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Gene: MARK2 |
Gene summary for MARK2 |
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Gene information | Species | Human | Gene symbol | MARK2 | Gene ID | 2011 |
Gene name | microtubule affinity regulating kinase 2 | |
Gene Alias | EMK-1 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q7KZI7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2011 | MARK2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.23e-03 | -3.02e-01 | 0.0155 |
2011 | MARK2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.13e-02 | -6.04e-01 | 0.0216 |
2011 | MARK2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.35e-04 | 3.86e-01 | -0.1954 |
2011 | MARK2 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.99e-02 | 7.08e-01 | -0.2602 |
2011 | MARK2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.18e-08 | -3.25e-01 | 0.294 |
2011 | MARK2 | A002-C-010 | Human | Colorectum | FAP | 3.76e-02 | -2.31e-01 | 0.242 |
2011 | MARK2 | A015-C-203 | Human | Colorectum | FAP | 9.59e-26 | -3.69e-01 | -0.1294 |
2011 | MARK2 | A015-C-204 | Human | Colorectum | FAP | 4.99e-06 | -3.54e-01 | -0.0228 |
2011 | MARK2 | A014-C-040 | Human | Colorectum | FAP | 1.26e-02 | -4.15e-01 | -0.1184 |
2011 | MARK2 | A002-C-201 | Human | Colorectum | FAP | 3.54e-08 | -2.95e-01 | 0.0324 |
2011 | MARK2 | A002-C-203 | Human | Colorectum | FAP | 2.71e-04 | -1.91e-01 | 0.2786 |
2011 | MARK2 | A001-C-119 | Human | Colorectum | FAP | 1.00e-03 | -2.80e-01 | -0.1557 |
2011 | MARK2 | A001-C-108 | Human | Colorectum | FAP | 3.21e-16 | -3.24e-01 | -0.0272 |
2011 | MARK2 | A002-C-205 | Human | Colorectum | FAP | 4.03e-16 | -4.09e-01 | -0.1236 |
2011 | MARK2 | A001-C-104 | Human | Colorectum | FAP | 3.90e-06 | -2.25e-01 | 0.0184 |
2011 | MARK2 | A015-C-005 | Human | Colorectum | FAP | 2.53e-05 | -3.62e-01 | -0.0336 |
2011 | MARK2 | A015-C-006 | Human | Colorectum | FAP | 5.18e-08 | -2.55e-01 | -0.0994 |
2011 | MARK2 | A015-C-106 | Human | Colorectum | FAP | 4.33e-15 | -2.22e-01 | -0.0511 |
2011 | MARK2 | A002-C-114 | Human | Colorectum | FAP | 1.13e-12 | -3.80e-01 | -0.1561 |
2011 | MARK2 | A015-C-104 | Human | Colorectum | FAP | 1.67e-28 | -3.65e-01 | -0.1899 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051098 | Colorectum | AD | regulation of binding | 126/3918 | 363/18723 | 6.01e-10 | 4.88e-08 | 126 |
GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
GO:0022604 | Colorectum | AD | regulation of cell morphogenesis | 109/3918 | 309/18723 | 3.08e-09 | 2.07e-07 | 109 |
GO:0007163 | Colorectum | AD | establishment or maintenance of cell polarity | 77/3918 | 218/18723 | 5.72e-07 | 2.08e-05 | 77 |
GO:1903008 | Colorectum | AD | organelle disassembly | 46/3918 | 114/18723 | 1.81e-06 | 5.48e-05 | 46 |
GO:0000422 | Colorectum | AD | autophagy of mitochondrion | 35/3918 | 81/18723 | 4.94e-06 | 1.29e-04 | 35 |
GO:0061726 | Colorectum | AD | mitochondrion disassembly | 35/3918 | 81/18723 | 4.94e-06 | 1.29e-04 | 35 |
GO:0043393 | Colorectum | AD | regulation of protein binding | 68/3918 | 196/18723 | 5.17e-06 | 1.34e-04 | 68 |
GO:0008360 | Colorectum | AD | regulation of cell shape | 56/3918 | 154/18723 | 7.01e-06 | 1.73e-04 | 56 |
GO:0016055 | Colorectum | AD | Wnt signaling pathway | 130/3918 | 444/18723 | 1.60e-05 | 3.37e-04 | 130 |
GO:0198738 | Colorectum | AD | cell-cell signaling by wnt | 130/3918 | 446/18723 | 2.02e-05 | 4.10e-04 | 130 |
GO:0046777 | Colorectum | AD | protein autophosphorylation | 74/3918 | 227/18723 | 2.48e-05 | 4.76e-04 | 74 |
GO:0010975 | Colorectum | AD | regulation of neuron projection development | 129/3918 | 445/18723 | 2.88e-05 | 5.37e-04 | 129 |
GO:0007409 | Colorectum | AD | axonogenesis | 122/3918 | 418/18723 | 3.36e-05 | 6.15e-04 | 122 |
GO:0030010 | Colorectum | AD | establishment of cell polarity | 50/3918 | 143/18723 | 6.90e-05 | 1.11e-03 | 50 |
GO:0031346 | Colorectum | AD | positive regulation of cell projection organization | 104/3918 | 353/18723 | 8.26e-05 | 1.30e-03 | 104 |
GO:0061564 | Colorectum | AD | axon development | 132/3918 | 467/18723 | 8.40e-05 | 1.31e-03 | 132 |
GO:0033674 | Colorectum | AD | positive regulation of kinase activity | 131/3918 | 467/18723 | 1.28e-04 | 1.85e-03 | 131 |
GO:0045197 | Colorectum | AD | establishment or maintenance of epithelial cell apical/basal polarity | 20/3918 | 44/18723 | 2.26e-04 | 2.94e-03 | 20 |
GO:0035088 | Colorectum | AD | establishment or maintenance of apical/basal cell polarity | 21/3918 | 49/18723 | 4.31e-04 | 4.82e-03 | 21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MARK2 | SNV | Missense_Mutation | novel | c.341A>C | p.Lys114Thr | p.K114T | Q7KZI7 | protein_coding | deleterious(0) | probably_damaging(0.926) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MARK2 | SNV | Missense_Mutation | novel | c.1023G>T | p.Glu341Asp | p.E341D | Q7KZI7 | protein_coding | tolerated(0.22) | benign(0.007) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MARK2 | SNV | Missense_Mutation | c.1670N>A | p.Arg557Gln | p.R557Q | Q7KZI7 | protein_coding | tolerated(0.14) | benign(0.028) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
MARK2 | SNV | Missense_Mutation | c.458N>A | p.Arg153Gln | p.R153Q | Q7KZI7 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AZ-6608-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
MARK2 | SNV | Missense_Mutation | c.1109N>A | p.Gly370Asp | p.G370D | Q7KZI7 | protein_coding | deleterious(0.04) | benign(0.001) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MARK2 | SNV | Missense_Mutation | c.1833N>T | p.Leu611Phe | p.L611F | Q7KZI7 | protein_coding | deleterious(0.02) | benign(0.096) | TCGA-CM-6167-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
MARK2 | SNV | Missense_Mutation | c.1163C>T | p.Ala388Val | p.A388V | Q7KZI7 | protein_coding | tolerated(0.43) | benign(0.003) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MARK2 | SNV | Missense_Mutation | c.1081N>A | p.Leu361Met | p.L361M | Q7KZI7 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MARK2 | SNV | Missense_Mutation | novel | c.813N>A | p.Phe271Leu | p.F271L | Q7KZI7 | protein_coding | deleterious(0) | possibly_damaging(0.575) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MARK2 | deletion | Frame_Shift_Del | c.367delN | p.Thr124ArgfsTer18 | p.T124Rfs*18 | Q7KZI7 | protein_coding | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2011 | MARK2 | KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | TOZASERTIB | TOZASERTIB | ||
2011 | MARK2 | KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | LINIFANIB | LINIFANIB | ||
2011 | MARK2 | KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | DOVITINIB | DOVITINIB | ||
2011 | MARK2 | KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | GSK-269962A | GSK-269962A | ||
2011 | MARK2 | KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | TYROSINE KINASE INHIBITORS | 15811957 | ||
2011 | MARK2 | KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | GNF-PF-2301 | CHEMBL578061 | ||
2011 | MARK2 | KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | KENPAULLONE | KENPAULLONE | ||
2011 | MARK2 | KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | CENISERTIB | CENISERTIB | ||
2011 | MARK2 | KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | ALSTERPAULLONE | ALSTERPAULLONE | ||
2011 | MARK2 | KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | AZD-1080 | AZD-1080 |
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