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Gene: LRRC8B |
Gene summary for LRRC8B |
Gene summary. |
Gene information | Species | Human | Gene symbol | LRRC8B | Gene ID | 23507 |
Gene name | leucine rich repeat containing 8 VRAC subunit B | |
Gene Alias | TA-LRRP | |
Cytomap | 1p22.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q6P9F7 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23507 | LRRC8B | LZE4T | Human | Esophagus | ESCC | 1.06e-04 | 9.98e-02 | 0.0811 |
23507 | LRRC8B | LZE22T | Human | Esophagus | ESCC | 2.26e-02 | 1.50e-01 | 0.068 |
23507 | LRRC8B | LZE24T | Human | Esophagus | ESCC | 3.69e-05 | 1.33e-01 | 0.0596 |
23507 | LRRC8B | P2T-E | Human | Esophagus | ESCC | 8.02e-12 | 1.62e-01 | 0.1177 |
23507 | LRRC8B | P4T-E | Human | Esophagus | ESCC | 5.49e-09 | 1.37e-01 | 0.1323 |
23507 | LRRC8B | P5T-E | Human | Esophagus | ESCC | 1.47e-06 | 1.31e-01 | 0.1327 |
23507 | LRRC8B | P8T-E | Human | Esophagus | ESCC | 1.48e-05 | 6.48e-02 | 0.0889 |
23507 | LRRC8B | P9T-E | Human | Esophagus | ESCC | 4.29e-03 | 1.23e-01 | 0.1131 |
23507 | LRRC8B | P10T-E | Human | Esophagus | ESCC | 7.40e-06 | 9.31e-02 | 0.116 |
23507 | LRRC8B | P11T-E | Human | Esophagus | ESCC | 6.57e-03 | 7.42e-02 | 0.1426 |
23507 | LRRC8B | P12T-E | Human | Esophagus | ESCC | 1.02e-65 | 1.29e+00 | 0.1122 |
23507 | LRRC8B | P15T-E | Human | Esophagus | ESCC | 1.63e-11 | 2.22e-01 | 0.1149 |
23507 | LRRC8B | P16T-E | Human | Esophagus | ESCC | 2.83e-05 | 1.35e-02 | 0.1153 |
23507 | LRRC8B | P20T-E | Human | Esophagus | ESCC | 1.71e-07 | 1.30e-01 | 0.1124 |
23507 | LRRC8B | P22T-E | Human | Esophagus | ESCC | 1.97e-02 | -1.84e-02 | 0.1236 |
23507 | LRRC8B | P23T-E | Human | Esophagus | ESCC | 1.54e-15 | 2.83e-01 | 0.108 |
23507 | LRRC8B | P24T-E | Human | Esophagus | ESCC | 1.62e-04 | 1.95e-02 | 0.1287 |
23507 | LRRC8B | P26T-E | Human | Esophagus | ESCC | 5.87e-12 | 3.10e-01 | 0.1276 |
23507 | LRRC8B | P27T-E | Human | Esophagus | ESCC | 2.82e-06 | 1.13e-01 | 0.1055 |
23507 | LRRC8B | P28T-E | Human | Esophagus | ESCC | 3.15e-11 | 1.87e-01 | 0.1149 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRRC8B | SNV | Missense_Mutation | novel | c.561N>T | p.Lys187Asn | p.K187N | protein_coding | tolerated(0.55) | benign(0.007) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LRRC8B | SNV | Missense_Mutation | rs144661004 | c.1289N>G | p.Asn430Ser | p.N430S | protein_coding | tolerated(1) | benign(0) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LRRC8B | SNV | Missense_Mutation | rs181978158 | c.202N>A | p.Val68Met | p.V68M | protein_coding | tolerated(0.19) | benign(0.382) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
LRRC8B | SNV | Missense_Mutation | novel | c.1215N>T | p.Trp405Cys | p.W405C | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AX-A1C5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | SD | |
LRRC8B | SNV | Missense_Mutation | novel | c.1522C>T | p.His508Tyr | p.H508Y | protein_coding | tolerated(1) | benign(0) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | |
LRRC8B | SNV | Missense_Mutation | novel | c.1961C>T | p.Ala654Val | p.A654V | protein_coding | tolerated(0.23) | benign(0.001) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | |
LRRC8B | SNV | Missense_Mutation | rs755825664 | c.275G>A | p.Arg92Gln | p.R92Q | protein_coding | tolerated(0.18) | benign(0.04) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
LRRC8B | SNV | Missense_Mutation | c.1796N>A | p.Arg599His | p.R599H | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-B5-A0K9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
LRRC8B | SNV | Missense_Mutation | c.1448C>T | p.Ala483Val | p.A483V | protein_coding | tolerated(0.59) | benign(0.017) | TCGA-B5-A11Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
LRRC8B | SNV | Missense_Mutation | rs755825664 | c.275N>A | p.Arg92Gln | p.R92Q | protein_coding | tolerated(0.18) | benign(0.04) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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