![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: KLHDC7B |
Gene summary for KLHDC7B |
![]() |
Gene information | Species | Human | Gene symbol | KLHDC7B | Gene ID | 113730 |
Gene name | kelch domain containing 7B | |
Gene Alias | KLHDC7B | |
Cytomap | 22q13.33 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q96G42 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
113730 | KLHDC7B | Tumor | Human | Cervix | CC | 2.37e-52 | 1.03e+00 | 0.1241 |
113730 | KLHDC7B | sample1 | Human | Cervix | CC | 6.72e-05 | 3.69e-01 | 0.0959 |
113730 | KLHDC7B | sample3 | Human | Cervix | CC | 1.73e-64 | 1.10e+00 | 0.1387 |
113730 | KLHDC7B | T1 | Human | Cervix | CC | 2.46e-07 | 3.18e-01 | 0.0918 |
113730 | KLHDC7B | T3 | Human | Cervix | CC | 2.38e-63 | 1.09e+00 | 0.1389 |
113730 | KLHDC7B | P2T-E | Human | Esophagus | ESCC | 2.28e-35 | 7.07e-01 | 0.1177 |
113730 | KLHDC7B | P31T-E | Human | Esophagus | ESCC | 5.30e-21 | 5.33e-01 | 0.1251 |
113730 | KLHDC7B | P36T-E | Human | Esophagus | ESCC | 7.91e-07 | 2.27e-01 | 0.1187 |
113730 | KLHDC7B | P130T-E | Human | Esophagus | ESCC | 2.93e-15 | 4.36e-01 | 0.1676 |
113730 | KLHDC7B | C46 | Human | Oral cavity | OSCC | 2.12e-31 | 7.12e-01 | 0.1673 |
113730 | KLHDC7B | LN22 | Human | Oral cavity | OSCC | 9.22e-13 | 9.37e-01 | 0.1733 |
113730 | KLHDC7B | LN46 | Human | Oral cavity | OSCC | 2.85e-13 | 4.88e-01 | 0.1666 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLHDC7B | SNV | Missense_Mutation | novel | c.1112N>T | p.Cys371Phe | p.C371F | Q96G42 | protein_coding | deleterious(0.01) | possibly_damaging(0.82) | TCGA-77-8154-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KLHDC7B | SNV | Missense_Mutation | rs773683142 | c.1450N>T | p.Arg484Cys | p.R484C | Q96G42 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-98-8020-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
KLHDC7B | SNV | Missense_Mutation | c.983G>T | p.Arg328Leu | p.R328L | Q96G42 | protein_coding | tolerated(0.24) | benign(0.07) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD | |
KLHDC7B | insertion | Frame_Shift_Ins | novel | c.1472_1473insG | p.Phe494LeufsTer94 | p.F494Lfs*94 | Q96G42 | protein_coding | TCGA-QK-A6VB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
KLHDC7B | SNV | Missense_Mutation | rs758694348 | c.1385N>A | p.Arg462His | p.R462H | Q96G42 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-BR-4368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
KLHDC7B | SNV | Missense_Mutation | rs371425484 | c.1294N>A | p.Ala432Thr | p.A432T | Q96G42 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
KLHDC7B | SNV | Missense_Mutation | rs758075611 | c.1504C>T | p.Arg502Trp | p.R502W | Q96G42 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KLHDC7B | SNV | Missense_Mutation | rs752754069 | c.1490G>A | p.Arg497His | p.R497H | Q96G42 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD |
KLHDC7B | SNV | Missense_Mutation | rs144157815 | c.1306G>A | p.Ala436Thr | p.A436T | Q96G42 | protein_coding | tolerated(0.2) | benign(0.125) | TCGA-R5-A7ZI-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
KLHDC7B | SNV | Missense_Mutation | rs750273973 | c.1528C>T | p.Arg510Cys | p.R510C | Q96G42 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |