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Gene: KLHL5 |
Gene summary for KLHL5 |
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Gene information | Species | Human | Gene symbol | KLHL5 | Gene ID | 51088 |
Gene name | kelch like family member 5 | |
Gene Alias | KLHL5 | |
Cytomap | 4p14 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q7Z6D5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51088 | KLHL5 | LZE24T | Human | Esophagus | ESCC | 2.73e-07 | 3.02e-01 | 0.0596 |
51088 | KLHL5 | P2T-E | Human | Esophagus | ESCC | 1.19e-10 | 2.00e-01 | 0.1177 |
51088 | KLHL5 | P4T-E | Human | Esophagus | ESCC | 9.46e-14 | 1.56e-01 | 0.1323 |
51088 | KLHL5 | P5T-E | Human | Esophagus | ESCC | 9.32e-05 | 4.02e-02 | 0.1327 |
51088 | KLHL5 | P8T-E | Human | Esophagus | ESCC | 5.96e-17 | 3.67e-01 | 0.0889 |
51088 | KLHL5 | P9T-E | Human | Esophagus | ESCC | 7.05e-08 | 1.29e-01 | 0.1131 |
51088 | KLHL5 | P11T-E | Human | Esophagus | ESCC | 2.24e-06 | 3.55e-01 | 0.1426 |
51088 | KLHL5 | P12T-E | Human | Esophagus | ESCC | 6.60e-17 | 3.33e-01 | 0.1122 |
51088 | KLHL5 | P15T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.51e-01 | 0.1149 |
51088 | KLHL5 | P16T-E | Human | Esophagus | ESCC | 7.90e-05 | 2.75e-02 | 0.1153 |
51088 | KLHL5 | P21T-E | Human | Esophagus | ESCC | 9.60e-03 | 5.67e-02 | 0.1617 |
51088 | KLHL5 | P22T-E | Human | Esophagus | ESCC | 1.36e-04 | 6.42e-02 | 0.1236 |
51088 | KLHL5 | P23T-E | Human | Esophagus | ESCC | 1.76e-06 | 2.90e-01 | 0.108 |
51088 | KLHL5 | P24T-E | Human | Esophagus | ESCC | 9.83e-03 | 5.58e-02 | 0.1287 |
51088 | KLHL5 | P26T-E | Human | Esophagus | ESCC | 5.11e-11 | 2.25e-01 | 0.1276 |
51088 | KLHL5 | P27T-E | Human | Esophagus | ESCC | 7.13e-05 | 1.38e-01 | 0.1055 |
51088 | KLHL5 | P30T-E | Human | Esophagus | ESCC | 3.42e-03 | 1.42e-01 | 0.137 |
51088 | KLHL5 | P31T-E | Human | Esophagus | ESCC | 2.66e-11 | 2.35e-01 | 0.1251 |
51088 | KLHL5 | P32T-E | Human | Esophagus | ESCC | 7.35e-10 | 2.54e-01 | 0.1666 |
51088 | KLHL5 | P36T-E | Human | Esophagus | ESCC | 1.84e-04 | 1.71e-01 | 0.1187 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLHL5 | SNV | Missense_Mutation | c.1814N>C | p.Val605Ala | p.V605A | Q96PQ7 | protein_coding | tolerated(0.53) | benign(0.015) | TCGA-CM-5864-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KLHL5 | SNV | Missense_Mutation | novel | c.713T>C | p.Leu238Pro | p.L238P | Q96PQ7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D5-5537-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
KLHL5 | SNV | Missense_Mutation | c.603T>G | p.Asn201Lys | p.N201K | Q96PQ7 | protein_coding | tolerated(0.31) | benign(0.036) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KLHL5 | SNV | Missense_Mutation | c.118G>A | p.Asp40Asn | p.D40N | Q96PQ7 | protein_coding | tolerated_low_confidence(0.46) | benign(0) | TCGA-G4-6303-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD | |
KLHL5 | SNV | Missense_Mutation | c.479G>A | p.Gly160Asp | p.G160D | Q96PQ7 | protein_coding | tolerated_low_confidence(0.4) | benign(0.015) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
KLHL5 | SNV | Missense_Mutation | c.621T>A | p.Phe207Leu | p.F207L | Q96PQ7 | protein_coding | tolerated(1) | benign(0.028) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
KLHL5 | SNV | Missense_Mutation | rs201110544 | c.344N>A | p.Arg115Gln | p.R115Q | Q96PQ7 | protein_coding | tolerated_low_confidence(0.77) | benign(0) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KLHL5 | SNV | Missense_Mutation | novel | c.1211N>C | p.Lys404Thr | p.K404T | Q96PQ7 | protein_coding | tolerated(0.58) | benign(0.038) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KLHL5 | SNV | Missense_Mutation | c.1433N>T | p.Thr478Ile | p.T478I | Q96PQ7 | protein_coding | tolerated(0.37) | possibly_damaging(0.516) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |
KLHL5 | SNV | Missense_Mutation | rs767326522 | c.976C>T | p.Arg326Cys | p.R326C | Q96PQ7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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