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Gene: MAGEA4 |
Gene summary for MAGEA4 |
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Gene information | Species | Human | Gene symbol | MAGEA4 | Gene ID | 4103 |
Gene name | MAGE family member A4 | |
Gene Alias | CT1.4 | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A0A024RC12 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4103 | MAGEA4 | LZE2T | Human | Esophagus | ESCC | 2.05e-21 | 1.78e+00 | 0.082 |
4103 | MAGEA4 | LZE4T | Human | Esophagus | ESCC | 5.68e-07 | 3.08e-01 | 0.0811 |
4103 | MAGEA4 | P1T-E | Human | Esophagus | ESCC | 4.53e-14 | 1.00e+00 | 0.0875 |
4103 | MAGEA4 | P5T-E | Human | Esophagus | ESCC | 2.85e-73 | 1.44e+00 | 0.1327 |
4103 | MAGEA4 | P9T-E | Human | Esophagus | ESCC | 2.41e-06 | 2.34e-01 | 0.1131 |
4103 | MAGEA4 | P16T-E | Human | Esophagus | ESCC | 2.45e-83 | 1.58e+00 | 0.1153 |
4103 | MAGEA4 | P17T-E | Human | Esophagus | ESCC | 1.45e-12 | 5.97e-01 | 0.1278 |
4103 | MAGEA4 | P24T-E | Human | Esophagus | ESCC | 1.45e-46 | 1.15e+00 | 0.1287 |
4103 | MAGEA4 | P26T-E | Human | Esophagus | ESCC | 1.87e-154 | 3.30e+00 | 0.1276 |
4103 | MAGEA4 | P27T-E | Human | Esophagus | ESCC | 2.06e-59 | 1.17e+00 | 0.1055 |
4103 | MAGEA4 | P28T-E | Human | Esophagus | ESCC | 3.82e-72 | 1.42e+00 | 0.1149 |
4103 | MAGEA4 | P37T-E | Human | Esophagus | ESCC | 2.34e-86 | 2.57e+00 | 0.1371 |
4103 | MAGEA4 | P38T-E | Human | Esophagus | ESCC | 2.41e-07 | 3.32e-01 | 0.127 |
4103 | MAGEA4 | P44T-E | Human | Esophagus | ESCC | 6.29e-05 | 1.90e-01 | 0.1096 |
4103 | MAGEA4 | P47T-E | Human | Esophagus | ESCC | 9.62e-68 | 1.39e+00 | 0.1067 |
4103 | MAGEA4 | P48T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.05e-01 | 0.0959 |
4103 | MAGEA4 | P52T-E | Human | Esophagus | ESCC | 7.28e-26 | 1.26e+00 | 0.1555 |
4103 | MAGEA4 | P54T-E | Human | Esophagus | ESCC | 1.34e-09 | 2.74e-01 | 0.0975 |
4103 | MAGEA4 | P56T-E | Human | Esophagus | ESCC | 3.08e-28 | 2.31e+00 | 0.1613 |
4103 | MAGEA4 | P57T-E | Human | Esophagus | ESCC | 2.86e-20 | 9.54e-01 | 0.0926 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004578710 | Esophagus | ESCC | positive regulation of cell cycle | 196/8552 | 313/18723 | 9.27e-10 | 2.24e-08 | 196 |
GO:004578711 | Liver | HCC | positive regulation of cell cycle | 172/7958 | 313/18723 | 5.29e-06 | 6.58e-05 | 172 |
GO:00457879 | Oral cavity | OSCC | positive regulation of cell cycle | 173/7305 | 313/18723 | 3.28e-09 | 7.44e-08 | 173 |
GO:004578717 | Skin | cSCC | positive regulation of cell cycle | 120/4864 | 313/18723 | 8.95e-07 | 1.64e-05 | 120 |
GO:004578719 | Thyroid | ATC | positive regulation of cell cycle | 158/6293 | 313/18723 | 4.18e-10 | 1.14e-08 | 158 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAGEA4 | SNV | Missense_Mutation | c.163N>T | p.Pro55Ser | p.P55S | P43358 | protein_coding | tolerated(0.27) | benign(0.071) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MAGEA4 | SNV | Missense_Mutation | novel | c.408N>A | p.Met136Ile | p.M136I | P43358 | protein_coding | tolerated(0.09) | benign(0.08) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
MAGEA4 | SNV | Missense_Mutation | c.280N>A | p.Glu94Lys | p.E94K | P43358 | protein_coding | tolerated(0.29) | probably_damaging(0.999) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAGEA4 | SNV | Missense_Mutation | c.896N>A | p.Arg299His | p.R299H | P43358 | protein_coding | tolerated(0.1) | benign(0.001) | TCGA-B5-A11N-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MAGEA4 | SNV | Missense_Mutation | novel | c.818N>C | p.Leu273Pro | p.L273P | P43358 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
MAGEA4 | SNV | Missense_Mutation | novel | c.185C>A | p.Pro62His | p.P62H | P43358 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAGEA4 | SNV | Missense_Mutation | c.895C>T | p.Arg299Cys | p.R299C | P43358 | protein_coding | deleterious(0.02) | possibly_damaging(0.777) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MAGEA4 | SNV | Missense_Mutation | c.275A>T | p.Glu92Val | p.E92V | P43358 | protein_coding | deleterious(0.04) | probably_damaging(0.992) | TCGA-BS-A0TE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
MAGEA4 | SNV | Missense_Mutation | rs866165760 | c.616N>A | p.Val206Ile | p.V206I | P43358 | protein_coding | tolerated(1) | benign(0.082) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAGEA4 | SNV | Missense_Mutation | rs190319017 | c.803N>T | p.Ala268Val | p.A268V | P43358 | protein_coding | tolerated(0.27) | benign(0.101) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4103 | MAGEA4 | NA | CAR-T cells targeting MAGE-A4 |
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