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Gene: KLB |
Gene summary for KLB |
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Gene information | Species | Human | Gene symbol | KLB | Gene ID | 152831 |
Gene name | klotho beta | |
Gene Alias | BKL | |
Cytomap | 4p14 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | B4DYH5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
152831 | KLB | S43 | Human | Liver | Cirrhotic | 4.06e-02 | -6.65e-02 | -0.0187 |
152831 | KLB | HCC1_Meng | Human | Liver | HCC | 4.26e-48 | 1.30e-01 | 0.0246 |
152831 | KLB | HCC1 | Human | Liver | HCC | 3.94e-22 | 4.25e+00 | 0.5336 |
152831 | KLB | HCC2 | Human | Liver | HCC | 1.73e-22 | 3.42e+00 | 0.5341 |
152831 | KLB | HCC5 | Human | Liver | HCC | 7.53e-06 | 1.01e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0471414 | Liver | Cirrhotic | Thermogenesis | 121/2530 | 232/8465 | 5.70e-13 | 1.36e-11 | 8.36e-12 | 121 |
hsa0471415 | Liver | Cirrhotic | Thermogenesis | 121/2530 | 232/8465 | 5.70e-13 | 1.36e-11 | 8.36e-12 | 121 |
hsa0471422 | Liver | HCC | Thermogenesis | 170/4020 | 232/8465 | 5.36e-16 | 2.25e-14 | 1.25e-14 | 170 |
hsa0471432 | Liver | HCC | Thermogenesis | 170/4020 | 232/8465 | 5.36e-16 | 2.25e-14 | 1.25e-14 | 170 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLB | SNV | Missense_Mutation | novel | c.1720N>A | p.Ala574Thr | p.A574T | Q86Z14 | protein_coding | tolerated(0.23) | possibly_damaging(0.491) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KLB | SNV | Missense_Mutation | rs201377023 | c.929N>T | p.Ser310Leu | p.S310L | Q86Z14 | protein_coding | tolerated(0.61) | benign(0.102) | TCGA-CK-6747-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KLB | SNV | Missense_Mutation | novel | c.1619N>T | p.Ala540Val | p.A540V | Q86Z14 | protein_coding | tolerated(0.76) | benign(0.007) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KLB | SNV | Missense_Mutation | c.2818N>T | p.Pro940Ser | p.P940S | Q86Z14 | protein_coding | deleterious(0.03) | benign(0.145) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KLB | SNV | Missense_Mutation | c.737N>T | p.Ala246Val | p.A246V | Q86Z14 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KLB | SNV | Missense_Mutation | novel | c.787N>G | p.Leu263Val | p.L263V | Q86Z14 | protein_coding | tolerated(0.35) | benign(0.003) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KLB | SNV | Missense_Mutation | c.2917A>G | p.Ser973Gly | p.S973G | Q86Z14 | protein_coding | tolerated(0.39) | benign(0) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
KLB | SNV | Missense_Mutation | novel | c.149T>G | p.Val50Gly | p.V50G | Q86Z14 | protein_coding | deleterious(0) | benign(0.081) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KLB | SNV | Missense_Mutation | novel | c.2830T>C | p.Phe944Leu | p.F944L | Q86Z14 | protein_coding | tolerated(0.95) | benign(0.182) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KLB | SNV | Missense_Mutation | novel | c.583C>T | p.His195Tyr | p.H195Y | Q86Z14 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
152831 | KLB | ENZYME | NGM313 | |||
152831 | KLB | ENZYME | ethanol | ALCOHOL |
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