e-01 | 0.1426 |
114785 | MBD6 | P12T-E | Human | Esophagus | ESCC | 1.84e-25 | 3.90e-01 | 0.1122 |
114785 | MBD6 | P15T-E | Human | Esophagus | ESCC | 5.62e-12 | 3.53e-01 | 0.1149 |
114785 | MBD6 | P16T-E | Human | Esophagus | ESCC | 1.04e-17 | 3.34e-01 | 0.1153 |
114785 | MBD6 | P17T-E | Human | Esophagus | ESCC | 3.01e-03 | 2.87e-01 | 0.1278 |
114785 | MBD6 | P19T-E | Human | Esophagus | ESCC | 8.52e-03 | 1.86e-01 | 0.1662 |
114785 | MBD6 | P20T-E | Human | Esophagus | ESCC | 7.06e-17 | 4.33e-01 | 0.1124 |
114785 | MBD6 | P21T-E | Human | Esophagus | ESCC | 5.68e-15 | 1.95e-01 | 0.1617 |
114785 | MBD6 | P22T-E | Human | Esophagus | ESCC | 1.27e-16 | 1.05e-01 | 0.1236 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MBD6 | SNV | Missense_Mutation | rs374027869 | c.2828C>T | p.Pro943Leu | p.P943L | Q96DN6 | protein_coding | tolerated_low_confidence(0.07) | benign(0) | TCGA-AA-3841-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
MBD6 | SNV | Missense_Mutation | c.2342N>A | p.Gly781Glu | p.G781E | Q96DN6 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.948) | TCGA-AA-3848-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
MBD6 | SNV | Missense_Mutation | c.1397N>A | p.Ser466Asn | p.S466N | Q96DN6 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.916) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
MBD6 | SNV | Missense_Mutation | c.2155N>A | p.Ala719Thr | p.A719T | Q96DN6 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.719) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
MBD6 | SNV | Missense_Mutation | novel | c.2593N>T | p.Leu865Phe | p.L865F | Q96DN6 | protein_coding | tolerated_low_confidence(0.43) | possibly_damaging(0.461) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
MBD6 | SNV | Missense_Mutation | rs756453796 | c.1100N>A | p.Arg367His | p.R367H | Q96DN6 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.967) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
MBD6 | SNV | Missense_Mutation | novel | c.2458N>C | p.Ser820Pro | p.S820P | Q96DN6 | protein_coding | tolerated_low_confidence(0.49) | benign(0.003) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
MBD6 | SNV | Missense_Mutation | c.2018N>G | p.Leu673Arg | p.L673R | Q96DN6 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.918) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MBD6 | SNV | Missense_Mutation | novel | c.1985N>A | p.Leu662Gln | p.L662Q | Q96DN6 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.873) | TCGA-AY-4070-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD |
MBD6 | SNV | Missense_Mutation | c.2335N>T | p.Pro779Ser | p.P779S | Q96DN6 | protein_coding | deleterious_low_confidence(0.04) | probably_damaging(0.986) | TCGA-AZ-6608-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |