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Gene: MAP7 |
Gene summary for MAP7 |
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Gene information | Species | Human | Gene symbol | MAP7 | Gene ID | 9053 |
Gene name | microtubule associated protein 7 | |
Gene Alias | E-MAP-115 | |
Cytomap | 6q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q14244 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9053 | MAP7 | CCI_1 | Human | Cervix | CC | 8.69e-09 | 8.41e-01 | 0.528 |
9053 | MAP7 | CCI_2 | Human | Cervix | CC | 1.39e-06 | 8.50e-01 | 0.5249 |
9053 | MAP7 | CCI_3 | Human | Cervix | CC | 5.98e-09 | 7.39e-01 | 0.516 |
9053 | MAP7 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.74e-19 | -6.07e-01 | 0.0155 |
9053 | MAP7 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.99e-06 | -4.42e-01 | -0.1808 |
9053 | MAP7 | HTA11_2951_2000001011 | Human | Colorectum | AD | 6.10e-09 | -9.38e-01 | 0.0216 |
9053 | MAP7 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.19e-07 | 5.75e-01 | -0.1954 |
9053 | MAP7 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.50e-04 | 6.02e-01 | -0.2602 |
9053 | MAP7 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.61e-04 | -5.34e-01 | -0.2061 |
9053 | MAP7 | HTA11_5216_2000001011 | Human | Colorectum | SER | 7.98e-07 | -5.69e-01 | -0.1462 |
9053 | MAP7 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.96e-04 | -3.48e-01 | -0.0179 |
9053 | MAP7 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.71e-07 | -5.09e-01 | 0.0528 |
9053 | MAP7 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.02e-02 | -4.11e-01 | 0.0338 |
9053 | MAP7 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.53e-06 | -4.18e-01 | 0.0674 |
9053 | MAP7 | HTA11_7469_2000001011 | Human | Colorectum | AD | 2.76e-04 | -5.58e-01 | -0.0124 |
9053 | MAP7 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 7.74e-13 | 8.43e-01 | 0.3487 |
9053 | MAP7 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.65e-07 | 5.57e-01 | 0.281 |
9053 | MAP7 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.01e-09 | -6.78e-01 | 0.2585 |
9053 | MAP7 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.96e-17 | -5.93e-01 | 0.3005 |
9053 | MAP7 | F007 | Human | Colorectum | FAP | 3.14e-03 | -3.39e-01 | 0.1176 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00071639 | Cervix | CC | establishment or maintenance of cell polarity | 63/2311 | 218/18723 | 4.25e-11 | 8.76e-09 | 63 |
GO:007265910 | Cervix | CC | protein localization to plasma membrane | 73/2311 | 284/18723 | 4.95e-10 | 6.73e-08 | 73 |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
GO:0007163 | Colorectum | AD | establishment or maintenance of cell polarity | 77/3918 | 218/18723 | 5.72e-07 | 2.08e-05 | 77 |
GO:00726591 | Colorectum | SER | protein localization to plasma membrane | 92/2897 | 284/18723 | 6.36e-13 | 1.86e-10 | 92 |
GO:19907781 | Colorectum | SER | protein localization to cell periphery | 98/2897 | 333/18723 | 6.09e-11 | 9.57e-09 | 98 |
GO:00071631 | Colorectum | SER | establishment or maintenance of cell polarity | 60/2897 | 218/18723 | 3.45e-06 | 1.33e-04 | 60 |
GO:0006970 | Colorectum | SER | response to osmotic stress | 23/2897 | 84/18723 | 3.61e-03 | 3.03e-02 | 23 |
GO:00726592 | Colorectum | MSS | protein localization to plasma membrane | 113/3467 | 284/18723 | 3.23e-17 | 1.55e-14 | 113 |
GO:19907782 | Colorectum | MSS | protein localization to cell periphery | 120/3467 | 333/18723 | 2.02e-14 | 5.47e-12 | 120 |
GO:00071632 | Colorectum | MSS | establishment or maintenance of cell polarity | 72/3467 | 218/18723 | 1.90e-07 | 8.30e-06 | 72 |
GO:00726593 | Colorectum | MSI-H | protein localization to plasma membrane | 38/1319 | 284/18723 | 1.03e-04 | 3.18e-03 | 38 |
GO:19907783 | Colorectum | MSI-H | protein localization to cell periphery | 40/1319 | 333/18723 | 6.61e-04 | 1.27e-02 | 40 |
GO:00726594 | Colorectum | FAP | protein localization to plasma membrane | 95/2622 | 284/18723 | 4.86e-17 | 9.93e-14 | 95 |
GO:19907784 | Colorectum | FAP | protein localization to cell periphery | 100/2622 | 333/18723 | 2.19e-14 | 2.68e-11 | 100 |
GO:00071633 | Colorectum | FAP | establishment or maintenance of cell polarity | 64/2622 | 218/18723 | 2.83e-09 | 5.07e-07 | 64 |
GO:00069701 | Colorectum | FAP | response to osmotic stress | 25/2622 | 84/18723 | 1.43e-04 | 2.24e-03 | 25 |
GO:00726595 | Colorectum | CRC | protein localization to plasma membrane | 80/2078 | 284/18723 | 1.36e-15 | 4.07e-12 | 80 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAP7 | SNV | Missense_Mutation | c.893N>T | p.Ser298Leu | p.S298L | protein_coding | tolerated(0.18) | benign(0.006) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MAP7 | SNV | Missense_Mutation | novel | c.1234N>G | p.Lys412Glu | p.K412E | protein_coding | tolerated(0.15) | possibly_damaging(0.888) | TCGA-AG-4015-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MAP7 | SNV | Missense_Mutation | novel | c.1262N>C | p.Lys421Thr | p.K421T | protein_coding | tolerated(0.06) | benign(0.155) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MAP7 | SNV | Missense_Mutation | novel | c.692C>A | p.Ser231Tyr | p.S231Y | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MAP7 | deletion | Frame_Shift_Del | c.978delN | p.Glu327LysfsTer102 | p.E327Kfs*102 | protein_coding | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||||
MAP7 | insertion | Frame_Shift_Ins | novel | c.159_160dupTA | p.Lys54IlefsTer51 | p.K54Ifs*51 | protein_coding | TCGA-AG-3727-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |||
MAP7 | SNV | Missense_Mutation | novel | c.1534N>A | p.Leu512Ile | p.L512I | protein_coding | tolerated(0.59) | benign(0.063) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAP7 | SNV | Missense_Mutation | novel | c.589N>A | p.Ala197Thr | p.A197T | protein_coding | tolerated(0.64) | benign(0.279) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAP7 | SNV | Missense_Mutation | novel | c.2182T>G | p.Leu728Val | p.L728V | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAP7 | SNV | Missense_Mutation | c.2261N>T | p.Ala754Val | p.A754V | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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