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Gene: LAD1 |
Gene summary for LAD1 |
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Gene information | Species | Human | Gene symbol | LAD1 | Gene ID | 3898 |
Gene name | ladinin 1 | |
Gene Alias | LadA | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | O00515 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3898 | LAD1 | N_HPV_2 | Human | Cervix | N_HPV | 6.56e-03 | 2.43e-01 | -0.0131 |
3898 | LAD1 | Tumor | Human | Cervix | CC | 5.38e-34 | 6.83e-01 | 0.1241 |
3898 | LAD1 | sample3 | Human | Cervix | CC | 1.48e-36 | 5.42e-01 | 0.1387 |
3898 | LAD1 | L1 | Human | Cervix | CC | 4.70e-03 | 3.82e-01 | 0.0802 |
3898 | LAD1 | T3 | Human | Cervix | CC | 1.21e-32 | 5.78e-01 | 0.1389 |
3898 | LAD1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.44e-16 | 5.19e-01 | 0.0155 |
3898 | LAD1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.23e-31 | 1.33e+00 | -0.1808 |
3898 | LAD1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.61e-02 | 4.72e-01 | 0.0216 |
3898 | LAD1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.20e-31 | 1.22e+00 | -0.0811 |
3898 | LAD1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.99e-17 | 8.02e-01 | -0.1088 |
3898 | LAD1 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.27e-40 | 9.86e-01 | -0.1954 |
3898 | LAD1 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.97e-09 | 1.59e+00 | -0.2602 |
3898 | LAD1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.35e-08 | 1.10e+00 | -0.2196 |
3898 | LAD1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.89e-28 | 1.13e+00 | -0.1207 |
3898 | LAD1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.06e-19 | 1.08e+00 | -0.1526 |
3898 | LAD1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.14e-33 | 9.56e-01 | -0.1464 |
3898 | LAD1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.82e-23 | 6.47e-01 | -0.1001 |
3898 | LAD1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.88e-42 | 1.46e+00 | -0.059 |
3898 | LAD1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.76e-08 | 9.96e-01 | -0.1706 |
3898 | LAD1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.85e-10 | 9.07e-01 | -0.2061 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006753110 | Esophagus | ESCC | nucleoside phosphate metabolic process | 288/8552 | 497/18723 | 1.80e-08 | 3.50e-07 | 288 |
GO:0009117111 | Esophagus | ESCC | nucleotide metabolic process | 282/8552 | 489/18723 | 4.70e-08 | 8.50e-07 | 282 |
GO:000916516 | Esophagus | ESCC | nucleotide biosynthetic process | 150/8552 | 254/18723 | 1.12e-05 | 1.06e-04 | 150 |
GO:190129316 | Esophagus | ESCC | nucleoside phosphate biosynthetic process | 151/8552 | 256/18723 | 1.15e-05 | 1.08e-04 | 151 |
GO:00067671 | Esophagus | ESCC | water-soluble vitamin metabolic process | 41/8552 | 59/18723 | 1.84e-04 | 1.17e-03 | 41 |
GO:00067661 | Esophagus | ESCC | vitamin metabolic process | 67/8552 | 106/18723 | 2.03e-04 | 1.28e-03 | 67 |
GO:000911722 | Liver | HCC | nucleotide metabolic process | 300/7958 | 489/18723 | 1.61e-17 | 1.71e-15 | 300 |
GO:000675322 | Liver | HCC | nucleoside phosphate metabolic process | 304/7958 | 497/18723 | 1.78e-17 | 1.85e-15 | 304 |
GO:000916512 | Liver | HCC | nucleotide biosynthetic process | 150/7958 | 254/18723 | 6.79e-08 | 1.40e-06 | 150 |
GO:190129312 | Liver | HCC | nucleoside phosphate biosynthetic process | 151/7958 | 256/18723 | 6.84e-08 | 1.41e-06 | 151 |
GO:0006767 | Liver | HCC | water-soluble vitamin metabolic process | 39/7958 | 59/18723 | 2.14e-04 | 1.63e-03 | 39 |
GO:0006766 | Liver | HCC | vitamin metabolic process | 57/7958 | 106/18723 | 1.25e-02 | 4.53e-02 | 57 |
GO:000675318 | Oral cavity | OSCC | nucleoside phosphate metabolic process | 247/7305 | 497/18723 | 6.28e-07 | 8.96e-06 | 247 |
GO:000911719 | Oral cavity | OSCC | nucleotide metabolic process | 243/7305 | 489/18723 | 7.80e-07 | 1.09e-05 | 243 |
GO:19012938 | Oral cavity | OSCC | nucleoside phosphate biosynthetic process | 125/7305 | 256/18723 | 8.32e-04 | 4.41e-03 | 125 |
GO:00091658 | Oral cavity | OSCC | nucleotide biosynthetic process | 124/7305 | 254/18723 | 8.79e-04 | 4.63e-03 | 124 |
GO:000675319 | Oral cavity | LP | nucleoside phosphate metabolic process | 161/4623 | 497/18723 | 5.31e-05 | 7.39e-04 | 161 |
GO:0009117110 | Oral cavity | LP | nucleotide metabolic process | 158/4623 | 489/18723 | 7.17e-05 | 9.49e-04 | 158 |
GO:190129315 | Oral cavity | LP | nucleoside phosphate biosynthetic process | 84/4623 | 256/18723 | 1.98e-03 | 1.47e-02 | 84 |
GO:000916515 | Oral cavity | LP | nucleotide biosynthetic process | 83/4623 | 254/18723 | 2.38e-03 | 1.71e-02 | 83 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LAD1 | SNV | Missense_Mutation | c.1250N>T | p.Arg417Ile | p.R417I | O00515 | protein_coding | deleterious(0) | possibly_damaging(0.664) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LAD1 | SNV | Missense_Mutation | rs750609613 | c.889G>A | p.Ala297Thr | p.A297T | O00515 | protein_coding | tolerated(0.11) | benign(0.011) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LAD1 | SNV | Missense_Mutation | rs754957644 | c.104N>A | p.Arg35His | p.R35H | O00515 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LAD1 | insertion | In_Frame_Ins | novel | c.1146_1147insCCCAAGAAA | p.Pro380_Lys382dup | p.P380_K382dup | O00515 | protein_coding | TCGA-EY-A1GO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | ||
LAD1 | SNV | Missense_Mutation | novel | c.604N>G | p.Ile202Val | p.I202V | O00515 | protein_coding | tolerated(0.92) | benign(0) | TCGA-2Y-A9GZ-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Targeted Molecular therapy | sorafenib | PD |
LAD1 | SNV | Missense_Mutation | novel | c.935N>A | p.Ala312Asp | p.A312D | O00515 | protein_coding | tolerated(0.16) | benign(0.021) | TCGA-CC-A8HV-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Targeted Molecular therapy | sorafenib | PD |
LAD1 | SNV | Missense_Mutation | c.893N>A | p.Ser298Tyr | p.S298Y | O00515 | protein_coding | deleterious(0.04) | benign(0.033) | TCGA-35-5375-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
LAD1 | SNV | Missense_Mutation | rs765601402 | c.133N>T | p.Ala45Ser | p.A45S | O00515 | protein_coding | tolerated(0.46) | benign(0.02) | TCGA-35-5375-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
LAD1 | SNV | Missense_Mutation | c.716N>T | p.Ser239Phe | p.S239F | O00515 | protein_coding | tolerated(0.45) | benign(0.316) | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LAD1 | SNV | Missense_Mutation | rs552773617 | c.1129N>T | p.Arg377Trp | p.R377W | O00515 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-55-7227-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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